Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379793427> ?p ?o ?g. }
- W4379793427 endingPage "9825" @default.
- W4379793427 startingPage "9825" @default.
- W4379793427 abstract "By generating protein diversity, alternative splicing provides an important oncogenic pathway. Isocitrate dehydrogenase (IDH) 1 and 2 mutations and 1p/19q co-deletion have become crucial for the novel molecular classification of diffuse gliomas, which also incorporates DNA methylation profiling. In this study, we have carried out a bioinformatics analysis to examine the impact of the IDH mutation, as well as the 1p/19q co-deletion and the glioma CpG island methylator phenotype (G-CIMP) status on alternative splicing in a cohort of 662 diffuse gliomas from The Cancer Genome Atlas (TCGA). We identify the biological processes and molecular functions affected by alternative splicing in the various glioma subgroups and provide evidence supporting the important contribution of alternative splicing in modulating epigenetic regulation in diffuse gliomas. Targeting the genes and pathways affected by alternative splicing might provide novel therapeutic opportunities against gliomas." @default.
- W4379793427 created "2023-06-09" @default.
- W4379793427 creator A5013957833 @default.
- W4379793427 creator A5038294182 @default.
- W4379793427 creator A5068671173 @default.
- W4379793427 creator A5073263363 @default.
- W4379793427 creator A5081167968 @default.
- W4379793427 date "2023-06-06" @default.
- W4379793427 modified "2023-10-18" @default.
- W4379793427 title "Impact of IDH Mutations, the 1p/19q Co-Deletion and the G-CIMP Status on Alternative Splicing in Diffuse Gliomas" @default.
- W4379793427 cites W1497063493 @default.
- W4379793427 cites W1812256879 @default.
- W4379793427 cites W1981629946 @default.
- W4379793427 cites W1988756388 @default.
- W4379793427 cites W1989683090 @default.
- W4379793427 cites W2015217788 @default.
- W4379793427 cites W2019226300 @default.
- W4379793427 cites W2021630037 @default.
- W4379793427 cites W2025183726 @default.
- W4379793427 cites W2045807926 @default.
- W4379793427 cites W2058417905 @default.
- W4379793427 cites W2059297417 @default.
- W4379793427 cites W2063946332 @default.
- W4379793427 cites W2071930821 @default.
- W4379793427 cites W2076057425 @default.
- W4379793427 cites W2085293170 @default.
- W4379793427 cites W2085860799 @default.
- W4379793427 cites W2087819495 @default.
- W4379793427 cites W2102312968 @default.
- W4379793427 cites W2105528101 @default.
- W4379793427 cites W2111988427 @default.
- W4379793427 cites W2114843025 @default.
- W4379793427 cites W2123402634 @default.
- W4379793427 cites W2126817554 @default.
- W4379793427 cites W2130410032 @default.
- W4379793427 cites W2141224543 @default.
- W4379793427 cites W2144154285 @default.
- W4379793427 cites W2146512944 @default.
- W4379793427 cites W2149441684 @default.
- W4379793427 cites W2157219413 @default.
- W4379793427 cites W2164219809 @default.
- W4379793427 cites W2165547003 @default.
- W4379793427 cites W2176981778 @default.
- W4379793427 cites W2179438025 @default.
- W4379793427 cites W2257254975 @default.
- W4379793427 cites W2269054226 @default.
- W4379793427 cites W2270927656 @default.
- W4379793427 cites W2340746011 @default.
- W4379793427 cites W2429042322 @default.
- W4379793427 cites W2521492299 @default.
- W4379793427 cites W2566753678 @default.
- W4379793427 cites W2589225545 @default.
- W4379793427 cites W2765807143 @default.
- W4379793427 cites W2794804602 @default.
- W4379793427 cites W2795877840 @default.
- W4379793427 cites W2809668203 @default.
- W4379793427 cites W2910571353 @default.
- W4379793427 cites W2945794440 @default.
- W4379793427 cites W2950312017 @default.
- W4379793427 cites W2951388646 @default.
- W4379793427 cites W2977107688 @default.
- W4379793427 cites W2997022986 @default.
- W4379793427 cites W3000614249 @default.
- W4379793427 cites W3004094096 @default.
- W4379793427 cites W3014561685 @default.
- W4379793427 cites W3015988344 @default.
- W4379793427 cites W3036630705 @default.
- W4379793427 cites W3096828292 @default.
- W4379793427 cites W3132948359 @default.
- W4379793427 cites W3180083742 @default.
- W4379793427 cites W3200317384 @default.
- W4379793427 cites W3211446888 @default.
- W4379793427 cites W4205316981 @default.
- W4379793427 cites W4210304148 @default.
- W4379793427 cites W4287485565 @default.
- W4379793427 cites W4287837153 @default.
- W4379793427 cites W4309604651 @default.
- W4379793427 cites W4366742995 @default.
- W4379793427 doi "https://doi.org/10.3390/ijms24129825" @default.
- W4379793427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37372972" @default.
- W4379793427 hasPublicationYear "2023" @default.
- W4379793427 type Work @default.
- W4379793427 citedByCount "0" @default.
- W4379793427 crossrefType "journal-article" @default.
- W4379793427 hasAuthorship W4379793427A5013957833 @default.
- W4379793427 hasAuthorship W4379793427A5038294182 @default.
- W4379793427 hasAuthorship W4379793427A5068671173 @default.
- W4379793427 hasAuthorship W4379793427A5073263363 @default.
- W4379793427 hasAuthorship W4379793427A5081167968 @default.
- W4379793427 hasBestOaLocation W43797934271 @default.
- W4379793427 hasConcept C104317684 @default.
- W4379793427 hasConcept C134935766 @default.
- W4379793427 hasConcept C140173407 @default.
- W4379793427 hasConcept C150194340 @default.
- W4379793427 hasConcept C181199279 @default.
- W4379793427 hasConcept C190727270 @default.
- W4379793427 hasConcept C194583182 @default.
- W4379793427 hasConcept C2777150147 @default.