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- W4379650605 abstract "<h3>Background</h3> Bone lymphoma is rare disease, its diagnosis is usually delayed due to the unspecefic clinical and radiological signs. <h3>Objectives</h3> Our objective was to describe the clinical, biological and radiological aspects of bone lymphoma to optimize diagnostic approaches. <h3>Methods</h3> 14 cases of bone lymphoma were collected in the Rheumatology Department of Sousse between 2001 and 2022. <h3>Results</h3> The mean age was 42 with a sex ratio of 1. The main symptom in 14 patients was pain associated with deterioration of general condition (10 cases), swelling of lymph glands (8 cases), fever and night sweats (6 cases), neurological signs (6 cases) with a diagnostic delay of 4 months. In biology, 13 patients had biological inflammatory syndrome, 2 of the 14 patients had hypercalcemia with a mean of 2.85, 6 patients had elevated LDH and 6 had elevated PAL. The abnormalities of the CBC were anemia in 10 cases, leukopenia in 1 case, hyperleukocytosis in 6 cases. On imaging, the lesions were single in 6 cases and multiple in 8 cases. A lytic process was found in 9 cases, osteocondensation in 3 cases and mixed lesions in 2 cases. Cortical rupture was noted in 3 cases. The soft tissues were infiltrated in 8 cases. The sites were vertebral (8 cases), sacrum (2 cases), iliac (1 case), long bone (3 cases). MRI showed a T1 hypo signal and T2 hyper signal in all cases, bone scintigraphy was performed in 6 patients and showed hyperfixation in 5 cases and a heterogeneous aspect in 1 case. A bone or lymph node biopsy was performed in all 14 patients, confirming the diagnosis and showing Hodgkin’s lymphoma in 6 cases and non-Hodgkin’s lymphoma in 8 cases, 7 of which were diffuse large-cell B lymphomas. <h3>Conclusion</h3> Due to the rarity and the various clinical and radiological presentations of bone lymphoma, the diagnosis may be difficult which is why the biopsy so important. <h3>REFERENCES:</h3> NIL. <h3>Acknowledgements:</h3> NIL. <h3>Disclosure of Interests</h3> None Declared." @default.
- W4379650605 created "2023-06-08" @default.
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- W4379650605 date "2023-05-30" @default.
- W4379650605 modified "2023-10-10" @default.
- W4379650605 title "AB1498 MANIFESTATIONS OF BONE LYMPHOMA IN A RHEUMATOLOGY DEPARTMENT" @default.
- W4379650605 doi "https://doi.org/10.1136/annrheumdis-2023-eular.6443" @default.
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