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- W4379800288 abstract "Background: Due to the increased incidence and prevalence of type 2 diabetes mellitus, there is increased need for the search of drugs that may be useful in preventing/delaying the onset of this disease.
 Objective: To compare the preventive effects of losartan and pioglitazone on the development of type 2 diabetes mellitus in a rat model fed on a high fat diet.
 Methods: Study was conducted on 45 Sprague-Dawley rats divided into three randomized groups. All the rats were fed a high fat diet meant for inducing type 2 diabetes. Pioglitazone or losartan was given to the rats in group B and C respectively. Fasting blood glucose levels and body weight were determined weekly. At the end of the 12 week study period, Serum Insulin and CRP (C-Reactive Protein) levels were also determined.
 Results: Rats in groups B and C gained less weight and had lower fasting BSL than those in control group A. Results show that the mean serum insulin and CRP levels were significantly low in group B and C as compared to those in group A while difference between group B and C was statistically insignificant. The number of diabetic rats in group B and C was significantly lower as compared to group A at the end of study. Number of diabetic rats remained constant in pioglitazone treated rats after 10th week of study, while it kept on increasing in losartan treated group.
 Conclusion: Pioglitazone delays and prevents development of type 2 diabetes while losartan only has a delaying effect." @default.
- W4379800288 created "2023-06-09" @default.
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- W4379800288 date "2013-03-01" @default.
- W4379800288 modified "2023-10-01" @default.
- W4379800288 title "PREVENTION OF DEVELOPMENT OF TYPE 2 DIABETES MELLITUS BY LOSARTAN IN COMPARISON WITH PIOGLITAZONE IN A RAT MODEL" @default.
- W4379800288 doi "https://doi.org/10.51642/ppmj.v24i4.211" @default.
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