Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379536691> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W4379536691 abstract "The blood-brain barrier (BBB) controls the movement of molecules into and out of the central nervous system (CNS). Since a functional BBB forms by mouse embryonic day E15.5, we reasoned that gene cohorts expressed in CNS endothelial cells (EC) at E13.5 contribute to BBB formation, whereas adult gene signatures reflect BBB maintenance mechanisms. Supporting this hypothesis, transcriptomic analysis revealed distinct cohorts of EC genes during BBB formation and maintenance. Here we demonstrate that epigenetic regulator’s histone deacetylase 2 (HDAC2) and polycomb repressive complex 2 (PRC2) control EC gene expression for BBB development and prevented Wnt/β-catenin (Wnt) target genes from being expressed in adult CNS ECs. Low Wnt activity during development modifies BBB genes epigenetically for the formation of functional BBB. As a Class-I HDAC inhibitor induces adult CNS ECs to regain Wnt activity and BBB genetic signatures that support BBB formation, our results inform strategies to promote BBB repair." @default.
- W4379536691 created "2023-06-07" @default.
- W4379536691 creator A5076668510 @default.
- W4379536691 date "2023-06-06" @default.
- W4379536691 modified "2023-09-23" @default.
- W4379536691 title "eLife assessment: Establishing And Maintaining The Blood-Brain Barrier: Epigenetic And Signaling Determinants" @default.
- W4379536691 doi "https://doi.org/10.7554/elife.86978.1.sa0" @default.
- W4379536691 hasPublicationYear "2023" @default.
- W4379536691 type Work @default.
- W4379536691 citedByCount "0" @default.
- W4379536691 crossrefType "peer-review" @default.
- W4379536691 hasAuthorship W4379536691A5076668510 @default.
- W4379536691 hasBestOaLocation W43795366911 @default.
- W4379536691 hasConcept C104317684 @default.
- W4379536691 hasConcept C137620995 @default.
- W4379536691 hasConcept C150194340 @default.
- W4379536691 hasConcept C162317418 @default.
- W4379536691 hasConcept C169760540 @default.
- W4379536691 hasConcept C2776202225 @default.
- W4379536691 hasConcept C2778305200 @default.
- W4379536691 hasConcept C41091548 @default.
- W4379536691 hasConcept C529278444 @default.
- W4379536691 hasConcept C54355233 @default.
- W4379536691 hasConcept C64927066 @default.
- W4379536691 hasConcept C71723506 @default.
- W4379536691 hasConcept C86803240 @default.
- W4379536691 hasConcept C95444343 @default.
- W4379536691 hasConceptScore W4379536691C104317684 @default.
- W4379536691 hasConceptScore W4379536691C137620995 @default.
- W4379536691 hasConceptScore W4379536691C150194340 @default.
- W4379536691 hasConceptScore W4379536691C162317418 @default.
- W4379536691 hasConceptScore W4379536691C169760540 @default.
- W4379536691 hasConceptScore W4379536691C2776202225 @default.
- W4379536691 hasConceptScore W4379536691C2778305200 @default.
- W4379536691 hasConceptScore W4379536691C41091548 @default.
- W4379536691 hasConceptScore W4379536691C529278444 @default.
- W4379536691 hasConceptScore W4379536691C54355233 @default.
- W4379536691 hasConceptScore W4379536691C64927066 @default.
- W4379536691 hasConceptScore W4379536691C71723506 @default.
- W4379536691 hasConceptScore W4379536691C86803240 @default.
- W4379536691 hasConceptScore W4379536691C95444343 @default.
- W4379536691 hasLocation W43795366911 @default.
- W4379536691 hasOpenAccess W4379536691 @default.
- W4379536691 hasPrimaryLocation W43795366911 @default.
- W4379536691 hasRelatedWork W1992075788 @default.
- W4379536691 hasRelatedWork W2316328445 @default.
- W4379536691 hasRelatedWork W2511725000 @default.
- W4379536691 hasRelatedWork W2552712024 @default.
- W4379536691 hasRelatedWork W2563611942 @default.
- W4379536691 hasRelatedWork W3126958487 @default.
- W4379536691 hasRelatedWork W4310368055 @default.
- W4379536691 hasRelatedWork W4318477855 @default.
- W4379536691 hasRelatedWork W4379514089 @default.
- W4379536691 hasRelatedWork W4379514231 @default.
- W4379536691 isParatext "false" @default.
- W4379536691 isRetracted "false" @default.
- W4379536691 workType "peer-review" @default.