FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379470875> ?p ?o ?g. }

• W4379470875 abstract "Background Additional antimicrobial resistance to extended-spectrum β-lactamase (ESBL)-producing E. coli exhausts treatment options. We investigated allele distribution and resistance to ciprofloxacin and gentamicin among ESBL-producing E. coli isolates from the urine, stool, animals, and environments of presumptive urinary tract infection (UTI) patients, in order to gain a crucial insight toward devising prevention and control measures and treatment guidelines. Methods Archived ESBL-producing E. coli isolates from the urine, stool, animals, and surrounding environments of presumptive UTI patients were retrieved. Antimicrobial susceptibility profiles for ciprofloxacin and gentamicin were done followed by multiplex Polymerase chain reaction (PCR) for bla CTX-M , bla TEM , and bla SHV , to determine ESBL allele distribution. Data were analyzed using STATA version 17. Results A total of 472 confirmed ESBL-producing E. coli isolates from Mwanza 243 (51.5%), Kilimanjaro 143 (30.3%), and Mbeya 86 (18.2%) were analyzed. Of these, 75 (15.9%) were from urine, 199 (42.2%) from stool, 58 (12.3%) from rectal/cloaca swabs of animals, and 140 (29.7%) from surrounding environments. Out of the 472 ESBL-producing E. coli , 98.9% (467) had at least one ESBL allele. The most frequent allele was bla CTX-M , which was detected in 88.1% (416/472) of isolates, followed by the bla TEM allele, which was detected in 51.5% (243/472) of isolates. A total of 40.7% (192/472) of isolates harbored dual bla CTX-M + bla TEM alleles and only 0.2% (1/472) of isolates had dual bla CTX-M + bla SHV alleles, whereas 2.3% (11/472) of isolates had a combination of all three alleles ( bla CTX-M + bla TEM + bla SHV ). None of the isolates harbored a combination of bla TEM + bla SHV only. Resistance to ciprofloxacin and gentamicin was observed in 70.8% (334/472) and 46.0% (217/472) of isolates, respectively. There was a significant difference in the distribution of resistance to ciprofloxacin as well as gentamicin among ESBL-producing E. coli isolated from various sources ( p -value &lt; 0.001 and 0.002, respectively). Conclusion Almost all ESBL-producing E. coli isolates carry bla CTX-M , bla TEM , and bla SHV either alone or in combination, with the most common allele being bla CTX-M. The resistance to ciprofloxacin and gentamicin, which are frontline antibiotics for UTIs among ESBL-producing E. coli , is high. This implies the need to continually revise the local guidelines used for optimal empirical therapy for UTIs, and for continual research and surveillance using one health approach." @default.
• W4379470875 created "2023-06-07" @default.
• W4379470875 creator A5007241517 @default.
• W4379470875 creator A5011413855 @default.
• W4379470875 creator A5012144073 @default.
• W4379470875 creator A5029912656 @default.
• W4379470875 creator A5031864939 @default.
• W4379470875 creator A5068133346 @default.
• W4379470875 creator A5082060037 @default.
• W4379470875 creator A5086760804 @default.
• W4379470875 date "2023-06-05" @default.
• W4379470875 modified "2023-10-07" @default.
• W4379470875 title "Allele distribution and phenotypic resistance to ciprofloxacin and gentamicin among extended-spectrum β-lactamase-producing Escherichia coli isolated from the urine, stool, animals, and environments of patients with presumptive urinary tract infection in Tanzania" @default.
• W4379470875 cites W1531505040 @default.
• W4379470875 cites W1810935850 @default.
• W4379470875 cites W1876965404 @default.
• W4379470875 cites W1963482451 @default.
• W4379470875 cites W1972323571 @default.
• W4379470875 cites W1989122238 @default.
• W4379470875 cites W1992502459 @default.
• W4379470875 cites W2001414833 @default.
• W4379470875 cites W2002921064 @default.
• W4379470875 cites W2006393391 @default.
• W4379470875 cites W2042166722 @default.
• W4379470875 cites W2056676458 @default.
• W4379470875 cites W2057690968 @default.
• W4379470875 cites W2069215373 @default.
• W4379470875 cites W2086228598 @default.
• W4379470875 cites W2087341525 @default.
• W4379470875 cites W2090751630 @default.
• W4379470875 cites W2098716491 @default.
• W4379470875 cites W2102722490 @default.
• W4379470875 cites W2107117556 @default.
• W4379470875 cites W2108510217 @default.
• W4379470875 cites W2131946678 @default.
• W4379470875 cites W2136566983 @default.
• W4379470875 cites W2144148663 @default.
• W4379470875 cites W2144786496 @default.
• W4379470875 cites W2163186898 @default.
• W4379470875 cites W2293864176 @default.
• W4379470875 cites W2333298660 @default.
• W4379470875 cites W2344983691 @default.
• W4379470875 cites W2414688552 @default.
• W4379470875 cites W2580209934 @default.
• W4379470875 cites W2606689659 @default.
• W4379470875 cites W2755195032 @default.
• W4379470875 cites W2781917920 @default.
• W4379470875 cites W2810241670 @default.
• W4379470875 cites W2945185591 @default.
• W4379470875 cites W2983741769 @default.
• W4379470875 cites W3126609626 @default.
• W4379470875 cites W3135024082 @default.
• W4379470875 cites W3155988106 @default.
• W4379470875 cites W3156857129 @default.
• W4379470875 cites W3165995686 @default.
• W4379470875 cites W3169601472 @default.
• W4379470875 cites W3181972065 @default.
• W4379470875 cites W4206677002 @default.
• W4379470875 cites W4220821485 @default.
• W4379470875 cites W4220954776 @default.
• W4379470875 cites W4255896460 @default.
• W4379470875 doi "https://doi.org/10.3389/frabi.2023.1164016" @default.
• W4379470875 hasPublicationYear "2023" @default.
• W4379470875 type Work @default.
• W4379470875 citedByCount "0" @default.
• W4379470875 crossrefType "journal-article" @default.
• W4379470875 hasAuthorship W4379470875A5007241517 @default.
• W4379470875 hasAuthorship W4379470875A5011413855 @default.
• W4379470875 hasAuthorship W4379470875A5012144073 @default.
• W4379470875 hasAuthorship W4379470875A5029912656 @default.
• W4379470875 hasAuthorship W4379470875A5031864939 @default.
• W4379470875 hasAuthorship W4379470875A5068133346 @default.
• W4379470875 hasAuthorship W4379470875A5082060037 @default.
• W4379470875 hasAuthorship W4379470875A5086760804 @default.
• W4379470875 hasBestOaLocation W43794708751 @default.
• W4379470875 hasConcept C104317684 @default.
• W4379470875 hasConcept C114851261 @default.
• W4379470875 hasConcept C134018914 @default.
• W4379470875 hasConcept C180754005 @default.
• W4379470875 hasConcept C2775832221 @default.
• W4379470875 hasConcept C2778512257 @default.
• W4379470875 hasConcept C2780026642 @default.
• W4379470875 hasConcept C2781288988 @default.
• W4379470875 hasConcept C49105822 @default.
• W4379470875 hasConcept C501593827 @default.
• W4379470875 hasConcept C54355233 @default.
• W4379470875 hasConcept C547475151 @default.
• W4379470875 hasConcept C55493867 @default.
• W4379470875 hasConcept C77411442 @default.
• W4379470875 hasConcept C86803240 @default.
• W4379470875 hasConcept C89423630 @default.
• W4379470875 hasConcept C90583042 @default.
• W4379470875 hasConcept C94665300 @default.
• W4379470875 hasConceptScore W4379470875C104317684 @default.
• W4379470875 hasConceptScore W4379470875C114851261 @default.
• W4379470875 hasConceptScore W4379470875C134018914 @default.
• W4379470875 hasConceptScore W4379470875C180754005 @default.
• W4379470875 hasConceptScore W4379470875C2775832221 @default.
• W4379470875 hasConceptScore W4379470875C2778512257 @default.
• W4379470875 hasConceptScore W4379470875C2780026642 @default.

• next