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- W4379802008 abstract "Naringin exists in a wide range of Chinese herbal medicine and has proven to possess several pharmacological properties. In this study, PC12, HepG2 cells, and female <em>Drosophila melanogaster</em> were used to investigate the antioxidative and anti-aging effects of naringin and explore the underlying mechanisms. The results showed that naringin inhibited H<sub>2</sub>O<sub>2</sub>-induced decline in cell viability and decreased the content of reactive oxygen species in cells. Meanwhile, naringin prolonged the lifespan of flies, enhanced the abilities of climbing and the resistance to stress, improved the activities of antioxidant enzymes, and decreased malondialdehyde content. Naringin also improved intestinal barrier dysfunction and reduced abnormal proliferation of intestinal stem cells. Moreover, naringin down-regulated the mRNA expressions of <em>inr</em>, <em>chico</em>, <em>pi3k</em>, and <em>akt-1</em>, and up-regulated the mRNA expressions of <em>dilp2</em>, <em>dilp3</em>, <em>dilp5</em>, and <em>foxo</em>, thereby activating autophagy-related genes and increasing the number of lysosomes. Furthermore, the mutant stocks assays and computer molecular simulation results further indicated that naringin delayed aging by inhibiting the IIS pathway and activating the autophagy pathway, which was consistent with the result of network pharmacological predictions." @default.
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- W4379802008 date "2023-06-01" @default.
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- W4379802008 title "Naringin ameliorates H <sub>2</sub>O <sub>2</sub>-induced oxidative damage in cells and prolongs the lifespan of female <em>Drosophila melanogaster</em> via the insulin signaling pathway" @default.
- W4379802008 doi "https://doi.org/10.26599/fshw.2022.9250103" @default.
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