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- W4379780328 endingPage "1691" @default.
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- W4379780328 abstract "Cardiometabolic disease comprises cardiovascular and metabolic dysfunction and underlies the leading causes of morbidity and mortality, both within the United States and worldwide. Commensal microbiota are implicated in the development of cardiometabolic disease. Evidence suggests that the microbiome is relatively variable during infancy and early childhood, becoming more fixed in later childhood and adulthood. Effects of microbiota, both during early development, and in later life, may induce changes in host metabolism that modulate risk mechanisms and predispose toward the development of cardiometabolic disease. In this review, we summarize the factors that influence gut microbiome composition and function during early life and explore how changes in microbiota and microbial metabolism influence host metabolism and cardiometabolic risk throughout life. We highlight limitations in current methodology and approaches and outline state-of-the-art advances, which are improving research and building toward refined diagnosis and treatment options in microbiome-targeted therapies." @default.
- W4379780328 created "2023-06-09" @default.
- W4379780328 creator A5030863196 @default.
- W4379780328 creator A5078392652 @default.
- W4379780328 date "2023-06-09" @default.
- W4379780328 modified "2023-09-23" @default.
- W4379780328 title "Gut Microbiota and Microbial Metabolism in Early Risk of Cardiometabolic Disease" @default.
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