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- W4379514231 abstract "The blood-brain barrier (BBB) controls the movement of molecules into and out of the central nervous system (CNS). Since a functional BBB forms by mouse embryonic day E15.5, we reasoned that gene cohorts expressed in CNS endothelial cells (EC) at E13.5 contribute to BBB formation, whereas adult gene signatures reflect BBB maintenance mechanisms. Supporting this hypothesis, transcriptomic analysis revealed distinct cohorts of EC genes during BBB formation and maintenance. Here we demonstrate that epigenetic regulator’s histone deacetylase 2 (HDAC2) and polycomb repressive complex 2 (PRC2) control EC gene expression for BBB development and prevented Wnt/β-catenin (Wnt) target genes from being expressed in adult CNS ECs. Low Wnt activity during development modifies BBB genes epigenetically for the formation of functional BBB. As a Class-I HDAC inhibitor induces adult CNS ECs to regain Wnt activity and BBB genetic signatures that support BBB formation, our results inform strategies to promote BBB repair." @default.
- W4379514231 created "2023-06-07" @default.
- W4379514231 date "2023-06-06" @default.
- W4379514231 modified "2023-09-27" @default.
- W4379514231 title "Reviewer #1 (Public Review): Establishing And Maintaining The Blood-Brain Barrier: Epigenetic And Signaling Determinants" @default.
- W4379514231 doi "https://doi.org/10.7554/elife.86978.1.sa1" @default.
- W4379514231 hasPublicationYear "2023" @default.
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