Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379507980> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4379507980 abstract "Human aldose reductase, a target for the development of inhibitors for preventing diabetic complications, displays a transient specificity pocket which opens upon binding with specific, potent inhibitors. We investigated the opening mechanism of this pocket by mutating leucine residues involved in the gate keeping mechanism to alanine. Two isostructural inhibitors distinguished only by a single nitro to carboxy group replacement, have a 1000-fold difference in their binding affinity to the wild type. This difference is reduced to 10-fold in the mutated variants as the nitro derivative loses in affinity but conserves binding to the open transient pocket. The affinity of the carboxylate analog is minimally altered but the analog binding preference changes from the closed to open state of the transient pocket. Differences in the solvation properties of ligands and the transient pocket as well as changes from induced fit to conformational selections provide an explanation for the altered behavior of the ligands with respect to their binding to the different variants." @default.
- W4379507980 created "2023-06-07" @default.
- W4379507980 creator A5005420915 @default.
- W4379507980 creator A5085961742 @default.
- W4379507980 creator A5087835830 @default.
- W4379507980 creator A5089445591 @default.
- W4379507980 creator A5092095916 @default.
- W4379507980 date "2023-07-05" @default.
- W4379507980 modified "2023-09-25" @default.
- W4379507980 title "Mutational Studies of Aldose Reductase to Trace a Transient Pocket Opening and to Explain Ligand Affinity Cliffs" @default.
- W4379507980 cites W1661379300 @default.
- W4379507980 cites W1986191025 @default.
- W4379507980 cites W2024726841 @default.
- W4379507980 cites W2025701628 @default.
- W4379507980 cites W2028035578 @default.
- W4379507980 cites W2028556267 @default.
- W4379507980 cites W2028644941 @default.
- W4379507980 cites W2035992044 @default.
- W4379507980 cites W2036620149 @default.
- W4379507980 cites W2044437167 @default.
- W4379507980 cites W2047477946 @default.
- W4379507980 cites W2066746672 @default.
- W4379507980 cites W2080847413 @default.
- W4379507980 cites W2088204921 @default.
- W4379507980 cites W2100931593 @default.
- W4379507980 cites W2124026197 @default.
- W4379507980 cites W2154714625 @default.
- W4379507980 cites W2159749487 @default.
- W4379507980 cites W2163341755 @default.
- W4379507980 cites W2180229411 @default.
- W4379507980 cites W2313705563 @default.
- W4379507980 cites W2404280981 @default.
- W4379507980 cites W2471981404 @default.
- W4379507980 cites W2596390089 @default.
- W4379507980 cites W2769496043 @default.
- W4379507980 cites W2915042619 @default.
- W4379507980 cites W4248872320 @default.
- W4379507980 doi "https://doi.org/10.1002/cmdc.202300222" @default.
- W4379507980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37278327" @default.
- W4379507980 hasPublicationYear "2023" @default.
- W4379507980 type Work @default.
- W4379507980 citedByCount "0" @default.
- W4379507980 crossrefType "journal-article" @default.
- W4379507980 hasAuthorship W4379507980A5005420915 @default.
- W4379507980 hasAuthorship W4379507980A5085961742 @default.
- W4379507980 hasAuthorship W4379507980A5087835830 @default.
- W4379507980 hasAuthorship W4379507980A5089445591 @default.
- W4379507980 hasAuthorship W4379507980A5092095916 @default.
- W4379507980 hasBestOaLocation W43795079801 @default.
- W4379507980 hasConcept C107824862 @default.
- W4379507980 hasConcept C116569031 @default.
- W4379507980 hasConcept C170493617 @default.
- W4379507980 hasConcept C181199279 @default.
- W4379507980 hasConcept C185592680 @default.
- W4379507980 hasConcept C2776439734 @default.
- W4379507980 hasConcept C3020299119 @default.
- W4379507980 hasConcept C55493867 @default.
- W4379507980 hasConcept C71240020 @default.
- W4379507980 hasConceptScore W4379507980C107824862 @default.
- W4379507980 hasConceptScore W4379507980C116569031 @default.
- W4379507980 hasConceptScore W4379507980C170493617 @default.
- W4379507980 hasConceptScore W4379507980C181199279 @default.
- W4379507980 hasConceptScore W4379507980C185592680 @default.
- W4379507980 hasConceptScore W4379507980C2776439734 @default.
- W4379507980 hasConceptScore W4379507980C3020299119 @default.
- W4379507980 hasConceptScore W4379507980C55493867 @default.
- W4379507980 hasConceptScore W4379507980C71240020 @default.
- W4379507980 hasIssue "15" @default.
- W4379507980 hasLocation W43795079801 @default.
- W4379507980 hasLocation W43795079802 @default.
- W4379507980 hasOpenAccess W4379507980 @default.
- W4379507980 hasPrimaryLocation W43795079801 @default.
- W4379507980 hasRelatedWork W1531601525 @default.
- W4379507980 hasRelatedWork W1683425866 @default.
- W4379507980 hasRelatedWork W1980377213 @default.
- W4379507980 hasRelatedWork W1994905442 @default.
- W4379507980 hasRelatedWork W2017199414 @default.
- W4379507980 hasRelatedWork W2443110026 @default.
- W4379507980 hasRelatedWork W2948807893 @default.
- W4379507980 hasRelatedWork W2952668078 @default.
- W4379507980 hasRelatedWork W59179329 @default.
- W4379507980 hasRelatedWork W2778153218 @default.
- W4379507980 hasVolume "18" @default.
- W4379507980 isParatext "false" @default.
- W4379507980 isRetracted "false" @default.
- W4379507980 workType "article" @default.