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- W4379740272 abstract "Peritoneal metastases from colorectal cancer have a dismal natural history and poor response to systemic chemotherapy. Cytoreductive surgery, the mainstay of locoregional control of peritoneal carcinomatosis, with hyperthermic intraperitoneal chemotherapy (HIPEC) has shown survival benefit in selected patients. While recent studies such as the PRODIGE 7 trial have not demonstrated added benefit of HIPEC, these trials have limitations (i.e. choice of HIPEC agent, patient population), and more studies are needed. The efficacy of prophylactic HIPEC in patients at high risk for peritoneal recurrence remains controversial. Ongoing trials, including intraperitoneal delivery of novel anti-cancer agents, may yield significant new therapeutic options." @default.
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- W4379740272 date "2023-09-01" @default.
- W4379740272 modified "2023-09-26" @default.
- W4379740272 title "Evolving role of cytoreduction and HIPEC for colorectal cancer" @default.
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- W4379740272 doi "https://doi.org/10.1016/j.scrs.2023.100970" @default.
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