Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379508826> ?p ?o ?g. }
- W4379508826 abstract "Anthracyclines and cytarabine have comprised standard induction therapy for acute myeloid leukemia (AML) for decades. Low overall survival of AML is due to non-remission or relapse after remission. Hypomethylating agent (HMA) decitabine combined with low-dose chemotherapy or other targeted agents has shown promising effect for AML in clinical trials, especially in t(8;21) acute myeloid leukemia. We previously investigated histone deacetylase inhibitor (HDACi) chidamide could regulate Wnt/β-catenin signaling pathway in leukemia cell lines.Adult patients with de novo or relapsed/refractory AML who were treated with chidamide and decitabine in combination with chemotherapy (chidamide group, n = 23) or only decitabine combination with chemotherapy (decitabine group, n = 17) were analyzed.Chidamide group represented higher complete response rate (82.6% and 52.9%, p = 0.0430, vs. decitabine group), progression-free survival and overall survival rates (p = 0.0088 and p = 0.0139, respectively), especially for patients with de novo AML. Hematological toxicity and infections were the most common adverse events (AEs) in both groups, and they were manageable by supportive treatments.This HDACi- and HMA-based protocol is an effective and tolerable therapy for patients with AML. The comprehensive mechanism and effects of chidamide in combination with decitabine are worth to be further explored in AML." @default.
- W4379508826 created "2023-06-07" @default.
- W4379508826 creator A5004138380 @default.
- W4379508826 creator A5013551827 @default.
- W4379508826 creator A5026132851 @default.
- W4379508826 creator A5026412721 @default.
- W4379508826 creator A5026885445 @default.
- W4379508826 creator A5033972653 @default.
- W4379508826 creator A5058245642 @default.
- W4379508826 creator A5058614577 @default.
- W4379508826 creator A5061435618 @default.
- W4379508826 creator A5062019087 @default.
- W4379508826 creator A5089521888 @default.
- W4379508826 creator A5091130757 @default.
- W4379508826 creator A5092096096 @default.
- W4379508826 date "2023-06-06" @default.
- W4379508826 modified "2023-09-26" @default.
- W4379508826 title "Efficacy and safety of an HDACi- and HMA-based protocol in adults with acute myeloid leukemia of intermediate- and adverse-risk categories: a retrospective study" @default.
- W4379508826 cites W1255676896 @default.
- W4379508826 cites W1984814872 @default.
- W4379508826 cites W2027171343 @default.
- W4379508826 cites W2038248421 @default.
- W4379508826 cites W2075709249 @default.
- W4379508826 cites W2098298980 @default.
- W4379508826 cites W2101366183 @default.
- W4379508826 cites W2107684775 @default.
- W4379508826 cites W2125482846 @default.
- W4379508826 cites W2237124828 @default.
- W4379508826 cites W2313888337 @default.
- W4379508826 cites W2339658711 @default.
- W4379508826 cites W2412183643 @default.
- W4379508826 cites W2419140434 @default.
- W4379508826 cites W2559537906 @default.
- W4379508826 cites W2589386142 @default.
- W4379508826 cites W2795208162 @default.
- W4379508826 cites W2805590406 @default.
- W4379508826 cites W2887033855 @default.
- W4379508826 cites W2896849737 @default.
- W4379508826 cites W2901949277 @default.
- W4379508826 cites W2930138051 @default.
- W4379508826 cites W2942855506 @default.
- W4379508826 cites W2963513172 @default.
- W4379508826 cites W2972405358 @default.
- W4379508826 cites W2980094806 @default.
- W4379508826 cites W2986834274 @default.
- W4379508826 cites W3006173252 @default.
- W4379508826 cites W3024717660 @default.
- W4379508826 cites W3082177268 @default.
- W4379508826 cites W3112156395 @default.
- W4379508826 cites W3126958487 @default.
- W4379508826 cites W3137559923 @default.
- W4379508826 cites W3161758529 @default.
- W4379508826 cites W4200383314 @default.
- W4379508826 cites W4210639259 @default.
- W4379508826 cites W4229018428 @default.
- W4379508826 cites W4304688270 @default.
- W4379508826 cites W4310493914 @default.
- W4379508826 doi "https://doi.org/10.1080/16078454.2023.2219930" @default.
- W4379508826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37278601" @default.
- W4379508826 hasPublicationYear "2023" @default.
- W4379508826 type Work @default.
- W4379508826 citedByCount "0" @default.
- W4379508826 crossrefType "journal-article" @default.
- W4379508826 hasAuthorship W4379508826A5004138380 @default.
- W4379508826 hasAuthorship W4379508826A5013551827 @default.
- W4379508826 hasAuthorship W4379508826A5026132851 @default.
- W4379508826 hasAuthorship W4379508826A5026412721 @default.
- W4379508826 hasAuthorship W4379508826A5026885445 @default.
- W4379508826 hasAuthorship W4379508826A5033972653 @default.
- W4379508826 hasAuthorship W4379508826A5058245642 @default.
- W4379508826 hasAuthorship W4379508826A5058614577 @default.
- W4379508826 hasAuthorship W4379508826A5061435618 @default.
- W4379508826 hasAuthorship W4379508826A5062019087 @default.
- W4379508826 hasAuthorship W4379508826A5089521888 @default.
- W4379508826 hasAuthorship W4379508826A5091130757 @default.
- W4379508826 hasAuthorship W4379508826A5092096096 @default.
- W4379508826 hasBestOaLocation W43795088261 @default.
- W4379508826 hasConcept C104317684 @default.
- W4379508826 hasConcept C126322002 @default.
- W4379508826 hasConcept C143998085 @default.
- W4379508826 hasConcept C150194340 @default.
- W4379508826 hasConcept C190727270 @default.
- W4379508826 hasConcept C197934379 @default.
- W4379508826 hasConcept C2776239401 @default.
- W4379508826 hasConcept C2776694085 @default.
- W4379508826 hasConcept C2778041864 @default.
- W4379508826 hasConcept C2778461978 @default.
- W4379508826 hasConcept C2778729363 @default.
- W4379508826 hasConcept C2780235182 @default.
- W4379508826 hasConcept C55493867 @default.
- W4379508826 hasConcept C71924100 @default.
- W4379508826 hasConcept C86803240 @default.
- W4379508826 hasConceptScore W4379508826C104317684 @default.
- W4379508826 hasConceptScore W4379508826C126322002 @default.
- W4379508826 hasConceptScore W4379508826C143998085 @default.
- W4379508826 hasConceptScore W4379508826C150194340 @default.
- W4379508826 hasConceptScore W4379508826C190727270 @default.
- W4379508826 hasConceptScore W4379508826C197934379 @default.
- W4379508826 hasConceptScore W4379508826C2776239401 @default.
- W4379508826 hasConceptScore W4379508826C2776694085 @default.