Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379600627> ?p ?o ?g. }
- W4379600627 endingPage "1749" @default.
- W4379600627 startingPage "1731" @default.
- W4379600627 abstract "In the 5th edition of the WHO CNS tumor classification (CNS5, 2021), multiple molecular characteristics became essential diagnostic criteria for many additional CNS tumor types. For those tumors, an integrated, histomolecular diagnosis is required. A variety of approaches exists for determining the status of the underlying molecular markers. The present guideline focuses on the methods that can be used for assessment of the currently most informative diagnostic and prognostic molecular markers for the diagnosis of gliomas, glioneuronal and neuronal tumors. The main characteristics of the molecular methods are systematically discussed, followed by recommendations and information on available evidence levels for diagnostic measures. The recommendations cover DNA and RNA next-generation-sequencing, methylome profiling, and select assays for single/limited target analyses, including immunohistochemistry. Additionally, because of its importance as a predictive marker in IDH-wildtype glioblastomas, tools for the analysis of MGMT promoter methylation status are covered. A structured overview of the different assays with their characteristics, especially their advantages and limitations, is provided, and requirements for input material and reporting of results are clarified. General aspects of molecular diagnostic testing regarding clinical relevance, accessibility, cost, implementation, regulatory, and ethical aspects are discussed as well. Finally, we provide an outlook on new developments in the landscape of molecular testing technologies in neuro-oncology." @default.
- W4379600627 created "2023-06-08" @default.
- W4379600627 creator A5000418022 @default.
- W4379600627 creator A5005354758 @default.
- W4379600627 creator A5010891460 @default.
- W4379600627 creator A5014129073 @default.
- W4379600627 creator A5022651335 @default.
- W4379600627 creator A5023573690 @default.
- W4379600627 creator A5026984802 @default.
- W4379600627 creator A5029877122 @default.
- W4379600627 creator A5030825777 @default.
- W4379600627 creator A5039647180 @default.
- W4379600627 creator A5048627921 @default.
- W4379600627 creator A5050961926 @default.
- W4379600627 creator A5057141936 @default.
- W4379600627 creator A5063978061 @default.
- W4379600627 creator A5080482957 @default.
- W4379600627 creator A5081249010 @default.
- W4379600627 creator A5089427177 @default.
- W4379600627 date "2023-06-02" @default.
- W4379600627 modified "2023-10-13" @default.
- W4379600627 title "Molecular diagnostic tools for the World Health Organization (WHO) 2021 classification of gliomas, glioneuronal and neuronal tumors; an EANO guideline" @default.
- W4379600627 cites W1876545041 @default.
- W4379600627 cites W1949037014 @default.
- W4379600627 cites W1965705450 @default.
- W4379600627 cites W2005036868 @default.
- W4379600627 cites W2011204207 @default.
- W4379600627 cites W2028785929 @default.
- W4379600627 cites W2040656207 @default.
- W4379600627 cites W2046029490 @default.
- W4379600627 cites W2046796218 @default.
- W4379600627 cites W2050345568 @default.
- W4379600627 cites W2056272826 @default.
- W4379600627 cites W2081253472 @default.
- W4379600627 cites W2096118113 @default.
- W4379600627 cites W2105100844 @default.
- W4379600627 cites W2106816824 @default.
- W4379600627 cites W2112567075 @default.
- W4379600627 cites W2137868544 @default.
- W4379600627 cites W2138270253 @default.
- W4379600627 cites W2140028316 @default.
- W4379600627 cites W2169438753 @default.
- W4379600627 cites W2171418517 @default.
- W4379600627 cites W2207035666 @default.
- W4379600627 cites W2267983237 @default.
- W4379600627 cites W2278061057 @default.
- W4379600627 cites W2282164829 @default.
- W4379600627 cites W2286322195 @default.
- W4379600627 cites W2328946792 @default.
- W4379600627 cites W2338116242 @default.
- W4379600627 cites W2516799566 @default.
- W4379600627 cites W2532037152 @default.
- W4379600627 cites W2553451383 @default.
- W4379600627 cites W2581179619 @default.
- W4379600627 cites W2618958001 @default.
- W4379600627 cites W2626440326 @default.
- W4379600627 cites W2743802042 @default.
- W4379600627 cites W2749025438 @default.
- W4379600627 cites W2751670136 @default.
- W4379600627 cites W2764013069 @default.
- W4379600627 cites W2787816121 @default.
- W4379600627 cites W2804202266 @default.
- W4379600627 cites W2811036728 @default.
- W4379600627 cites W2893054481 @default.
- W4379600627 cites W2894158895 @default.
- W4379600627 cites W2900953219 @default.
- W4379600627 cites W2903049418 @default.
- W4379600627 cites W2909924790 @default.
- W4379600627 cites W2910801868 @default.
- W4379600627 cites W2912837862 @default.
- W4379600627 cites W2914942635 @default.
- W4379600627 cites W2922989408 @default.
- W4379600627 cites W2923956523 @default.
- W4379600627 cites W2946676363 @default.
- W4379600627 cites W2953648775 @default.
- W4379600627 cites W2969002050 @default.
- W4379600627 cites W2973085389 @default.
- W4379600627 cites W2977248142 @default.
- W4379600627 cites W2980759299 @default.
- W4379600627 cites W2983799945 @default.
- W4379600627 cites W2991130272 @default.
- W4379600627 cites W2995638885 @default.
- W4379600627 cites W3006662217 @default.
- W4379600627 cites W3008367733 @default.
- W4379600627 cites W3014398723 @default.
- W4379600627 cites W3020099303 @default.
- W4379600627 cites W3034266209 @default.
- W4379600627 cites W3034286858 @default.
- W4379600627 cites W3036877126 @default.
- W4379600627 cites W3045101210 @default.
- W4379600627 cites W3082278712 @default.
- W4379600627 cites W3092226128 @default.
- W4379600627 cites W3097339274 @default.
- W4379600627 cites W3100209659 @default.
- W4379600627 cites W3107056755 @default.
- W4379600627 cites W3110787789 @default.
- W4379600627 cites W3117079035 @default.
- W4379600627 cites W3122927608 @default.