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• W4379647584 abstract "Background Micronutrient deficiency (MND) is common among patients with certain chronic inflammatory diseases. MND is associated with a pro-inflammatory status and co-morbidities. Recent evidence documented a relevant prevalence of MND in Spondyloarthritis (SpA) and its interplay with gender and inflammatory-dependent dysmetabolism [1] . MND in patients with Enteropathic Spondyloarthritis (ESpA) has not been analyzed even though the concomitant occurrence of Inflammatory Bowel Disease (IBD) and SpA might strongly impact MNDs. Objectives In this study, we aimed at comparing for the first time the occurrence of anemia and deficiencies of ferritin (Fe), vitamin B12 (B12), folic acid (FA), and vitamin D [25(OH)D] in patients with ESpA, IBD without SpA, and isolated SpA. Methods In a prospective case-control study, consecutive subjects were enrolled among ESpA (Cases), IBD (Controls-1), and SpA (Controls-2) patients referring to combined gastro-rheumatologic outpatient Clinic at the “Tor Vergata” University Hospital (Rome, Italy). Each Case (ESpA) was retrospectively matched (1:1) for IBD type with one IBD subject from Controls-1 group. Inclusion criteria: 1) age ≥18 years; 2) follow up (≥2 visits/year); 3) recent (<3 mos) micronutrients data. Additional inclusion criteria for Cases: 1) diagnosis of SpA, 2) diagnosis of IBD. Additional inclusion criteria: 1) for Controls-1: diagnosis of IBD; 2) for Controls-2: diagnosis of SpA. Additional exclusion criteria: 1) for Controls-1: diagnosis of SpA; 2) for Controls-2: diagnosis of IBD. Mean and standard deviation (SD) express normally distributed variables; for non-symmetric distributed data, median and range were used. Continuous variables were compared by using either unpaired T test or the Mann-Whitney U test, as appropriate. Categorical variables were were compared using the Chi-squared test or Fisher’s exact test, as appropriate. P value<0.05 was significant. Results One hundred ESpA (Cases) were enrolled and matched with 100 IBD (Controls-1, n=58 Crohn’s Disease - CD, n=42 Ulcerative Colitis - UC), and 100 SpA including 81% psoriatic-SpA (Controls-2). The median age was comparable between groups (Cases, 50 [20-77]; Controls-1; 48.5 [19-86], Controls-2; 53 [26-77]), while male gender was more frequent in Controls-1 than Cases (P=0.0001). The median IBD duration was shorter in Cases than in Controls-1 (P<0.0001) while the frequency of IBD-related surgery was comparable between the two groups. In patients with CD (n=58 in both groups), lesions distribution was comparable between Cases and Controls-1; differently, penetrating CD was less frequent in Cases vs Controls-1 (P=0.02). Cases had a shorter SpA disease duration (P=0.004) and a higher rate of patients in moderate/high SpA disease activity than Controls-2 (P=0.02). Anemia (Hb≤12 g/dl) was slightly prevalent in Cases and Controls-1 (15% and 19%, respectively) than in Controls-2 (7%) while Fe deficiency (Fe≤15 ng/dL) was similar between Cases and Controls-1 and significantly prevalent in both Cases and Controls-1 than Controls-2 (P=0.001 for both). The B12 deficiency (≤200 pmol/l) was similar between Cases and Controls-1 but it resulted more frequent in Controls-1 than Controls-2 (P=0.04). The rate of folate defect (≤4 ng/ml) was similar between Cases and Controls-1 but it resulted less frequent in Controls-2 than in both Cases (P=0.002) and Controls-1 (P=0.00001). The 25(OH)D deficiency (≤20 ng/ml) was more frequent in Controls-2 than Cases (P=0.02). Conclusion In ESpA, MND results relevant and appears comparable with MND revealed in IBD patients without SpA. The isolated SpA seems to be related mainly with vitamin D deficiency that in turn might be linked to SpA disease duration and activity. Reference [1]Triggianese P, et al. Micronutrients deficiencies in patients with spondylarthritis: the potential immunometabolic crosstalk in disease phenotype. Eur Rev Med Pharmacol 2022;26:2025-2035. Acknowledgements: NIL. Disclosure of Interests None Declared." @default.
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• W4379647584 date "2023-05-30" @default.
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• W4379647584 title "AB1071 MICRONUTRIENTS DEFICIENCY IN ENTEROPATHIC SPONDYLOARTHRITIS: EXPLORING THE INTERPLAY BETWEEN JOINT AND GUT DISEASES IN A CASE-CONTROL STUDY" @default.
• W4379647584 doi "https://doi.org/10.1136/annrheumdis-2023-eular.4895" @default.
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