Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379769521> ?p ?o ?g. }
- W4379769521 abstract "Fluctuations in nutrient and biomass availability, often as a result of disease, impart metabolic challenges that must be overcome in order to sustain cell survival and promote proliferation. Cells adapt to these environmental changes and stresses by adjusting their metabolic networks through a series of regulatory mechanisms. Our understanding of these rewiring events has largely been focused on those genetic transformations that alter protein expression and the biochemical mechanisms that change protein behavior, such as post-translational modifications and metabolite-based allosteric modulators. Mounting evidence suggests that a class of proteome surveillance proteins called molecular chaperones also can influence metabolic processes. Here, we summarize several ways the Hsp90 and Hsp70 chaperone families act on human metabolic enzymes and their supramolecular assemblies to change enzymatic activities and metabolite flux. We further highlight how these chaperones can assist in the translocation and degradation of metabolic enzymes. Collectively, these studies provide a new view for how metabolic processes are regulated to meet cellular demand and inspire new avenues for therapeutic intervention." @default.
- W4379769521 created "2023-06-09" @default.
- W4379769521 creator A5044209569 @default.
- W4379769521 creator A5049689672 @default.
- W4379769521 date "2023-06-16" @default.
- W4379769521 modified "2023-09-24" @default.
- W4379769521 title "The Roles of Molecular Chaperones in Regulating Cell Metabolism" @default.
- W4379769521 cites W1487184433 @default.
- W4379769521 cites W1492419097 @default.
- W4379769521 cites W1498172398 @default.
- W4379769521 cites W1515469702 @default.
- W4379769521 cites W1538354139 @default.
- W4379769521 cites W1542947565 @default.
- W4379769521 cites W1559661072 @default.
- W4379769521 cites W1578283200 @default.
- W4379769521 cites W1605149529 @default.
- W4379769521 cites W1706150252 @default.
- W4379769521 cites W1847698873 @default.
- W4379769521 cites W1876591066 @default.
- W4379769521 cites W1964174822 @default.
- W4379769521 cites W1967960279 @default.
- W4379769521 cites W1968322176 @default.
- W4379769521 cites W1969848300 @default.
- W4379769521 cites W1970847499 @default.
- W4379769521 cites W1972121275 @default.
- W4379769521 cites W1975981956 @default.
- W4379769521 cites W1978319709 @default.
- W4379769521 cites W1984072871 @default.
- W4379769521 cites W1994823455 @default.
- W4379769521 cites W1995709866 @default.
- W4379769521 cites W1997718936 @default.
- W4379769521 cites W1999592577 @default.
- W4379769521 cites W2002364392 @default.
- W4379769521 cites W2002583208 @default.
- W4379769521 cites W2002869675 @default.
- W4379769521 cites W2004396698 @default.
- W4379769521 cites W2009545612 @default.
- W4379769521 cites W2013944211 @default.
- W4379769521 cites W2014058353 @default.
- W4379769521 cites W2015644600 @default.
- W4379769521 cites W2021968303 @default.
- W4379769521 cites W2022531767 @default.
- W4379769521 cites W2022964430 @default.
- W4379769521 cites W2024074032 @default.
- W4379769521 cites W2024390232 @default.
- W4379769521 cites W2026070183 @default.
- W4379769521 cites W2026097883 @default.
- W4379769521 cites W2027705428 @default.
- W4379769521 cites W2028135614 @default.
- W4379769521 cites W2028532536 @default.
- W4379769521 cites W2029862275 @default.
- W4379769521 cites W2030073559 @default.
- W4379769521 cites W2030858953 @default.
- W4379769521 cites W2032157282 @default.
- W4379769521 cites W2032376704 @default.
- W4379769521 cites W2032696550 @default.
- W4379769521 cites W2037156284 @default.
- W4379769521 cites W2037417750 @default.
- W4379769521 cites W2037597488 @default.
- W4379769521 cites W2038441129 @default.
- W4379769521 cites W2039340205 @default.
- W4379769521 cites W2039524314 @default.
- W4379769521 cites W2039558597 @default.
- W4379769521 cites W2042838776 @default.
- W4379769521 cites W2042840948 @default.
- W4379769521 cites W2043445883 @default.
- W4379769521 cites W2044621729 @default.
- W4379769521 cites W2047345328 @default.
- W4379769521 cites W2047812106 @default.
- W4379769521 cites W2055684980 @default.
- W4379769521 cites W2058279551 @default.
- W4379769521 cites W2059832194 @default.
- W4379769521 cites W2060708334 @default.
- W4379769521 cites W2061271609 @default.
- W4379769521 cites W2062149017 @default.
- W4379769521 cites W2067511286 @default.
- W4379769521 cites W2068231534 @default.
- W4379769521 cites W2074180938 @default.
- W4379769521 cites W2075110943 @default.
- W4379769521 cites W2077084538 @default.
- W4379769521 cites W2078021348 @default.
- W4379769521 cites W2078589754 @default.
- W4379769521 cites W2079905392 @default.
- W4379769521 cites W2080277761 @default.
- W4379769521 cites W2080553628 @default.
- W4379769521 cites W2081155723 @default.
- W4379769521 cites W2087864393 @default.
- W4379769521 cites W2089400513 @default.
- W4379769521 cites W2089551665 @default.
- W4379769521 cites W2093169681 @default.
- W4379769521 cites W2093985232 @default.
- W4379769521 cites W2094143445 @default.
- W4379769521 cites W2096237314 @default.
- W4379769521 cites W2096308078 @default.
- W4379769521 cites W2097094654 @default.
- W4379769521 cites W2097799342 @default.
- W4379769521 cites W2098902167 @default.
- W4379769521 cites W2102322990 @default.
- W4379769521 cites W2105288217 @default.
- W4379769521 cites W2107312266 @default.