FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379799711> ?p ?o ?g. }

• W4379799711 endingPage "1369" @default.
• W4379799711 startingPage "1369" @default.
• W4379799711 abstract "Background Hashimoto’s thyroiditis (HT) is an organ-specific autoimmune disease that is not rare in RA. Hypothyroidism caused by HT can affect the prognosis and quality of life in patients with RA [1]. Many studies showed that immune cells play a critical role in HT [2-3]. However, the alterations of lymphocyte subsets in RA patients with HT are unclear. Objectives This study aimed to assess the absolute numbers and proportions of peripheral lymphocyte subsets in RA with HT and investigate the clinical significance. Methods A total of 1636 RA patients and 54 gender- and age-matched healthy controls (HCs) were enrolled in this study. Patients were divided into RA-non-HT and RA-HT groups according to the thyroid peroxidase antibody (TPOAb) and thyroid globulin antibody (TgAb). Peripheral lymphocyte subsets of all participants were assessed by flow cytometry. All clinical and laboratory data were analyzed by SPSS 23.0. Results Among 30 (1.83%) RA-HT patients, there were more female ( P =0.005), suggesting female was more susceptible to developing HT (Figure 1A). In addition, there were higher levels of erythrocyte sedimentation rate (ESR) ( P =0.045) and C-reactive protein (CRP) ( P =0.042) than those in RA-non-HT (Figure 1B-C). Compared with those of HCs and RA-non-HT, the level of circulating Th17 in RA-HT patients was significantly increased ( P <0.05), while those of Tregs decreased ( P <0.05), leading to a higher ratio of Th17/Treg ( P <0.01). Notably, the level of B cells and Th1 cells, as well as the Th1/Th2 ratio, increased in the RA-HT compared with those of the RA-non-HT ( P <0.05) (Figure 1D-F). Conclusion The occurrence of RA-HT is closely related to female patients with high disease activity. Disorders of lymphocyte subsets, especially Th17/Treg imbalance, may contribute to HT in RA, which deserves more clinical attention. References [1]Conigliaro P, D’Antonio A, Pinto S, et al. Autoimmune thyroid disorders and rheumatoid arthritis: A bidirectional interplay. Autoimmun Rev. 2020 Jun;19(6):102529. [2]Weetman AP. An update on the pathogenesis of Hashimoto’s thyroiditis. J Endocrinol Invest. 2021 May;44(5):883-890. [3]Pyzik A, Grywalska E, Matyjaszek-Matuszek B, et al. Immune disorders in Hashimoto’s thyroiditis: what do we know so far? J Immunol Res. 2015;2015:979167. Acknowledgements: NIL. Disclosure of Interests None Declared." @default.
• W4379799711 created "2023-06-09" @default.
• W4379799711 creator A5022335672 @default.
• W4379799711 creator A5084300721 @default.
• W4379799711 creator A5086284188 @default.
• W4379799711 creator A5032516487 @default.
• W4379799711 date "2023-05-30" @default.
• W4379799711 modified "2023-10-18" @default.
• W4379799711 title "AB0370 DISORDERS OF PERIPHERAL LYMPHOCYTE SUBSETS IN RHEUMATOID ARTHRITIS PATIENTS COMPLICATED WITH HASHIMOTO’S THYROIDITIS" @default.
• W4379799711 doi "https://doi.org/10.1136/annrheumdis-2023-eular.5521" @default.
• W4379799711 hasPublicationYear "2023" @default.
• W4379799711 type Work @default.
• W4379799711 citedByCount "0" @default.
• W4379799711 crossrefType "journal-article" @default.
• W4379799711 hasAuthorship W4379799711A5022335672 @default.
• W4379799711 hasAuthorship W4379799711A5032516487 @default.
• W4379799711 hasAuthorship W4379799711A5084300721 @default.
• W4379799711 hasAuthorship W4379799711A5086284188 @default.
• W4379799711 hasBestOaLocation W43797997111 @default.
• W4379799711 hasConcept C126322002 @default.
• W4379799711 hasConcept C134018914 @default.
• W4379799711 hasConcept C203014093 @default.
• W4379799711 hasConcept C2777575956 @default.
• W4379799711 hasConcept C2777761686 @default.
• W4379799711 hasConcept C2778143017 @default.
• W4379799711 hasConcept C2778696486 @default.
• W4379799711 hasConcept C526584372 @default.
• W4379799711 hasConcept C71924100 @default.
• W4379799711 hasConcept C8891405 @default.
• W4379799711 hasConcept C90924648 @default.
• W4379799711 hasConceptScore W4379799711C126322002 @default.
• W4379799711 hasConceptScore W4379799711C134018914 @default.
• W4379799711 hasConceptScore W4379799711C203014093 @default.
• W4379799711 hasConceptScore W4379799711C2777575956 @default.
• W4379799711 hasConceptScore W4379799711C2777761686 @default.
• W4379799711 hasConceptScore W4379799711C2778143017 @default.
• W4379799711 hasConceptScore W4379799711C2778696486 @default.
• W4379799711 hasConceptScore W4379799711C526584372 @default.
• W4379799711 hasConceptScore W4379799711C71924100 @default.
• W4379799711 hasConceptScore W4379799711C8891405 @default.
• W4379799711 hasConceptScore W4379799711C90924648 @default.
• W4379799711 hasIssue "Suppl 1" @default.
• W4379799711 hasLocation W43797997111 @default.
• W4379799711 hasOpenAccess W4379799711 @default.
• W4379799711 hasPrimaryLocation W43797997111 @default.
• W4379799711 hasRelatedWork W1981968121 @default.
• W4379799711 hasRelatedWork W2011960454 @default.
• W4379799711 hasRelatedWork W2021841321 @default.
• W4379799711 hasRelatedWork W2060603500 @default.
• W4379799711 hasRelatedWork W2070295037 @default.
• W4379799711 hasRelatedWork W2072870574 @default.
• W4379799711 hasRelatedWork W2155312245 @default.
• W4379799711 hasRelatedWork W2163236351 @default.
• W4379799711 hasRelatedWork W2411536504 @default.
• W4379799711 hasRelatedWork W2748952813 @default.
• W4379799711 hasVolume "82" @default.
• W4379799711 isParatext "false" @default.
• W4379799711 isRetracted "false" @default.
• W4379799711 workType "article" @default.