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- W4379619504 abstract "SUMMARY Somatic cells of human males and females have 45 chromosomes in common, including the “active” X chromosome. In males the 46 th chromosome is a Y; in females it is an “inactive” X (Xi). Through linear modeling of autosomal gene expression in cells from individuals with zero to three Xi and zero to four Y chromosomes, we found that Xi and Y impact autosomal expression broadly and with remarkably similar effects. Studying sex-chromosome structural anomalies, promoters of Xi- and Y-responsive genes, and CRISPR inhibition, we traced part of this shared effect to homologous transcription factors – ZFX and ZFY – encoded by Chr X and Y. This demonstrates sex-shared mechanisms by which Xi and Y modulate autosomal expression. Combined with earlier analyses of sex-linked gene expression, our studies show that 21% of all genes expressed in lymphoblastoid cells or fibroblasts change expression significantly in response to Xi or Y chromosomes." @default.
- W4379619504 created "2023-06-08" @default.
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- W4379619504 date "2023-06-07" @default.
- W4379619504 modified "2023-10-03" @default.
- W4379619504 title "The human Y and inactive X chromosomes similarly modulate autosomal gene expression" @default.
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