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• W4379600177 abstract "Background: Safe and effective wound healing can be a major clinical challenge. Inflammation and vascular impairment are two main causes of inadequate wound healing. Methods: Here, we developed a versatile hydrogel wound dressing, comprising a straightforward physical mixture of royal jelly-derived extracellular vesicles (RJ-EVs) and methacrylic anhydride modified sericin (SerMA), to accelerate wound healing by inhibiting inflammation and promoting vascular reparation. Results: The RJ-EVs showed satisfactory anti-inflammatory and antioxidant effects, and significantly promoted L929 cell proliferation and migration in vitro. Meanwhile, the photocrosslinked SerMA hydrogel with its porous interior structure and high fluidity made it a good candidate for wound dressing. The RJ-EVs can be gradually released from the SerMA hydrogel at the wound site, ensuring the restorative effect of RJ-EVs. In a full-thickness skin defect model, the SerMA/RJ-EVs hydrogel dressing accelerated wound healing with a healing rate of 96.8% by improving cell proliferation and angiogenesis. The RNA sequencing results further revealed that the SerMA/RJ-EVs hydrogel dressing was involved in inflammatory damage repair-related pathways including recombinational repair, epidermis development, and Wnt signaling. Conclusion: This SerMA/RJ-EVs hydrogel dressing offers a simple, safe and robust strategy for modulating inflammation and vascular impairment for accelerated wound healing." @default.
• W4379600177 created "2023-06-08" @default.
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• W4379600177 date "2023-01-01" @default.
• W4379600177 modified "2023-10-04" @default.
• W4379600177 title "<i>In situ</i> formed scaffold with royal jelly-derived extracellular vesicles for wound healing" @default.
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• W4379600177 doi "https://doi.org/10.7150/thno.84665" @default.
• W4379600177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37284440" @default.
• W4379600177 hasPublicationYear "2023" @default.
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