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- W4379653446 abstract "Accurate regulation of centrosome size is essential for ensuring error-free cell division, and dysregulation of centrosome size has been linked to various pathologies, including developmental defects and cancer. While a universally accepted model for centrosome size regulation is lacking, prior theoretical and experimental work suggest a centrosome growth model involving autocatalytic assembly of the pericentriolic material. Here we show that the autocatalytic assembly model fails to explain the attainment of equal centrosome sizes, which is crucial for error-free cell division. Incorporating latest experimental findings into the molecular mechanisms governing centrosome assembly, we introduce a new quantitative theory for centrosome growth involving catalytic assembly within a shared pool of enzymes. Our model successfully achieves robust size equality between maturing centrosome pairs, mirroring cooperative growth dynamics observed in experiments. To validate our theoretical predictions, we compare them with available experimental data and demonstrate the broad applicability of the catalytic growth model across different organisms, which exhibit distinct growth dynamics and size scaling characteristics." @default.
- W4379653446 created "2023-06-08" @default.
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- W4379653446 date "2023-06-07" @default.
- W4379653446 modified "2023-09-26" @default.
- W4379653446 title "Catalytic growth in a shared enzyme pool ensures robust control of centrosome size" @default.
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- W4379653446 doi "https://doi.org/10.1101/2023.06.06.543875" @default.
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