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Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379598311> ?p ?o ?g. }

• W4379598311 endingPage "2236" @default.
• W4379598311 startingPage "2228" @default.
• W4379598311 abstract "Point-of-care tests (POCTs) are increasingly being used in field settings, particularly outdoors. The performance of current POCTs─most commonly the lateral flow immunoassay─can be adversely affected by ambient temperature and humidity. We developed a self-contained immunoassay platform─the D4 POCT─that can be conducted at the POC by integrating all reagents in a capillary-driven passive microfluidic cassette that minimizes user intervention. The assay can be imaged and analyzed on a portable fluorescence reader─the D4Scope─and provide quantitative outputs. Here, we systematically investigated the resilience of our D4 POCT to varied temperature and humidity and to physiologically diverse human whole blood samples that span a wide range of physiological hematocrit (30–65%). For all conditions, we showed that the platform maintained high sensitivity (0.05–0.41 ng/mL limits of detection). The platform also demonstrated good accuracy in reporting true analyte concentration across environmental extremes when compared to the manually operated format of the same test to detect a model analyte─ovalbumin. Additionally, we engineered an improved version of the microfluidic cassette that improved the ease-of-use of the device and shortened the time-to-result. We implemented this new cassette to create a rapid diagnostic test to detect talaromycosis infection in patients with advanced HIV disease at the POC, demonstrating comparable sensitivity and specificity to the laboratory test for the disease." @default.
• W4379598311 created "2023-06-08" @default.
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• W4379598311 date "2023-06-06" @default.
• W4379598311 modified "2023-10-14" @default.
• W4379598311 title "Environmentally Resilient Microfluidic Point-of-Care Immunoassay Enables Rapid Diagnosis of Talaromycosis" @default.
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• W4379598311 doi "https://doi.org/10.1021/acssensors.3c00209" @default.
• W4379598311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37279466" @default.
• W4379598311 hasPublicationYear "2023" @default.
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