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• W4379780669 abstract "Objective: To conduct analyzes of the peculiarities of left ventricular (LV) diastolic function in patients with hypertension disease with concomitant T2DM and without it before and after complex treatment with the inclusion of Eplerenone 50 mg per day and Trimetazidine 80 mg per day.Design and method: The study examined 25 patients with HT and DM in a subcompensated state, with an HbA1c level of 7.6±0.34% (main group) and 25 patients with HT stage II (HbA1c level of 5.01±0.13%), without T2DM aged 35 to 65 years, who were being treated at the clinic of the GI “L.T. Malaya Therapy National Institute of the NAMS of Ukraine”. The control group consisted of 20 healthy individuals (HbA1c level of 4.68±0.49%). Results: The data in Table 1 suggest that in patients with HT and HT with comorbid T2DM, the mean kinetics of diastolic flow of the fibrous ring was significantly lower in comparison with the control group. While the e`mean level in patients with T2DM and HT was significantly lower in comparison with patients with HT. Thus, the findings indicate that aggregate hemodynamic and metabolic alterations adversely affect the kinetic capabilities of the myocardium. Moreover, the lowest rates of the myocardial diastolic relaxation rate were probably found in patients with HT with T2DM. The latter proves that the comorbidity of these negative factors significantly reduces the functional capacity of the myocardium. Conclusions: The study of parameters of left ventricular diastolic function at the stage of myocardial functional disorders is necessary to prevent or reverse the development of heart failure in patients with comorbid pathology (HT with T2DM), which is the key to improving cardiovascular prognosis. A three-month treatment with Eplerenone and Trimetazidine in patients with HT with and without comorbid T2DM led to a decrease in the progression of heart failure and a reduction in cardiovascular risks. The study confirms the need for early prevention, timely diagnosis, and clarification of the development mechanisms of heart failure in patients with comorbid pathology." @default.
• W4379780669 created "2023-06-09" @default.
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• W4379780669 date "2023-06-01" @default.
• W4379780669 modified "2023-09-24" @default.
• W4379780669 title "PARAMETERS OF LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN PATIENTS WITH HYPERTENSION DISEASE WITH CONCOMITANT TYPE 2 DIABETES MELLITUS" @default.
• W4379780669 doi "https://doi.org/10.1097/01.hjh.0000940676.53809.48" @default.
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