Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379793104> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W4379793104 abstract "Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system characterized by simultaneous or consecutive episodes of acute optic neuritis and transverse myelitis. Attacks of NMOSD can result in the accrual of severe visual disability over time. This study aimed to develop and validate prognostic models for visual disability risk within 1, 3, and 5 years.Medical records of NMOSD patients were retrospectively analyzed. The least absolute shrinkage and selection operator (LASSO) regression algorithm and univariate and multivariate Cox regression analyses were performed to select predictors of visual disability. Two models predicting the probability of visual disability in 1, 3, and 5 years were developed based on different selections and displayed as nomograms. Risk scores were calculated for every patient, and a cut-off point was obtained to recognize patients at high risk.In total, 161 (25.2%) patients developed visual disabilities during the follow-up period. Four visual disability-related factors were selected using LASSO regression: optic neuritis (ON) onset, higher annual relapse rate (ARR) before maintenance therapy, no maintenance immune suppression therapy (IST), and initial severe attack. Three additional predictors were determined using multivariate Cox regression: male sex, age at first onset, and positive AQP4-IgG serology. Discrimination and calibration were satisfied, with concordance indexes (C-index) close to 0.9 in both models. Decision curve analysis showed good clinical usefulness in both models, and Kaplan-Meier curves showed satisfactory discrimination between patients with high risk and low risk by the cut-off points.This study reported predictors of visual disability and generated nomograms. High-risk patients need more active treatment and management to avoid unfavorable outcomes." @default.
- W4379793104 created "2023-06-09" @default.
- W4379793104 creator A5000801878 @default.
- W4379793104 creator A5002479149 @default.
- W4379793104 creator A5017755999 @default.
- W4379793104 creator A5022919112 @default.
- W4379793104 creator A5028702225 @default.
- W4379793104 creator A5041841487 @default.
- W4379793104 creator A5044870711 @default.
- W4379793104 date "2023-06-07" @default.
- W4379793104 modified "2023-09-26" @default.
- W4379793104 title "Visual disability in neuromyelitis optica spectrum disorders: prognostic prediction models" @default.
- W4379793104 cites W2037668591 @default.
- W4379793104 cites W2040615655 @default.
- W4379793104 cites W2091934359 @default.
- W4379793104 cites W2112165124 @default.
- W4379793104 cites W2114414511 @default.
- W4379793104 cites W2119862467 @default.
- W4379793104 cites W2120238028 @default.
- W4379793104 cites W2128597204 @default.
- W4379793104 cites W2129229339 @default.
- W4379793104 cites W2134211282 @default.
- W4379793104 cites W2135046866 @default.
- W4379793104 cites W2140047866 @default.
- W4379793104 cites W2293035635 @default.
- W4379793104 cites W2528222427 @default.
- W4379793104 cites W2752700429 @default.
- W4379793104 cites W2806973999 @default.
- W4379793104 cites W2898559532 @default.
- W4379793104 cites W2932668297 @default.
- W4379793104 cites W2935678420 @default.
- W4379793104 cites W3010147437 @default.
- W4379793104 cites W3122162424 @default.
- W4379793104 cites W3172333156 @default.
- W4379793104 cites W3197251944 @default.
- W4379793104 cites W3203779892 @default.
- W4379793104 cites W4206710086 @default.
- W4379793104 cites W4220743997 @default.
- W4379793104 doi "https://doi.org/10.3389/fimmu.2023.1209323" @default.
- W4379793104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37350969" @default.
- W4379793104 hasPublicationYear "2023" @default.
- W4379793104 type Work @default.
- W4379793104 citedByCount "0" @default.
- W4379793104 crossrefType "journal-article" @default.
- W4379793104 hasAuthorship W4379793104A5000801878 @default.
- W4379793104 hasAuthorship W4379793104A5002479149 @default.
- W4379793104 hasAuthorship W4379793104A5017755999 @default.
- W4379793104 hasAuthorship W4379793104A5022919112 @default.
- W4379793104 hasAuthorship W4379793104A5028702225 @default.
- W4379793104 hasAuthorship W4379793104A5041841487 @default.
- W4379793104 hasAuthorship W4379793104A5044870711 @default.
- W4379793104 hasBestOaLocation W43797931041 @default.
- W4379793104 hasConcept C126322002 @default.
- W4379793104 hasConcept C151956035 @default.
- W4379793104 hasConcept C187212893 @default.
- W4379793104 hasConcept C203014093 @default.
- W4379793104 hasConcept C2776572573 @default.
- W4379793104 hasConcept C2780640218 @default.
- W4379793104 hasConcept C2781137167 @default.
- W4379793104 hasConcept C34626388 @default.
- W4379793104 hasConcept C50382708 @default.
- W4379793104 hasConcept C71924100 @default.
- W4379793104 hasConceptScore W4379793104C126322002 @default.
- W4379793104 hasConceptScore W4379793104C151956035 @default.
- W4379793104 hasConceptScore W4379793104C187212893 @default.
- W4379793104 hasConceptScore W4379793104C203014093 @default.
- W4379793104 hasConceptScore W4379793104C2776572573 @default.
- W4379793104 hasConceptScore W4379793104C2780640218 @default.
- W4379793104 hasConceptScore W4379793104C2781137167 @default.
- W4379793104 hasConceptScore W4379793104C34626388 @default.
- W4379793104 hasConceptScore W4379793104C50382708 @default.
- W4379793104 hasConceptScore W4379793104C71924100 @default.
- W4379793104 hasLocation W43797931041 @default.
- W4379793104 hasLocation W43797931042 @default.
- W4379793104 hasLocation W43797931043 @default.
- W4379793104 hasOpenAccess W4379793104 @default.
- W4379793104 hasPrimaryLocation W43797931041 @default.
- W4379793104 hasRelatedWork W1970531127 @default.
- W4379793104 hasRelatedWork W2289159721 @default.
- W4379793104 hasRelatedWork W2751315620 @default.
- W4379793104 hasRelatedWork W2969610835 @default.
- W4379793104 hasRelatedWork W2990854950 @default.
- W4379793104 hasRelatedWork W3025317959 @default.
- W4379793104 hasRelatedWork W3161101627 @default.
- W4379793104 hasRelatedWork W3204677152 @default.
- W4379793104 hasRelatedWork W3210886047 @default.
- W4379793104 hasRelatedWork W4362468290 @default.
- W4379793104 hasVolume "14" @default.
- W4379793104 isParatext "false" @default.
- W4379793104 isRetracted "false" @default.
- W4379793104 workType "article" @default.