Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379741518> ?p ?o ?g. }
- W4379741518 endingPage "166762" @default.
- W4379741518 startingPage "166762" @default.
- W4379741518 abstract "Decidualization is a critical process for successful pregnancy. Disorders in this process are tightly associated with adverse pregnancy outcomes including spontaneous abortion. However, the potential molecular mechanisms of lncRNAs underlying this process are yet to be fully elucidated. In this study, we utilized RNA sequencing (RNA-seq) to identify differentially expressed lncRNAs during endometrial decidualization with a pregnant mouse model. Based on RNA-seq analysis, weighted gene co-expression network analysis (WGCNA) was performed to construct the lncRNA-mRNA co-expression network and to identify decidualization-associated hub lncRNAs. Through comprehensive screening and validation, we identified a novel lncRNA, RP24-315D19.10 and studied its function in primary mouse endometrial stromal cells (mESCs). lncRNA RP24-315D19.10 was highly expressed during decidualization. Knockdown of RP24-315D19.10 significantly inhibited mESCs decidualization in vitro. Mechanistically, RNA pull-down and RNA immunoprecipitation assays indicated that cytoplasmic RP24-315D19.10 could bind to hnRNPA2B1, thereby upregulating hnRNPA2B1 expression. Site-directed mutagenesis followed by biolayer interferometry analysis additionally illustrated that hnRNPA2B1 protein specifically bound to the ~-142ccccc~-167 region of the RP24-315D19.10 sequence. hnRPA2B1 deficiency impairs mESCs decidualization in vitro and we found that the inhibition in decidualization caused by RP24-315D19.10 knockdown was rescued by hnRNPA2B1 overexpression. Moreover, the expression of hnRNPA2B1 in spontaneous abortion women with deficient decidualization was significantly lower than that in healthy individuals, suggesting that hnRNPA2B1 may be involved in the development and progression of spontaneous abortion caused by decidualization failure. Collectively, our study indicates RP24-315D19.10 is a critical regulator for endometrial decidualization and RP24-315D19.10-regulated hnRNPA2B1 might be a new mark of decidualization-related spontaneous abortion." @default.
- W4379741518 created "2023-06-08" @default.
- W4379741518 creator A5005004006 @default.
- W4379741518 creator A5006544399 @default.
- W4379741518 creator A5022498946 @default.
- W4379741518 creator A5040871507 @default.
- W4379741518 creator A5046332135 @default.
- W4379741518 creator A5054012489 @default.
- W4379741518 creator A5056014255 @default.
- W4379741518 creator A5060851233 @default.
- W4379741518 creator A5070898395 @default.
- W4379741518 creator A5078047179 @default.
- W4379741518 creator A5086664284 @default.
- W4379741518 date "2023-10-01" @default.
- W4379741518 modified "2023-09-27" @default.
- W4379741518 title "lincRNA RP24-315D19.10 promotes endometrial decidualization via upregulation of hnRNPA2B1" @default.
- W4379741518 cites W1759611159 @default.
- W4379741518 cites W1894777043 @default.
- W4379741518 cites W1966327575 @default.
- W4379741518 cites W1973070606 @default.
- W4379741518 cites W1990498979 @default.
- W4379741518 cites W1993866784 @default.
- W4379741518 cites W1994248538 @default.
- W4379741518 cites W1999306345 @default.
- W4379741518 cites W2005566944 @default.
- W4379741518 cites W2006494078 @default.
- W4379741518 cites W2024440558 @default.
- W4379741518 cites W2045461902 @default.
- W4379741518 cites W2051340861 @default.
- W4379741518 cites W2052734212 @default.
- W4379741518 cites W2058349658 @default.
- W4379741518 cites W2060705109 @default.
- W4379741518 cites W2062502437 @default.
- W4379741518 cites W2063700769 @default.
- W4379741518 cites W2068361384 @default.
- W4379741518 cites W2072506120 @default.
- W4379741518 cites W2086747507 @default.
- W4379741518 cites W2107277218 @default.
- W4379741518 cites W2112675387 @default.
- W4379741518 cites W2119975890 @default.
- W4379741518 cites W2126598648 @default.
- W4379741518 cites W2132522861 @default.
- W4379741518 cites W2153268494 @default.
- W4379741518 cites W2156880688 @default.
- W4379741518 cites W2159675211 @default.
- W4379741518 cites W2162547088 @default.
- W4379741518 cites W2232816331 @default.
- W4379741518 cites W2296470113 @default.
- W4379741518 cites W2423205648 @default.
- W4379741518 cites W2509738156 @default.
- W4379741518 cites W2546360008 @default.
- W4379741518 cites W2623755584 @default.
- W4379741518 cites W2754876366 @default.
- W4379741518 cites W2769011958 @default.
- W4379741518 cites W2784570320 @default.
- W4379741518 cites W2790986334 @default.
- W4379741518 cites W2799937252 @default.
- W4379741518 cites W2800032606 @default.
- W4379741518 cites W2883670905 @default.
- W4379741518 cites W2888706343 @default.
- W4379741518 cites W2902475755 @default.
- W4379741518 cites W2910914574 @default.
- W4379741518 cites W2915362329 @default.
- W4379741518 cites W2947698233 @default.
- W4379741518 cites W2971469357 @default.
- W4379741518 cites W2987932879 @default.
- W4379741518 cites W3011229833 @default.
- W4379741518 cites W3026704632 @default.
- W4379741518 cites W3033214241 @default.
- W4379741518 cites W3038070218 @default.
- W4379741518 cites W3049152128 @default.
- W4379741518 cites W3090463198 @default.
- W4379741518 cites W3092480200 @default.
- W4379741518 cites W3105002027 @default.
- W4379741518 cites W3115880421 @default.
- W4379741518 cites W3144861820 @default.
- W4379741518 cites W3156006725 @default.
- W4379741518 cites W3164382315 @default.
- W4379741518 cites W3165511426 @default.
- W4379741518 cites W4210481839 @default.
- W4379741518 doi "https://doi.org/10.1016/j.bbadis.2023.166762" @default.
- W4379741518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37295480" @default.
- W4379741518 hasPublicationYear "2023" @default.
- W4379741518 type Work @default.
- W4379741518 citedByCount "0" @default.
- W4379741518 crossrefType "journal-article" @default.
- W4379741518 hasAuthorship W4379741518A5005004006 @default.
- W4379741518 hasAuthorship W4379741518A5006544399 @default.
- W4379741518 hasAuthorship W4379741518A5022498946 @default.
- W4379741518 hasAuthorship W4379741518A5040871507 @default.
- W4379741518 hasAuthorship W4379741518A5046332135 @default.
- W4379741518 hasAuthorship W4379741518A5054012489 @default.
- W4379741518 hasAuthorship W4379741518A5056014255 @default.
- W4379741518 hasAuthorship W4379741518A5060851233 @default.
- W4379741518 hasAuthorship W4379741518A5070898395 @default.
- W4379741518 hasAuthorship W4379741518A5078047179 @default.
- W4379741518 hasAuthorship W4379741518A5086664284 @default.
- W4379741518 hasConcept C104317684 @default.