Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379508304> ?p ?o ?g. }
- W4379508304 endingPage "1012" @default.
- W4379508304 startingPage "1002" @default.
- W4379508304 abstract "Anterior nucleus of thalamus (ANT) has been widely accepted as a potential therapeutic target for drug-resistant epilepsy. Although increased volume of the ANT was also reported in patients with absence epilepsy, the relationship between the ANT and absence epilepsy has been barely illustrated.Using chemogenetics, we evaluated the effect of ANT parvalbumin (PV) neurons on pentylenetetrazole (PTZ)-induced absence seizures in mice.We found that intraperitoneal injection of PTZ (30 mg/kg) can stably induce absence-like seizures characterized by bilaterally synchronous spike-wave discharges (SWDs). Selective activation of PV neurons in the ANT by chemogenetics could aggravate the severity of absence seizures, whereas selective inhibition of that cannot reverse this condition and even promote absence seizures as well. Moreover, chemogenetic inhibition of ANT PV neurons without administration of PTZ was also sufficient to generate SWDs. Analysis of background EEG showed that chemogenetic activation or inhibition of ANT PV neurons could both significantly increase the EEG power of delta oscillation in the frontal cortex, which might mediate the pro-seizure effect of ANT PV neurons.Our findings indicated that either activation or inhibition of ANT PV neurons might disturb the intrinsic delta rhythms in the cortex and worsen absence seizures, which highlighted the importance of maintaining the activity of ANT PV neurons in absence seizure." @default.
- W4379508304 created "2023-06-07" @default.
- W4379508304 creator A5019226774 @default.
- W4379508304 creator A5019899662 @default.
- W4379508304 creator A5024408697 @default.
- W4379508304 creator A5028680526 @default.
- W4379508304 creator A5030029552 @default.
- W4379508304 creator A5031923493 @default.
- W4379508304 creator A5062068787 @default.
- W4379508304 creator A5068038181 @default.
- W4379508304 creator A5069262954 @default.
- W4379508304 date "2023-06-19" @default.
- W4379508304 modified "2023-10-18" @default.
- W4379508304 title "Parvalbumin neurons in the anterior nucleus of thalamus control absence seizures" @default.
- W4379508304 cites W1634443637 @default.
- W4379508304 cites W1963781350 @default.
- W4379508304 cites W1967509521 @default.
- W4379508304 cites W1968172490 @default.
- W4379508304 cites W1974942348 @default.
- W4379508304 cites W1984709734 @default.
- W4379508304 cites W1989486367 @default.
- W4379508304 cites W2002844950 @default.
- W4379508304 cites W2003806209 @default.
- W4379508304 cites W2008953662 @default.
- W4379508304 cites W2014731565 @default.
- W4379508304 cites W2020075364 @default.
- W4379508304 cites W2044777670 @default.
- W4379508304 cites W2051650903 @default.
- W4379508304 cites W2054213975 @default.
- W4379508304 cites W2063464796 @default.
- W4379508304 cites W2074399422 @default.
- W4379508304 cites W2076677921 @default.
- W4379508304 cites W2084072056 @default.
- W4379508304 cites W2123262174 @default.
- W4379508304 cites W2135629133 @default.
- W4379508304 cites W2146434628 @default.
- W4379508304 cites W2156108573 @default.
- W4379508304 cites W2164085110 @default.
- W4379508304 cites W2172144598 @default.
- W4379508304 cites W2176749909 @default.
- W4379508304 cites W2178538195 @default.
- W4379508304 cites W2462138546 @default.
- W4379508304 cites W2560716594 @default.
- W4379508304 cites W2592509339 @default.
- W4379508304 cites W2602352603 @default.
- W4379508304 cites W2602582143 @default.
- W4379508304 cites W2761537021 @default.
- W4379508304 cites W2771435422 @default.
- W4379508304 cites W2903257354 @default.
- W4379508304 cites W2914200390 @default.
- W4379508304 cites W2940794125 @default.
- W4379508304 cites W2971384124 @default.
- W4379508304 cites W3011645338 @default.
- W4379508304 cites W3128254251 @default.
- W4379508304 cites W3193751163 @default.
- W4379508304 cites W4224983143 @default.
- W4379508304 cites W4323652351 @default.
- W4379508304 cites W4379508304 @default.
- W4379508304 doi "https://doi.org/10.1002/epi4.12771" @default.
- W4379508304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37277986" @default.
- W4379508304 hasPublicationYear "2023" @default.
- W4379508304 type Work @default.
- W4379508304 citedByCount "1" @default.
- W4379508304 countsByYear W43795083042023 @default.
- W4379508304 crossrefType "journal-article" @default.
- W4379508304 hasAuthorship W4379508304A5019226774 @default.
- W4379508304 hasAuthorship W4379508304A5019899662 @default.
- W4379508304 hasAuthorship W4379508304A5024408697 @default.
- W4379508304 hasAuthorship W4379508304A5028680526 @default.
- W4379508304 hasAuthorship W4379508304A5030029552 @default.
- W4379508304 hasAuthorship W4379508304A5031923493 @default.
- W4379508304 hasAuthorship W4379508304A5062068787 @default.
- W4379508304 hasAuthorship W4379508304A5068038181 @default.
- W4379508304 hasAuthorship W4379508304A5069262954 @default.
- W4379508304 hasBestOaLocation W43795083041 @default.
- W4379508304 hasConcept C141547260 @default.
- W4379508304 hasConcept C169760540 @default.
- W4379508304 hasConcept C17077164 @default.
- W4379508304 hasConcept C18903297 @default.
- W4379508304 hasConcept C2778186239 @default.
- W4379508304 hasConcept C2779246727 @default.
- W4379508304 hasConcept C2779296341 @default.
- W4379508304 hasConcept C522805319 @default.
- W4379508304 hasConcept C86803240 @default.
- W4379508304 hasConcept C97467695 @default.
- W4379508304 hasConceptScore W4379508304C141547260 @default.
- W4379508304 hasConceptScore W4379508304C169760540 @default.
- W4379508304 hasConceptScore W4379508304C17077164 @default.
- W4379508304 hasConceptScore W4379508304C18903297 @default.
- W4379508304 hasConceptScore W4379508304C2778186239 @default.
- W4379508304 hasConceptScore W4379508304C2779246727 @default.
- W4379508304 hasConceptScore W4379508304C2779296341 @default.
- W4379508304 hasConceptScore W4379508304C522805319 @default.
- W4379508304 hasConceptScore W4379508304C86803240 @default.
- W4379508304 hasConceptScore W4379508304C97467695 @default.
- W4379508304 hasFunder F4320321001 @default.
- W4379508304 hasIssue "3" @default.
- W4379508304 hasLocation W43795083041 @default.