Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379645522> ?p ?o ?g. }
- W4379645522 abstract "Some types of collagens, including transmembrane MACIT collagens and C. elegans cuticle collagens, are N-terminally cleaved at a dibasic site that resembles the consensus for furin or other proprotein convertases of the subtilisin/kexin (PCSK) family. Such cleavage may release transmembrane collagens from the plasma membrane and affect extracellular matrix assembly or structure. However, the functional consequences of such cleavage are unclear and evidence for the role of specific PCSKs is lacking. Here, we used endogenous collagen fusions to fluorescent proteins to visualize the secretion and assembly of the first collagen-based cuticle in C. elegans and then tested the role of the PCSK BLI-4 in these processes. Unexpectedly, we found that cuticle collagens SQT-3 and DPY-17 are secreted into the extraembryonic space several hours before cuticle matrix assembly. Furthermore, this early secretion depends on BLI-4/PCSK; in bli-4 and cleavage-site mutants, SQT-3 and DPY-17 are not efficiently secreted and instead form large intracellular aggregates. Their later assembly into cuticle matrix is reduced but not entirely blocked. These data reveal a role for collagen N-terminal processing in intracellular trafficking and in the spatial and temporal restriction of matrix assembly in vivo . Our observations also prompt a revision of the classic model for C. elegans cuticle matrix assembly and the pre-cuticle-to-cuticle transition, suggesting that cuticle layer assembly proceeds via a series of regulated steps and not simply by sequential secretion and deposition." @default.
- W4379645522 created "2023-06-08" @default.
- W4379645522 creator A5011154468 @default.
- W4379645522 creator A5012114487 @default.
- W4379645522 creator A5041470900 @default.
- W4379645522 creator A5054537895 @default.
- W4379645522 creator A5070787487 @default.
- W4379645522 creator A5075572246 @default.
- W4379645522 creator A5078327150 @default.
- W4379645522 date "2023-06-07" @default.
- W4379645522 modified "2023-10-03" @default.
- W4379645522 title "The proprotein convertase BLI-4 promotes collagen secretion during assembly of the<i>Caenorhabditis elegans</i>cuticle" @default.
- W4379645522 cites W1595269103 @default.
- W4379645522 cites W1641205561 @default.
- W4379645522 cites W1832041654 @default.
- W4379645522 cites W1944127002 @default.
- W4379645522 cites W1980179012 @default.
- W4379645522 cites W1989952069 @default.
- W4379645522 cites W1990300902 @default.
- W4379645522 cites W1994644114 @default.
- W4379645522 cites W1999224742 @default.
- W4379645522 cites W2000646355 @default.
- W4379645522 cites W2002750189 @default.
- W4379645522 cites W2005878155 @default.
- W4379645522 cites W2015468345 @default.
- W4379645522 cites W2018301249 @default.
- W4379645522 cites W2022195195 @default.
- W4379645522 cites W2025442574 @default.
- W4379645522 cites W2027916610 @default.
- W4379645522 cites W2029212512 @default.
- W4379645522 cites W2032435199 @default.
- W4379645522 cites W2033034806 @default.
- W4379645522 cites W2041349540 @default.
- W4379645522 cites W2042567314 @default.
- W4379645522 cites W2043324515 @default.
- W4379645522 cites W2045015262 @default.
- W4379645522 cites W2046153876 @default.
- W4379645522 cites W2047524138 @default.
- W4379645522 cites W2064722086 @default.
- W4379645522 cites W2072153468 @default.
- W4379645522 cites W2081172215 @default.
- W4379645522 cites W2082924324 @default.
- W4379645522 cites W2083207344 @default.
- W4379645522 cites W2083624688 @default.
- W4379645522 cites W2085239838 @default.
- W4379645522 cites W2085368314 @default.
- W4379645522 cites W2087701580 @default.
- W4379645522 cites W2094222285 @default.
- W4379645522 cites W2096647918 @default.
- W4379645522 cites W2098358795 @default.
- W4379645522 cites W2102089623 @default.
- W4379645522 cites W2103336842 @default.
- W4379645522 cites W2124492445 @default.
- W4379645522 cites W2135456971 @default.
- W4379645522 cites W2136261717 @default.
- W4379645522 cites W2147515706 @default.
- W4379645522 cites W2148743985 @default.
- W4379645522 cites W2164235861 @default.
- W4379645522 cites W2166179062 @default.
- W4379645522 cites W2166815562 @default.
- W4379645522 cites W2167279371 @default.
- W4379645522 cites W2335085428 @default.
- W4379645522 cites W2492994488 @default.
- W4379645522 cites W2614518491 @default.
- W4379645522 cites W2614984130 @default.
- W4379645522 cites W2616612296 @default.
- W4379645522 cites W2747545374 @default.
- W4379645522 cites W2750370132 @default.
- W4379645522 cites W2800846715 @default.
- W4379645522 cites W2891018818 @default.
- W4379645522 cites W2899623746 @default.
- W4379645522 cites W2922856627 @default.
- W4379645522 cites W2972184354 @default.
- W4379645522 cites W2987537097 @default.
- W4379645522 cites W3005874143 @default.
- W4379645522 cites W3008997748 @default.
- W4379645522 cites W3043655827 @default.
- W4379645522 cites W306302075 @default.
- W4379645522 cites W3087920740 @default.
- W4379645522 cites W3091884798 @default.
- W4379645522 cites W3094824097 @default.
- W4379645522 cites W3123134526 @default.
- W4379645522 cites W3126240036 @default.
- W4379645522 cites W3133357318 @default.
- W4379645522 cites W3159547958 @default.
- W4379645522 cites W3178191813 @default.
- W4379645522 cites W3180956051 @default.
- W4379645522 cites W4206105445 @default.
- W4379645522 cites W4213253179 @default.
- W4379645522 cites W4243859336 @default.
- W4379645522 cites W4282946166 @default.
- W4379645522 cites W4290852271 @default.
- W4379645522 cites W4319333784 @default.
- W4379645522 doi "https://doi.org/10.1101/2023.06.06.542650" @default.
- W4379645522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37333289" @default.
- W4379645522 hasPublicationYear "2023" @default.
- W4379645522 type Work @default.
- W4379645522 citedByCount "0" @default.
- W4379645522 crossrefType "posted-content" @default.
- W4379645522 hasAuthorship W4379645522A5011154468 @default.