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- W4379662399 abstract "Objective: To assess whether the expression of oncoproteins, p53, bcl-2 and fas, correlated with the clinical and pathological parameters. in squamous celi laryngeal carcinoma (SCLC). Study design: Medical records of 30 patients who were operated for SCLC, were reviewed, and histopathological and immunhistochemical assessments of the corresponding tissue samples were performed. Methods: The monoclonal antibodies to p53 bcl-2 and fas proteins were used for immunhistochemical staining. Streptavidin-Biotin, horseradish method was used. The data obtained was compared with the clinical and histopathological results. Results: A positive staining for p53 was obtained in 19 (63.3% ) of 30 tumors. Only one (3.3%) of 30 tumors positively stained for bcl-2. A positive staining for fas was obtained in 27 (90%) of the tumors. The results of p53 and bcl-2 did not correlate with mitotic count (MC), grade, T and N, and smoking. There was a correlation between fas and MC (p=0.007). But, the results of fas did not correlate with grade, T, N and smoking. A correlation was not found between; p53 vs.bcl-2 (p<0.05); p53 vs. fas (p<0.05); and bcl-2 vs. fas (p<0.05). Conclusion: There was no association between the oncoproteins (p53, bcl-2 and fas) and clinical or pathological parameters studied. The expression of the oncoproteins between smokers and non smokers did not show signifıcant difference as well." @default.
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- W4379662399 date "2001-01-01" @default.
- W4379662399 modified "2023-10-15" @default.
- W4379662399 title "Significance of p53, bcl-2 and Fas oncogenes in the Iaryngeal squamous celi carcinoma" @default.
- W4379662399 doi "https://doi.org/10.58600/eurjther.2001-12-1-1421-arch" @default.
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