Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379790664> ?p ?o ?g. }
- W4379790664 endingPage "11" @default.
- W4379790664 startingPage "1" @default.
- W4379790664 abstract "Vascular remodeling is a common pathological basis for cardiovascular diseases. Although both immune and non-immune cells have been suggested to contribute to this process, the complex cellular heterogeneity and intercellular interactions remain largely uncharacterized.In this study, we simulated early and late vascular remodeling by ligating the rat carotid artery for 1 week and 4 weeks, respectively. Using single-cell RNA-sequencing, we characterized gene expression signatures and driver signals of major cell types involved in vascular remodeling. Focused analysis revealed a novel sub-population of Selenbp1hi smooth muscle cells (SMCs) associated with vascular remodeling. Results of intercellular communication analyses predicted several ligand-receptor pairs between immune cells with SMCs and endothelial cells (ECs), implicating SMCs apoptosis and repair, ECs aging and inflammatory responses.We present a comprehensive single-cell atlas of vascular cells in early and late stages of ligated rat carotid artery, providing valuable insights into the understanding of the initiation and progression of vascular remodeling." @default.
- W4379790664 created "2023-06-09" @default.
- W4379790664 creator A5004725072 @default.
- W4379790664 creator A5012012613 @default.
- W4379790664 creator A5021738797 @default.
- W4379790664 creator A5035239238 @default.
- W4379790664 creator A5044726502 @default.
- W4379790664 creator A5044738030 @default.
- W4379790664 creator A5046179058 @default.
- W4379790664 creator A5047371223 @default.
- W4379790664 creator A5047724439 @default.
- W4379790664 creator A5063840506 @default.
- W4379790664 creator A5083061893 @default.
- W4379790664 date "2023-07-01" @default.
- W4379790664 modified "2023-10-12" @default.
- W4379790664 title "Single-cell RNA landscape of cell heterogeneity and immune microenvironment in ligation-induced vascular remodeling in rat" @default.
- W4379790664 cites W1987991415 @default.
- W4379790664 cites W2045579522 @default.
- W4379790664 cites W2090194051 @default.
- W4379790664 cites W2091309439 @default.
- W4379790664 cites W2102236245 @default.
- W4379790664 cites W2105078109 @default.
- W4379790664 cites W2123356744 @default.
- W4379790664 cites W2139842368 @default.
- W4379790664 cites W2142633227 @default.
- W4379790664 cites W2145836265 @default.
- W4379790664 cites W2147593845 @default.
- W4379790664 cites W2147915982 @default.
- W4379790664 cites W2159064660 @default.
- W4379790664 cites W2583663683 @default.
- W4379790664 cites W2758054633 @default.
- W4379790664 cites W2796172768 @default.
- W4379790664 cites W2890054451 @default.
- W4379790664 cites W2891644675 @default.
- W4379790664 cites W2910657916 @default.
- W4379790664 cites W2945834005 @default.
- W4379790664 cites W2948414306 @default.
- W4379790664 cites W2979167769 @default.
- W4379790664 cites W2982367920 @default.
- W4379790664 cites W2989921512 @default.
- W4379790664 cites W2998777569 @default.
- W4379790664 cites W3016157902 @default.
- W4379790664 cites W3016529146 @default.
- W4379790664 cites W3042705713 @default.
- W4379790664 cites W3043316039 @default.
- W4379790664 cites W3088819072 @default.
- W4379790664 cites W3089136059 @default.
- W4379790664 cites W3092107171 @default.
- W4379790664 cites W3103761932 @default.
- W4379790664 cites W3111554464 @default.
- W4379790664 cites W3121250726 @default.
- W4379790664 cites W3158558513 @default.
- W4379790664 cites W3165787945 @default.
- W4379790664 cites W3181183321 @default.
- W4379790664 cites W3185908984 @default.
- W4379790664 cites W3187663775 @default.
- W4379790664 cites W3195791299 @default.
- W4379790664 cites W4200534021 @default.
- W4379790664 cites W4210801992 @default.
- W4379790664 cites W4212872949 @default.
- W4379790664 cites W4224943355 @default.
- W4379790664 cites W4225370729 @default.
- W4379790664 cites W4226138105 @default.
- W4379790664 cites W4295249293 @default.
- W4379790664 cites W4319311607 @default.
- W4379790664 doi "https://doi.org/10.1016/j.atherosclerosis.2023.06.010" @default.
- W4379790664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37343431" @default.
- W4379790664 hasPublicationYear "2023" @default.
- W4379790664 type Work @default.
- W4379790664 citedByCount "0" @default.
- W4379790664 crossrefType "journal-article" @default.
- W4379790664 hasAuthorship W4379790664A5004725072 @default.
- W4379790664 hasAuthorship W4379790664A5012012613 @default.
- W4379790664 hasAuthorship W4379790664A5021738797 @default.
- W4379790664 hasAuthorship W4379790664A5035239238 @default.
- W4379790664 hasAuthorship W4379790664A5044726502 @default.
- W4379790664 hasAuthorship W4379790664A5044738030 @default.
- W4379790664 hasAuthorship W4379790664A5046179058 @default.
- W4379790664 hasAuthorship W4379790664A5047371223 @default.
- W4379790664 hasAuthorship W4379790664A5047724439 @default.
- W4379790664 hasAuthorship W4379790664A5063840506 @default.
- W4379790664 hasAuthorship W4379790664A5083061893 @default.
- W4379790664 hasConcept C134018914 @default.
- W4379790664 hasConcept C1491633281 @default.
- W4379790664 hasConcept C203014093 @default.
- W4379790664 hasConcept C2779395532 @default.
- W4379790664 hasConcept C2992686903 @default.
- W4379790664 hasConcept C54355233 @default.
- W4379790664 hasConcept C86803240 @default.
- W4379790664 hasConcept C8891405 @default.
- W4379790664 hasConcept C95444343 @default.
- W4379790664 hasConceptScore W4379790664C134018914 @default.
- W4379790664 hasConceptScore W4379790664C1491633281 @default.
- W4379790664 hasConceptScore W4379790664C203014093 @default.
- W4379790664 hasConceptScore W4379790664C2779395532 @default.
- W4379790664 hasConceptScore W4379790664C2992686903 @default.
- W4379790664 hasConceptScore W4379790664C54355233 @default.
- W4379790664 hasConceptScore W4379790664C86803240 @default.