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- W4379523327 abstract "Abstract Many evidences confirm that CSC plays an important role in tumorigenesis and drug resistance. As a member of the forkhead frame(FOX)family, FOXC1 plays a significant role in embryonic development and organogenesis. In addition, FOXC1 has been shown to be overexpressed as a transcription factor in a variety of tumors, promoting the proliferation, migration ability, drug resistance, and maintaining stem-cell like properties. However, there are few studies on its role in ESCC. We found that FOXC1 expression was upregulated in ESCC and correlated with poor prognosis. Downregulation of FOXC1 inhibited ESCC tumorigenesis, proliferative ability, and tolerance to chemotherapeutic agents, while reducing the expression of stemness-related markers CD44 and CD133. Further studies verified that FOXC1 induced ESCC stemness by transactivating of CBX7 and IGF-1R. In addition, IGF-1 activated PI3K/AKT/NF-κB and MEK/ERK/NF-κB pathways by binding to IGF-1R which increased FOXC1 expression. Conversely, suppressing FOXC1 impeded the ESCC stemness induced by IGF-1. A positive feedback loop of IGF-1-FOXC1-IGF-1R is present, which suggests that FOXC1 could serve as a prognostic biomarker for ESCC. Additionally, targeting IGF-1-FOXC1-IGF-1R may be a promising approach for anti-CSC therapy in ESCC." @default.
- W4379523327 created "2023-06-07" @default.
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- W4379523327 date "2023-06-06" @default.
- W4379523327 modified "2023-10-14" @default.
- W4379523327 title "IGF-1-mediated FOXC1 overexpression induces stem-like properties through upregulating CBX7 and IGF-1R in esophageal squamous cell carcinoma" @default.
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- W4379523327 doi "https://doi.org/10.21203/rs.3.rs-2922693/v1" @default.
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