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- W4379600250 abstract "The diverse GTPases of the dynamin superfamily play various roles in the cell, as exemplified by the dynamin-related proteins (DRPs) Mgm1 and Opa1, which remodel the mitochondrial inner membrane in fungi and metazoans, respectively. Via an exhaustive search of genomic and metagenomic databases, we found previously unknown DRP types occurring in diverse eukaryotes and giant viruses (phylum Nucleocytoviricota). One novel DRP clade, termed MidX, combined hitherto uncharacterized proteins from giant viruses and six distantly related eukaryote taxa (Stramenopiles, Telonemia, Picozoa, Amoebozoa, Apusomonadida, and Choanoflagellata). MidX stood out because it was not only predicted to be mitochondria-targeted but also to assume a tertiary structure not observed in other DRPs before. To understand how MidX affects mitochondria, we exogenously expressed MidX from Hyperionvirus in the kinetoplastid Trypanosoma brucei, which lacks Mgm1 or Opa1 orthologs. MidX massively affected mitochondrial morphology from inside the matrix, where it closely associates with the inner membrane. This unprecedented mode of action contrasts to those of Mgm1 and Opa1, which mediate inner membrane remodeling in the intermembrane space. We speculate that MidX was acquired in Nucleocytoviricota evolution by horizontal gene transfer from eukaryotes and is used by giant viruses to remodel host mitochondria during infection. MidX's unique structure may be an adaptation for reshaping mitochondria from the inside. Finally, Mgm1 forms a sister group to MidX and not Opa1 in our phylogenetic analysis, throwing into question the long-presumed homology of these DRPs with similar roles in sister lineages." @default.
- W4379600250 created "2023-06-08" @default.
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- W4379600250 date "2023-06-01" @default.
- W4379600250 modified "2023-10-03" @default.
- W4379600250 title "A Novel Group of Dynamin-Related Proteins Shared by Eukaryotes and Giant Viruses Is Able to Remodel Mitochondria From Within the Matrix" @default.
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- W4379600250 cites W2038335468 @default.
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- W4379600250 cites W2130060890 @default.
- W4379600250 cites W2138122982 @default.
- W4379600250 cites W2152770371 @default.
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- W4379600250 cites W2922326472 @default.
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- W4379600250 cites W2960011603 @default.
- W4379600250 cites W2966270208 @default.
- W4379600250 cites W2977355839 @default.
- W4379600250 cites W2977368063 @default.
- W4379600250 cites W2977630158 @default.
- W4379600250 cites W2980251061 @default.
- W4379600250 cites W2995416556 @default.
- W4379600250 cites W3002419408 @default.
- W4379600250 cites W3005235420 @default.
- W4379600250 cites W3006567658 @default.
- W4379600250 cites W3010256223 @default.
- W4379600250 cites W3012927825 @default.
- W4379600250 cites W3013603319 @default.
- W4379600250 cites W3014884580 @default.
- W4379600250 cites W3025494488 @default.
- W4379600250 cites W3045656684 @default.
- W4379600250 cites W3083406432 @default.
- W4379600250 cites W3111646026 @default.
- W4379600250 cites W3130597069 @default.
- W4379600250 cites W3158172244 @default.
- W4379600250 cites W3170668554 @default.
- W4379600250 cites W3172313906 @default.
- W4379600250 cites W3177828909 @default.
- W4379600250 cites W3188186333 @default.
- W4379600250 cites W3190126839 @default.
- W4379600250 cites W3200778883 @default.
- W4379600250 cites W4210842751 @default.
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- W4379600250 doi "https://doi.org/10.1093/molbev/msad134" @default.
- W4379600250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37279941" @default.
- W4379600250 hasPublicationYear "2023" @default.
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