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• W4379795087 abstract "Background Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease mainly affecting exocrine glands. Extraglandular manifestations play a major role in the long-term prognosis of the disease, and neurological manifestations seem common in pSS. The early detection of haematological and immunological parameters might improve the disease evolution of patients. Objectives The study aimed to evaluate the predictive potential of clinical, haematological and immunological elements for the development of neurologic manifestations in pSS patients, followed for 12 months. Methods We performed a retrospective study in a single center, with a total of 265 patients (131 pSS patients and 134 healthy controls). Clinical examinations, complete blood count, inflammatory and immunological parameters were registered at baseline, 6 months and 12 months, for 131 pSS patients. Results In pSS patients, cellular count, complement fractions, and Vitamin B12 values were significantly decreased compared to healthy subjects (p < 0.001), while, cellular ratio- NLR, PLR, immunological and inflammatory parameters were significantly increased (p < 0.001) in the pSS patients. Likewise, the comparison at baseline and at every 6 months, of cellular ratios, total proteins, and gammaglobulins and disease scores revealed exponentially increased values, in pSS patients with PN. The occurrence of PN was positively correlated with neutrophils and platelets (p < 0.05), and negatively correlated with lymphocytes (p < 0.05). NLR and PLR also revealed significant positive correlations with the emergence of PN in pSS (p < 0.05), while for total proteins, and Vitamin B12 the correlation was negative (p < 0.05). The multivariate analysis confirmed the independent predictive character for PN emergence in pSS for NLR (CI95% 0.034 to 0.254, p < 0.010), gammaglobulins (CI95% -0.409 to -0.114, p < 0.001) and vitamin B12 (CI95% -0.001 to -0.001, p < 0.001). Conclusion High values for hematologic and immunological parameters were identified at baseline, while their persistent modifications during the follow-up period were observed in pSS patients with PN. NLR, gammaglobulins and vitamin B12, parameters that could become predictors for the early detection of patients at risk for the development of PN. References [1]Patel R, Shahane A. The epidemiology of Sjögren’s syndrome. Clin Epidemiol . 2014 Jul 30; 6:247-55. [2]Cafaro G, Perricone C, Carubbi F, Baldini C, Quartuccio L, Priori R, Berardicurti O, Ferro F, Gandolfo S, Gattamelata A, Giacomelli R, De Vita S, Gerli R, Bartoloni E. Peripheral Nervous System Involvement in Sjögren’s Syndrome: Analysis of a Cohort From the Italian Research Group on Sjögren’s Syndrome. Front Immunol. 2021 Mar 24 ;12:615656. [3]Fan G, Dai F, Chen S, Sun Y, Qian H, Yang G, Liu Y, Shi G. Neurological Involvement in Patients With Primary Sjögren’s Syndrome. J Clin Rheumatol. 2021 Mar 1;27(2):50-55. doi: 10.1097/RHU.0000000000001128. PMID: 33617165; PMCID: PMC7899220. [4]Jamilloux Y, Magy L, Hurtevent JF, Gondran G, de Seze J, Launay D, Ly KH, Lambert M, Hachulla E, Hatron PY, Vidal E, Fauchais AL. Immunological profiles determine neurological involvement in Sjögren’s syndrome. Eur J Intern Med. 2014 Feb;25(2):177-81. doi: 10.1016/j.ejim.2013.10.005. Epub 2013 Oct 29. PMID: 24176941. [5]Mihai A, Caruntu A, Opris-Belinski D, Jurcut C, Dima A, Caruntu C, Ionescu R. The Predictive Role of Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), Monocytes-to-Lymphocyte Ratio (MLR) and Gammaglobulins for the Development of Cutaneous Vasculitis Lesions in Primary Sjögren’s Syndrome. J Clin Med. 2022 Sep 21 ;11(19):5525. [6]Urbanski G, Chabrun F, Schaepelynck B, May M, Loiseau M, Schlumberger E, Delattre E, Lavigne C, Lacombe V. Association of Primary Sjögren’s Syndrome and Vitamin B12 Deficiency: A Cross-Sectional Case-Control Study. J Clin Med. 2020 Dec 16;9(12):4063. doi: 10.3390/jcm9124063. PMID: 33339380; PMCID: PMC7765802. Acknowledgements: NIL. Disclosure of Interests None Declared." @default.
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• W4379795087 date "2023-05-30" @default.
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• W4379795087 title "AB0600 THE FOLLOW-UP OF pSS PATIENTS WITH PERIPHERAL NEUROLOGIC INVOLVEMENT IN A TERTIARY CENTER" @default.
• W4379795087 doi "https://doi.org/10.1136/annrheumdis-2023-eular.734" @default.
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