Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379508700> ?p ?o ?g. }
- W4379508700 endingPage "12600" @default.
- W4379508700 startingPage "12586" @default.
- W4379508700 abstract "Nanozymes have shown great promise in reactive oxygen species (ROS)-mediated tumor therapy with mitigated side effects but are normally limited by the complex tumor microenvironment (TME). Herein, to overcome the adverse effects of TME, such as tumor hypoxia and high endogenous glutathione (GSH), an aptamer-functionalized Pd@MoO3-x nano-hydrangea (A-Pd@MoO3-x NH) is constructed for high-efficiency cancer therapy. Utilizing the irregular shape characteristics of nano Pd, the A-Pd@MoO3-x NH nanozyme simultaneously exposes catalase-like Pd(111) and oxidase-like Pd(100) surface facets as dual active centers. This can catalyze cascade enzymatic reactions to overcome the negative effects of tumor hypoxia caused by the accumulation of cytotoxic superoxide (O2•-) radicals in TME without any external stimuli. In addition, the nanozyme can effectively degrade the overexpressed glutathione (GSH) through the redox reaction to avoid nontherapeutic consumption of O2•- radicals. More significantly, as a reversible electron station, MoO3-x can extract electrons from H2O2 decomposing on Pd(111) or GSH degradation and transfer them back to Pd(100) through oxygen bridges or few Mo-Pd bonds. This can synergistically enhance enzyme-like activities of dual active centers and the GSH-degrading ability to enrich O2•- radicals. In this way, the A-Pd@MoO3-x NH nanozyme can selectively and remarkably kill tumor cells while keeping the normal cell line unharmed." @default.
- W4379508700 created "2023-06-07" @default.
- W4379508700 creator A5006138591 @default.
- W4379508700 creator A5013617878 @default.
- W4379508700 creator A5024591419 @default.
- W4379508700 creator A5040142959 @default.
- W4379508700 creator A5052365065 @default.
- W4379508700 creator A5053204257 @default.
- W4379508700 creator A5074317955 @default.
- W4379508700 creator A5089144553 @default.
- W4379508700 creator A5090927094 @default.
- W4379508700 date "2023-06-06" @default.
- W4379508700 modified "2023-10-14" @default.
- W4379508700 title "Dual Active Centers Linked by a Reversible Electron Station as a Multifunctional Nanozyme to Induce Synergetically Enhanced Cascade Catalysis for Tumor-Specific Therapy" @default.
- W4379508700 cites W1895381877 @default.
- W4379508700 cites W1978727146 @default.
- W4379508700 cites W1991952977 @default.
- W4379508700 cites W2001746593 @default.
- W4379508700 cites W2012334270 @default.
- W4379508700 cites W2024903578 @default.
- W4379508700 cites W2066068527 @default.
- W4379508700 cites W2107853095 @default.
- W4379508700 cites W2157901256 @default.
- W4379508700 cites W2314025028 @default.
- W4379508700 cites W2509098156 @default.
- W4379508700 cites W2529562623 @default.
- W4379508700 cites W2550440327 @default.
- W4379508700 cites W2610182885 @default.
- W4379508700 cites W2737866071 @default.
- W4379508700 cites W2747423355 @default.
- W4379508700 cites W2781645611 @default.
- W4379508700 cites W2807842448 @default.
- W4379508700 cites W2887163385 @default.
- W4379508700 cites W2887832992 @default.
- W4379508700 cites W2901690833 @default.
- W4379508700 cites W2943029133 @default.
- W4379508700 cites W2943815248 @default.
- W4379508700 cites W2947512353 @default.
- W4379508700 cites W2955231196 @default.
- W4379508700 cites W2966403049 @default.
- W4379508700 cites W2969496741 @default.
- W4379508700 cites W2969772976 @default.
- W4379508700 cites W2979380254 @default.
- W4379508700 cites W2986752244 @default.
- W4379508700 cites W2986779427 @default.
- W4379508700 cites W2990889125 @default.
- W4379508700 cites W2996248552 @default.
- W4379508700 cites W2998560245 @default.
- W4379508700 cites W3004451879 @default.
- W4379508700 cites W3012213195 @default.
- W4379508700 cites W3016749548 @default.
- W4379508700 cites W3084074356 @default.
- W4379508700 cites W3084621691 @default.
- W4379508700 cites W3112908150 @default.
- W4379508700 cites W3128836147 @default.
- W4379508700 cites W3135372736 @default.
- W4379508700 cites W3158571905 @default.
- W4379508700 cites W3167233687 @default.
- W4379508700 cites W3171430542 @default.
- W4379508700 cites W3174128215 @default.
- W4379508700 cites W3178086018 @default.
- W4379508700 cites W3183187970 @default.
- W4379508700 cites W3190079234 @default.
- W4379508700 cites W3195294650 @default.
- W4379508700 cites W3212348515 @default.
- W4379508700 cites W4210795205 @default.
- W4379508700 cites W4280585895 @default.
- W4379508700 cites W4283701282 @default.
- W4379508700 cites W4285012964 @default.
- W4379508700 cites W4285085918 @default.
- W4379508700 cites W4291814891 @default.
- W4379508700 cites W4315646719 @default.
- W4379508700 doi "https://doi.org/10.1021/jacs.3c01532" @default.
- W4379508700 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37277963" @default.
- W4379508700 hasPublicationYear "2023" @default.
- W4379508700 type Work @default.
- W4379508700 citedByCount "2" @default.
- W4379508700 countsByYear W43795087002023 @default.
- W4379508700 crossrefType "journal-article" @default.
- W4379508700 hasAuthorship W4379508700A5006138591 @default.
- W4379508700 hasAuthorship W4379508700A5013617878 @default.
- W4379508700 hasAuthorship W4379508700A5024591419 @default.
- W4379508700 hasAuthorship W4379508700A5040142959 @default.
- W4379508700 hasAuthorship W4379508700A5052365065 @default.
- W4379508700 hasAuthorship W4379508700A5053204257 @default.
- W4379508700 hasAuthorship W4379508700A5074317955 @default.
- W4379508700 hasAuthorship W4379508700A5089144553 @default.
- W4379508700 hasAuthorship W4379508700A5090927094 @default.
- W4379508700 hasConcept C12554922 @default.
- W4379508700 hasConcept C126322002 @default.
- W4379508700 hasConcept C139066938 @default.
- W4379508700 hasConcept C161790260 @default.
- W4379508700 hasConcept C181199279 @default.
- W4379508700 hasConcept C185592680 @default.
- W4379508700 hasConcept C2776107976 @default.
- W4379508700 hasConcept C2778004101 @default.
- W4379508700 hasConcept C2778979269 @default.
- W4379508700 hasConcept C2779081379 @default.