Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379600172> ?p ?o ?g. }
- W4379600172 endingPage "3743" @default.
- W4379600172 startingPage "3724" @default.
- W4379600172 abstract "Abstract P38 mitogen‐activated protein kinase (p38 MAPK) signaling pathway is closely related to severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) replication and hyperinflammatory responses in coronavirus disease 2019 (COVID‐19). Therefore, blood–brain barrier‐penetrating p38 MAPK inhibitors have good potential for the treatment of central nervous system (CNS) complications of COVID‐19. The aim of the present study is the characterization of the therapeutic potential of tanshinone IIA and pinocembrin for the treatment of CNS complications of COVID‐19. Studies published in high‐quality journals indexed in databases Scopus, Web of Science, PubMed, and so forth were used to review the therapeutic capabilities of selected compounds. In continuation of our previous efforts to identify agents with favorable activity/toxicity profiles for the treatment of COVID‐19, tanshinone IIA and pinocembrin were identified with a high ability to penetrate the CNS. Considering the nature of the study, no specific time frame was determined for the selection of studies, but the focus was strongly on studies published after the emergence of COVID‐19. By describing the association of COVID‐19‐induced CNS disorders with p38 MAPK pathway disruption, this study concludes that tanshinone IIA and pinocembrin have great potential for better treatment of these complications. The inclusion of these compounds in the drug regimen of COVID‐19 patients requires confirmation of their effectiveness through the conduction of high‐quality clinical trials." @default.
- W4379600172 created "2023-06-08" @default.
- W4379600172 creator A5038302232 @default.
- W4379600172 date "2023-06-06" @default.
- W4379600172 modified "2023-10-17" @default.
- W4379600172 title "Therapeutic prospects of naturally occurring p38 <scp>MAPK</scp> inhibitors tanshinone <scp>IIA</scp> and pinocembrin for the treatment of <scp>SARS‐CoV</scp>‐2‐induced <scp>CNS</scp> complications" @default.
- W4379600172 cites W1121929814 @default.
- W4379600172 cites W1963645640 @default.
- W4379600172 cites W1967477151 @default.
- W4379600172 cites W1968190936 @default.
- W4379600172 cites W1968286122 @default.
- W4379600172 cites W1969067003 @default.
- W4379600172 cites W1971308414 @default.
- W4379600172 cites W1972304405 @default.
- W4379600172 cites W1973502959 @default.
- W4379600172 cites W1983830700 @default.
- W4379600172 cites W1984658969 @default.
- W4379600172 cites W1989173654 @default.
- W4379600172 cites W1996719014 @default.
- W4379600172 cites W2002393195 @default.
- W4379600172 cites W2016385757 @default.
- W4379600172 cites W2019543997 @default.
- W4379600172 cites W2020896146 @default.
- W4379600172 cites W2029663297 @default.
- W4379600172 cites W2036739898 @default.
- W4379600172 cites W2043047155 @default.
- W4379600172 cites W2044591969 @default.
- W4379600172 cites W2059617137 @default.
- W4379600172 cites W2062010118 @default.
- W4379600172 cites W2064572306 @default.
- W4379600172 cites W2065680172 @default.
- W4379600172 cites W2065913569 @default.
- W4379600172 cites W2065925255 @default.
- W4379600172 cites W2067986464 @default.
- W4379600172 cites W2074981365 @default.
- W4379600172 cites W2080625218 @default.
- W4379600172 cites W2081130105 @default.
- W4379600172 cites W2081838607 @default.
- W4379600172 cites W2085109799 @default.
- W4379600172 cites W2085410427 @default.
- W4379600172 cites W2088114116 @default.
- W4379600172 cites W2090390222 @default.
- W4379600172 cites W2100887803 @default.
- W4379600172 cites W2107446848 @default.
- W4379600172 cites W2111412754 @default.
- W4379600172 cites W2133827803 @default.
- W4379600172 cites W2135349567 @default.
- W4379600172 cites W2149848093 @default.
- W4379600172 cites W2158692880 @default.
- W4379600172 cites W2164434965 @default.
- W4379600172 cites W2170104881 @default.
- W4379600172 cites W2182357122 @default.
- W4379600172 cites W2182743236 @default.
- W4379600172 cites W2191253512 @default.
- W4379600172 cites W2498439654 @default.
- W4379600172 cites W2547178274 @default.
- W4379600172 cites W2593436234 @default.
- W4379600172 cites W2601494682 @default.
- W4379600172 cites W2609691520 @default.
- W4379600172 cites W2622736551 @default.
- W4379600172 cites W2756530729 @default.
- W4379600172 cites W2768408309 @default.
- W4379600172 cites W2799598109 @default.
- W4379600172 cites W2802143380 @default.
- W4379600172 cites W2809383046 @default.
- W4379600172 cites W2883636663 @default.
- W4379600172 cites W2893327220 @default.
- W4379600172 cites W2911173386 @default.
- W4379600172 cites W2920957051 @default.
- W4379600172 cites W2924423148 @default.
- W4379600172 cites W2938416610 @default.
- W4379600172 cites W2952224173 @default.
- W4379600172 cites W2952300692 @default.
- W4379600172 cites W2966239380 @default.
- W4379600172 cites W2972998234 @default.
- W4379600172 cites W2976901289 @default.
- W4379600172 cites W2985480800 @default.
- W4379600172 cites W2989470675 @default.
- W4379600172 cites W2994874790 @default.
- W4379600172 cites W2998524869 @default.
- W4379600172 cites W3013139410 @default.
- W4379600172 cites W3015190630 @default.
- W4379600172 cites W3019998044 @default.
- W4379600172 cites W3025943349 @default.
- W4379600172 cites W3029606718 @default.
- W4379600172 cites W3037043141 @default.
- W4379600172 cites W3043105516 @default.
- W4379600172 cites W3043229273 @default.
- W4379600172 cites W3080546252 @default.
- W4379600172 cites W3081936186 @default.
- W4379600172 cites W3084137976 @default.
- W4379600172 cites W3085495358 @default.
- W4379600172 cites W3092552662 @default.
- W4379600172 cites W3092681649 @default.
- W4379600172 cites W3092736134 @default.
- W4379600172 cites W3093228220 @default.
- W4379600172 cites W3093862692 @default.
- W4379600172 cites W3110752337 @default.