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• W4379598539 endingPage "473" @default.
• W4379598539 startingPage "453" @default.
• W4379598539 abstract "The rate of substance use is rising, especially among reproductive-age individuals. Emerging evidence suggests that paternal pre-conception and maternal prenatal substance use may alter offspring epigenetic regulation (changes to gene expression without modifying DNA) and outcomes later in life, including neurodevelopment and mental health. However, relatively little is known due to the complexities and limitations of existing studies, making causal interpretations challenging. This review examines the contributions and influence of parental substance use on the gametes and potential transmissibility to the offspring’s epigenome as possible areas to target public health warnings and healthcare provider counseling of individuals or couples in the pre-conception and prenatal periods to ultimately mitigate short- and long-term offspring morbidity and mortality." @default.
• W4379598539 created "2023-06-08" @default.
• W4379598539 creator A5042143593 @default.
• W4379598539 creator A5056248802 @default.
• W4379598539 creator A5056466210 @default.
• W4379598539 creator A5080664272 @default.
• W4379598539 creator A5092103971 @default.
• W4379598539 date "2023-04-01" @default.
• W4379598539 modified "2023-09-25" @default.
• W4379598539 title "An epigenetic synopsis of parental substance use" @default.
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