FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379508390> ?p ?o ?g. }

• W4379508390 endingPage "9395" @default.
• W4379508390 startingPage "9388" @default.
• W4379508390 abstract "Strategies for achieving tumor-specific molecular imaging based on signal amplification hold great potential for evaluating the risk of tumor metastasis and progression. However, traditional amplification strategies are still constrained with limited tumor specificity because of the off-tumor signal leakage. Herein, an endogenous enzyme-activated autonomous-motion DNAzyme signal amplification strategy (E-DNAzyme) was rationally designed for tumor-specific molecular imaging with improved spatial specificity. The sensing function of E-DNAzyme can be specifically activated by the overexpressed apurinic/apyrimidinic endonuclease 1 (APE1) in the cytoplasm of tumor cells instead of normal cells, ensuring the tumor cell-specific molecular imaging with improved spatial specificity. Of note, benefiting from the target analogue-triggered autonomous motion of the DNAzyme signal amplification strategy, the detection limit can be decreased by approx. ∼7.8 times. Moreover, the discrimination ratio of tumor/normal cells of the proposed E-DNAzyme was ∼3.44-fold higher than the traditional amplification strategy, indicating the prospect of this universal design for tumor-specific molecular imaging." @default.
• W4379508390 created "2023-06-07" @default.
• W4379508390 creator A5007703244 @default.
• W4379508390 creator A5038851564 @default.
• W4379508390 creator A5048379858 @default.
• W4379508390 creator A5049071926 @default.
• W4379508390 creator A5049287500 @default.
• W4379508390 creator A5054464310 @default.
• W4379508390 creator A5056448190 @default.
• W4379508390 creator A5059658051 @default.
• W4379508390 creator A5062377349 @default.
• W4379508390 date "2023-06-06" @default.
• W4379508390 modified "2023-10-16" @default.
• W4379508390 title "Enzymatically Activated Autonomous-Motion DNAzyme Signal Amplification Strategy for Tumor Cell-Specific Molecular Imaging with Improved Spatial Specificity" @default.
• W4379508390 cites W1968895302 @default.
• W4379508390 cites W1988190543 @default.
• W4379508390 cites W1994357966 @default.
• W4379508390 cites W2002995168 @default.
• W4379508390 cites W2611664377 @default.
• W4379508390 cites W2782940950 @default.
• W4379508390 cites W2791073686 @default.
• W4379508390 cites W2904696155 @default.
• W4379508390 cites W2934692920 @default.
• W4379508390 cites W3013090221 @default.
• W4379508390 cites W3024151971 @default.
• W4379508390 cites W3048988629 @default.
• W4379508390 cites W3118566630 @default.
• W4379508390 cites W3123079813 @default.
• W4379508390 cites W3152815359 @default.
• W4379508390 cites W3158685479 @default.
• W4379508390 cites W3179973808 @default.
• W4379508390 cites W3197515796 @default.
• W4379508390 cites W3204039051 @default.
• W4379508390 cites W3210585456 @default.
• W4379508390 cites W3213745326 @default.
• W4379508390 cites W3215634900 @default.
• W4379508390 cites W4200106787 @default.
• W4379508390 cites W4210668718 @default.
• W4379508390 cites W4220773439 @default.
• W4379508390 cites W4224857494 @default.
• W4379508390 cites W4236463541 @default.
• W4379508390 cites W4246875085 @default.
• W4379508390 cites W4292960896 @default.
• W4379508390 cites W4293124980 @default.
• W4379508390 cites W4295008404 @default.
• W4379508390 cites W4300982291 @default.
• W4379508390 cites W4309244701 @default.
• W4379508390 cites W4309452483 @default.
• W4379508390 doi "https://doi.org/10.1021/acs.analchem.3c01963" @default.
• W4379508390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37279075" @default.
• W4379508390 hasPublicationYear "2023" @default.
• W4379508390 type Work @default.
• W4379508390 citedByCount "1" @default.
• W4379508390 crossrefType "journal-article" @default.
• W4379508390 hasAuthorship W4379508390A5007703244 @default.
• W4379508390 hasAuthorship W4379508390A5038851564 @default.
• W4379508390 hasAuthorship W4379508390A5048379858 @default.
• W4379508390 hasAuthorship W4379508390A5049071926 @default.
• W4379508390 hasAuthorship W4379508390A5049287500 @default.
• W4379508390 hasAuthorship W4379508390A5054464310 @default.
• W4379508390 hasAuthorship W4379508390A5056448190 @default.
• W4379508390 hasAuthorship W4379508390A5059658051 @default.
• W4379508390 hasAuthorship W4379508390A5062377349 @default.
• W4379508390 hasConcept C121608353 @default.
• W4379508390 hasConcept C12554922 @default.
• W4379508390 hasConcept C136339569 @default.
• W4379508390 hasConcept C153911025 @default.
• W4379508390 hasConcept C16613235 @default.
• W4379508390 hasConcept C171250308 @default.
• W4379508390 hasConcept C185592680 @default.
• W4379508390 hasConcept C190062978 @default.
• W4379508390 hasConcept C192562407 @default.
• W4379508390 hasConcept C207001950 @default.
• W4379508390 hasConcept C2779013556 @default.
• W4379508390 hasConcept C54355233 @default.
• W4379508390 hasConcept C552990157 @default.
• W4379508390 hasConcept C55493867 @default.
• W4379508390 hasConcept C61238886 @default.
• W4379508390 hasConcept C84211826 @default.
• W4379508390 hasConcept C86803240 @default.
• W4379508390 hasConcept C95444343 @default.
• W4379508390 hasConceptScore W4379508390C121608353 @default.
• W4379508390 hasConceptScore W4379508390C12554922 @default.
• W4379508390 hasConceptScore W4379508390C136339569 @default.
• W4379508390 hasConceptScore W4379508390C153911025 @default.
• W4379508390 hasConceptScore W4379508390C16613235 @default.
• W4379508390 hasConceptScore W4379508390C171250308 @default.
• W4379508390 hasConceptScore W4379508390C185592680 @default.
• W4379508390 hasConceptScore W4379508390C190062978 @default.
• W4379508390 hasConceptScore W4379508390C192562407 @default.
• W4379508390 hasConceptScore W4379508390C207001950 @default.
• W4379508390 hasConceptScore W4379508390C2779013556 @default.
• W4379508390 hasConceptScore W4379508390C54355233 @default.
• W4379508390 hasConceptScore W4379508390C552990157 @default.
• W4379508390 hasConceptScore W4379508390C55493867 @default.
• W4379508390 hasConceptScore W4379508390C61238886 @default.
• W4379508390 hasConceptScore W4379508390C84211826 @default.
• W4379508390 hasConceptScore W4379508390C86803240 @default.

• next