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- W4379508043 abstract "Background Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by difficulties in social communication and interaction. Crucial for efficient social interaction is the ability to quickly and accurately extract information from a person's face. Frequency‐tagging electroencephalography (EEG) is a novel tool to quantify face‐processing sensitivity in a robust and implicit manner. In terms of intervention approaches, intranasal administration of oxytocin (OT) is increasingly considered as a potential pharmacological approach for improving socio‐communicative difficulties in ASD, through enhancing social salience and/or reducing (social) stress and anxiety. Methods In this randomized, double‐blind, placebo‐controlled, mechanistic pharmaco‐neuroimaging clinical trial, we implemented frequency‐tagging EEG to conduct an exploratory investigation into the impact of repeated OT administration (4 weeks, 12 IU, twice daily) on neural sensitivity towards happy and fearful facial expressions in children with ASD (8–12 years old; OT: n = 29; placebo: n = 32). Neural effects were assessed at baseline, post‐nasal spray (24 hr after the last nasal spray) and at a follow‐up session, 4 weeks after the OT administration period. At baseline, neural assessments of children with ASD were compared with those of an age‐ and gender‐matched cohort of neurotypical (NT) children ( n = 39). Results Children with ASD demonstrated reduced neural sensitivity towards expressive faces, as compared to NT children. Upon nasal spray administration, children with ASD displayed a significant increase in neural sensitivity at the post‐ and follow‐up sessions, but only in the placebo group, likely reflecting an implicit learning effect. Strikingly, in the OT group, neural sensitivity remained unaffected from the baseline to the post‐session, likely reflecting a dampening of an otherwise typically occurring implicit learning effect. Conclusions First, we validated the robustness of the frequency‐tagging EEG approach to assess reduced neural sensitivity towards expressive faces in children with ASD. Furthermore, in contrast to social salience effects observed after single‐dose administrations, repeated OT administration dampened typically occurring learning effects in neural sensitivity. In line with OT's social anxiolytic account, these observations possibly reflect a predominant (social) stress regulatory effect towards emotionally evocative faces after repeated OT administration." @default.
- W4379508043 created "2023-06-07" @default.
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- W4379508043 date "2023-06-06" @default.
- W4379508043 modified "2023-10-18" @default.
- W4379508043 title "Can repeated intranasal oxytocin administration affect reduced neural sensitivity towards expressive faces in autism? A randomized controlled trial" @default.
- W4379508043 cites W1067107096 @default.
- W4379508043 cites W1823169087 @default.
- W4379508043 cites W1966317054 @default.
- W4379508043 cites W1968228654 @default.
- W4379508043 cites W1968237538 @default.
- W4379508043 cites W1970460214 @default.
- W4379508043 cites W1971519986 @default.
- W4379508043 cites W1977999364 @default.
- W4379508043 cites W1979550412 @default.
- W4379508043 cites W1985576902 @default.
- W4379508043 cites W1993130604 @default.
- W4379508043 cites W1996368170 @default.
- W4379508043 cites W1998476154 @default.
- W4379508043 cites W2001483327 @default.
- W4379508043 cites W2007655600 @default.
- W4379508043 cites W2014187448 @default.
- W4379508043 cites W2014530731 @default.
- W4379508043 cites W2025319978 @default.
- W4379508043 cites W2034453108 @default.
- W4379508043 cites W2038181972 @default.
- W4379508043 cites W2044266604 @default.
- W4379508043 cites W2051491987 @default.
- W4379508043 cites W2051587828 @default.
- W4379508043 cites W2055559081 @default.
- W4379508043 cites W2065016435 @default.
- W4379508043 cites W2070420735 @default.
- W4379508043 cites W2078631866 @default.
- W4379508043 cites W2081758073 @default.
- W4379508043 cites W2097146434 @default.
- W4379508043 cites W2102308037 @default.
- W4379508043 cites W2116280488 @default.
- W4379508043 cites W2121748618 @default.
- W4379508043 cites W2141031554 @default.
- W4379508043 cites W2144745726 @default.
- W4379508043 cites W2149849282 @default.
- W4379508043 cites W2150283722 @default.
- W4379508043 cites W2155600799 @default.
- W4379508043 cites W2178596365 @default.
- W4379508043 cites W2340485469 @default.
- W4379508043 cites W2557098163 @default.
- W4379508043 cites W2606298500 @default.
- W4379508043 cites W2735278545 @default.
- W4379508043 cites W2808328764 @default.
- W4379508043 cites W2886782855 @default.
- W4379508043 cites W2902031403 @default.
- W4379508043 cites W2970612502 @default.
- W4379508043 cites W3004185273 @default.
- W4379508043 cites W3011376691 @default.
- W4379508043 cites W3021249271 @default.
- W4379508043 cites W3086453611 @default.
- W4379508043 cites W3097947239 @default.
- W4379508043 cites W3120256748 @default.
- W4379508043 cites W3135078359 @default.
- W4379508043 cites W3195851944 @default.
- W4379508043 cites W3206744275 @default.
- W4379508043 cites W3212488734 @default.
- W4379508043 cites W4205923272 @default.
- W4379508043 cites W4210970631 @default.
- W4379508043 cites W4220710510 @default.
- W4379508043 cites W4247665917 @default.
- W4379508043 cites W4280590233 @default.
- W4379508043 cites W4366602190 @default.
- W4379508043 cites W812470321 @default.
- W4379508043 doi "https://doi.org/10.1111/jcpp.13850" @default.
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