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- W4379516479 abstract "Abstract: Background: Baclofen is used as skeletal muscle relaxant. Baclofen inhibit Polysynaptic and monosynaptic reflexes a hyperpolarisation. Baclofen drug absorbed rapidly and excreted in feces urine in unchanged form. Objectives: Aim of the current study was to formulate sustained release mucoadhesive microcapsules of Baclofen using different polymers like Chitosan, Carbopol934P, HPMC K4M. Materials and Methods: Ionotropic gelation method was used for preparation of microcapsules of baclofen. Dispersion of polymers and baclofen was dropwise added sodium tripolyphosphate solution to form microcapsule. The prepared microcapsules were evaluated for FTIR studies, micromeritic properties, drug entrapment efficiency, particle size and shape, SEM, swelling index, mucoadhesive strength, in vitro release studies. Results: Angle of repose of prepared microcapsules was in range 24.48 ± 1.39 to 38.08±1.67 showed good flowability. Prepared microcapsules showed bulk density in the range of 0.49±0.04 to1.22±0.06. All formulations showed Carr’s index and Hausner’s ratio in the range of 14.68 ±1.20 to 29.56 ± 1.97 and 1.16±0.012 to 1.25±0.016 respectively. Formulation F1 to F3 prepared with HPMC (K4M) showed drug release 77.78%, 74.94%, 77.99% and formulation F4 to F6 prepared with Carbopol 934P showed drug release 78.20%, 79.05%, 87.48% respectively in 12hr. Conclusion: Sustained release profile F6 formulation was obtained due to significant mucoadhesive efficiency of the Carbopol 934P. Hence the mucoadhesive microcapsules of Baclofen would be an effective strategy for the management of Muscle Pain. Keywords: Baclofen, Microcapsule, Carbopol 934P, HPMC K4M, Sustained Release." @default.
- W4379516479 created "2023-06-07" @default.
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- W4379516479 date "2023-06-05" @default.
- W4379516479 modified "2023-09-30" @default.
- W4379516479 title "Formulation and Characterization Sustained Release Mucoadhesive Microcapsule of Baclofen" @default.
- W4379516479 doi "https://doi.org/10.5530/ijper.57.2s.28" @default.
- W4379516479 hasPublicationYear "2023" @default.
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