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• W4379795172 abstract "Background Rheumatoid Arthritis (RA) is associated with increased cardiovascular (CV) morbidity and mortality and osteometabolic alterations risk, associated with chronic inflammation, the use of glucocorticoids (GC) and the reduced physical exercise. [1] Objectives The objective of the study is to cross-sectionally estimate cardiovascular risk and osteometabolic status in patients (pts) with RA and to evaluate the association with some disease parameters such as positivity of autoantibodies, disease activity and steroid therapy. Methods At the current time, 61 consecutive pts with diagnosis of RA, admitted to the Rheumatology Unit of the University Hospital of Turin, were prospectively recruited and assessed for cardiometabolic risk by the Endocrinology Unit, by undergoing laboratory and instrumental tests. Results The following prevalences were observed: arterial hypertension (52%), type 2 diabetes mellitus (7%), dyslipidemia (56%), osteoporosis (42%), and vertebral fracture (30%). At the univariate analysis, the enrolled pts were divided according to serodiagnosis, GC therapy and disease remission. No statistically significant results were highlighted stratifying population by serodiagnosis. Pts with high disease activity showed lower bone mineral density (BMD) values [BMD femoral trochanter: 0.53± 0.08 vs 0.60 ± 0.08 (g/m 2 ), p=0.031] and T-score value on bone densitometry [T-score Femoral total: -1.88 ± 0.53 vs -1.07 ± 0.83, p=0.005], higher percentage of osteoporosis [67% vs 27%, p=0.047] and vertebral fractures [60% vs 12%, p=0.001], and higher sarcopenia score [SARC-F: 5 (3-7) vs 2 (2-4), p=0.020], in comparison with pts with remission disease. These differences were not confirmed when the population was divided according to the use of GC therapy. For CV risk factors, disease activity group showed a trend of higher prevalence compared to remission group, but without reaching statistical significance. At the multivariate analysis, advanced age (p=0.001), GC therapy (p=0.021) and copeptin (p=0.002) showed an inverse association and lumbar T-score (p=0.002) a direct one with lumbar trabecular bone score (TBS). Moreover, male gender (p=0.001) revealed a direct and significant association, while copeptin (p=0.086) an inverse and not significant one with percentage of lean mass on total densitometry, correcting for advanced age, duration of disease, GC therapy, and disease activity. In the last model, advanced age (p<0.001) and copeptin (p<0.001) showed a direct and significant association with HeartSCORE, correcting for parameters of disease while serodiagnosis, duration of disease, GC therapy, and disease activity. Table 1. Multivariate linear regression analysis Covariates associated with lumbar TBS B-coefficient CI 95% p-value Age -0.005 (-0.007- -0.002) 0.001 GC -0.068 (-0.125- -0.011) 0.021 T-Score 0.049 (0.020-0.079) 0.002 Copeptin -0.014 (-0.023- -0.006) 0.002 Covariates associated with HeartSCORE cardiovascular risk score B-coefficient CI 95% p-value Age 0.242 (0.180-0.304) <0.001 Duration of disease -0.045 (-0.099-0.008) 0.096 RF and/or ACPA + -0.224 (-1.855-1.407) 0.782 GC 0.840 (-0.454-2.135) 0.195 Copeptin 0.345 (0.172-0.518) <0.001 Remission 0.502 (-0.848-1.853) 0.454 Conclusion At univariate analysis osteometabolic alterations were associated with disease activity, but not with GC therapy and serodiagnosis. At the multivariate analysis, the association of disease activity and TBS values, did not reach the statistical significance, probably for the loss of statistical power. However, GC therapy, as well as advanced age, low lumbar T-score and high value of copeptin, remained independently associated with lower TBS value. Disease parameters were not associated with lower percentage of lean mass at total body densitometry and higher HeartSCORE values, while advanced age and copeptin were associated with bone health and cardiovascular risk. Reference [1] Mackey RH et al. Rheum Dis Clin North Am 2018. Acknowledgements: NIL. Disclosure of Interests None Declared." @default.
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• W4379795172 date "2023-05-30" @default.
• W4379795172 modified "2023-10-18" @default.
• W4379795172 title "AB0356 EVALUATION OF CARDIOVASCULAR RISK AND OSTEOMETABOLIC ALTERATIONS IN A POPULATION OF PATIENTS AFFECTED BY RHEUMATOID ARTHRITIS: PRELIMINARY RESULTS OF A MULTIDISCIPLINARY PROSPECTIVE STUDY" @default.
• W4379795172 doi "https://doi.org/10.1136/annrheumdis-2023-eular.1767" @default.
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