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• W4379742562 abstract "Abstract Objective To identify a convergent neuroanatomical substrate for novelty seeking (NS), a stable personality trait, which could serve as a therapeutic target for transcranial magnetic stimulation (TMS). Methods We analyzed two independent datasets (total n=136) in which the Temperament and Character Inventory (TCI) was used to document alterations across 7 stable personality traits before and after brain lesions surgically induced by glioma resection. Using lesion network mapping, we examined whether alterations in NS were causally associated with lesions to specific brain networks. We assessed for strength of replication across datasets and specificity against other personality traits. Results Lesion locations that are linked to NS map to a common brain with its largest cluster in the dorsal cingulate. This map was specific to NS relative to other personality traits and overlapped with prior published neuroimaging findings related to the term “novelty”. Utilizing a pre-computed connectome, we also derived a map highlighting potential targets for non-invasive brain stimulation that may alter this stable personality trait. Conclusions We derived and cross-validated a brain network that is functionally connected to lesions that are causally responsible for the stable personality trait “novelty seeking”. Lesions to this network were associated with changes in NS. This includes a superficial node within the dorsolateral prefrontal cortex that may serve as a promising TMS target to modulate or protect against abnormal NS." @default.
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• W4379742562 date "2023-06-07" @default.
• W4379742562 modified "2023-09-26" @default.
• W4379742562 title "Lesion network localization of a stable personality trait" @default.
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• W4379742562 doi "https://doi.org/10.1101/2023.06.05.543261" @default.
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