Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379740282> ?p ?o ?g. }
- W4379740282 abstract "Abstract Rhesus macaques ( Macaca mulatta , RMs) are widely used in sexual maturation studies due to their high genetic and physiological similarity to humans. However, judging sexual maturity in captive RMs based on blood physiological indicators, female menstruation, and male ejaculation behavior can be inaccurate. Here, we explored changes in RMs before and after sexual maturation based on multi-omics analysis and identified markers for determining sexual maturity. We found that differentially expressed microbiota, metabolites, and genes before and after sexual maturation showed many potential correlations. Specifically, genes involved in spermatogenesis ( TSSK2 , HSP90AA1 , S OX5 , SPAG16 , and SPATC1 ) were up-regulated in male macaques, and significant changes in gene ( CD36 ), metabolites (cholesterol, 7-ketolithocholic acid, and 12-ketolithocholic acid), and microbiota ( Lactobacillus ) related to cholesterol metabolism were also found, suggesting the sexually mature males have stronger sperm fertility and cholesterol metabolism compared to sexually immature males. In female macaques, most differences before and after sexual maturity were related to tryptophan metabolism, including changes in IDO1 , IDO2 , IFNGR2 , IL1Β , IL10 , L-tryptophan, kynurenic acid (KA), indole-3-acetic acid (IAA), indoleacetaldehyde, and Bifidobacteria , indicating that sexually mature females exhibit stronger neuromodulation and intestinal immunity than sexually immature females. Cholesterol metabolism-related changes ( CD36 , 7-ketolithocholic acid, 12-ketolithocholic acid) were also observed in female and male macaques. Exploring differences before and after sexual maturation through multi-omics, we identified potential biomarkers of sexual maturity in RMs, including Lactobacillus (for males) and Bifidobacterium (for females) valuable for RM breeding and sexual maturation research." @default.
- W4379740282 created "2023-06-08" @default.
- W4379740282 creator A5004347770 @default.
- W4379740282 creator A5009613920 @default.
- W4379740282 creator A5011084958 @default.
- W4379740282 creator A5012354716 @default.
- W4379740282 creator A5021761232 @default.
- W4379740282 creator A5036381691 @default.
- W4379740282 creator A5045407304 @default.
- W4379740282 creator A5046364421 @default.
- W4379740282 creator A5073019640 @default.
- W4379740282 creator A5079534445 @default.
- W4379740282 creator A5089285750 @default.
- W4379740282 date "2023-06-07" @default.
- W4379740282 modified "2023-10-18" @default.
- W4379740282 title "Multi-omics analysis reveals changes in tryptophan and cholesterol metabolism before and after sexual maturation in captive macaques" @default.
- W4379740282 cites W1487436709 @default.
- W4379740282 cites W1519089655 @default.
- W4379740282 cites W1525223236 @default.
- W4379740282 cites W1869537815 @default.
- W4379740282 cites W1887681162 @default.
- W4379740282 cites W1902399643 @default.
- W4379740282 cites W1923423561 @default.
- W4379740282 cites W1968458420 @default.
- W4379740282 cites W1971908589 @default.
- W4379740282 cites W1972237932 @default.
- W4379740282 cites W1974186916 @default.
- W4379740282 cites W2011888952 @default.
- W4379740282 cites W2012222938 @default.
- W4379740282 cites W2035779227 @default.
- W4379740282 cites W2037974607 @default.
- W4379740282 cites W2040695463 @default.
- W4379740282 cites W2043040454 @default.
- W4379740282 cites W2044216294 @default.
- W4379740282 cites W2045204781 @default.
- W4379740282 cites W2046422565 @default.
- W4379740282 cites W2057715430 @default.
- W4379740282 cites W2067256607 @default.
- W4379740282 cites W2071537273 @default.
- W4379740282 cites W2074639016 @default.
- W4379740282 cites W2078953012 @default.
- W4379740282 cites W2079919032 @default.
- W4379740282 cites W2091015159 @default.
- W4379740282 cites W2091755990 @default.
- W4379740282 cites W2092450200 @default.
- W4379740282 cites W2092787182 @default.
- W4379740282 cites W2094544572 @default.
- W4379740282 cites W2094927486 @default.
- W4379740282 cites W2095195313 @default.
- W4379740282 cites W2102278945 @default.
- W4379740282 cites W2103237567 @default.
- W4379740282 cites W2112501735 @default.
- W4379740282 cites W2120077307 @default.
- W4379740282 cites W2122559203 @default.
- W4379740282 cites W2133856765 @default.
- W4379740282 cites W2140685276 @default.
- W4379740282 cites W2143485490 @default.
- W4379740282 cites W2149905790 @default.
- W4379740282 cites W2151255529 @default.
- W4379740282 cites W2153536110 @default.
- W4379740282 cites W2159482845 @default.
- W4379740282 cites W2159954944 @default.
- W4379740282 cites W2160984153 @default.
- W4379740282 cites W2164685446 @default.
- W4379740282 cites W2170747616 @default.
- W4379740282 cites W2179438025 @default.
- W4379740282 cites W2222423398 @default.
- W4379740282 cites W2281609143 @default.
- W4379740282 cites W2331277810 @default.
- W4379740282 cites W2334494022 @default.
- W4379740282 cites W2428595929 @default.
- W4379740282 cites W2578182640 @default.
- W4379740282 cites W2580550886 @default.
- W4379740282 cites W2626912469 @default.
- W4379740282 cites W2806149007 @default.
- W4379740282 cites W2807927929 @default.
- W4379740282 cites W2861370805 @default.
- W4379740282 cites W2897611961 @default.
- W4379740282 cites W2913092010 @default.
- W4379740282 cites W2914348147 @default.
- W4379740282 cites W2925236070 @default.
- W4379740282 cites W2937873671 @default.
- W4379740282 cites W2944545583 @default.
- W4379740282 cites W2963276645 @default.
- W4379740282 cites W2969718750 @default.
- W4379740282 cites W2972269795 @default.
- W4379740282 cites W2983472107 @default.
- W4379740282 cites W2995647484 @default.
- W4379740282 cites W3014061803 @default.
- W4379740282 cites W3023425769 @default.
- W4379740282 cites W3026138206 @default.
- W4379740282 cites W3035554070 @default.
- W4379740282 cites W3046959387 @default.
- W4379740282 cites W3047606396 @default.
- W4379740282 cites W3048226838 @default.
- W4379740282 cites W3094053778 @default.
- W4379740282 cites W3127642212 @default.
- W4379740282 cites W3177299330 @default.
- W4379740282 cites W3204281013 @default.
- W4379740282 cites W3215499858 @default.