FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379883118> ?p ?o ?g. }

• W4379883118 endingPage "104624" @default.
• W4379883118 startingPage "104624" @default.
• W4379883118 abstract "Although it has been reported that the co-delivery of drugs can be beneficial to patients to kill breast cancer cells, the delivery methods could only be employed to effectively encapsulate individual curcumin (CUR) or piperine (PIP) molecules due to their different molecular polarities. Therefore, in the current research, an attempt was made to overcome the limitation of the co-delivery of CUR and PIP nanoparticles for breast cancer therapy. To manage locoregional breast cancer recurrence, a magnetic co-delivery system of CUR and PIP against MCF-7 breast cancer cells was examined. CUR and PIP demonstrated synergistic effects for breast cancer therapy when utilized together. However, due to the different polarities of CUR and PIP, it was difficult to co-encapsulate them in conventional delivery systems. Moreover, their low bioavailability, hydrophobic nature, and low cellular uptake limit its usage for cancer therapy. In the current study, to overcome the issues and improves its therapeutic efficacy, CUR and PIP-loaded zein/chitosan-coated iron oxide (Chit-PIP/[email protected]3O4) were prepared via a combination of anti-solvent precipitation and layer-by-layer deposition. X-ray diffraction (XRD) analysis revealed magnetite cores and also showed that the binding process did not change the Fe3O4 phase. A vibrational sample magnetometer confirmed that the saturation of sample magnetization was 60 and 40 emu/g for pure Fe3O4 and nanocomposite, respectively. Nanoparticles with an average size of 20 nm were prepared. The drug-loading content of CUR and PIP was approximately 18% and 16%, respectively. CUR and PIP release from Chit-PIP/[email protected]3O4 was faster at the extracellular pH of around tumors (6.5) than in normal tissues (7.4), an interesting degree of pH sensitivity. The MTT assay exhibited that PIP/CUR-loaded polymeric magnetic nanoparticles had significant synergistic cytotoxicity against MCF-7 cells compared with other groups. These results demonstrate that the combination of dual-drug loaded polymeric magnetic nanoparticles holds promise for the targeted treatment of cancer cells." @default.
• W4379883118 created "2023-06-09" @default.
• W4379883118 creator A5003523549 @default.
• W4379883118 creator A5012011033 @default.
• W4379883118 creator A5023571572 @default.
• W4379883118 creator A5027867925 @default.
• W4379883118 creator A5033544451 @default.
• W4379883118 creator A5047307154 @default.
• W4379883118 creator A5072745359 @default.
• W4379883118 date "2023-09-01" @default.
• W4379883118 modified "2023-10-11" @default.
• W4379883118 title "Efficient synergistic combination effect of curcumin with piperine by polymeric magnetic nanoparticles for breast cancer treatment" @default.
• W4379883118 cites W1488734028 @default.
• W4379883118 cites W1749145259 @default.
• W4379883118 cites W1974037606 @default.
• W4379883118 cites W1986684459 @default.
• W4379883118 cites W2000068330 @default.
• W4379883118 cites W2015537219 @default.
• W4379883118 cites W2017139362 @default.
• W4379883118 cites W2018076193 @default.
• W4379883118 cites W2021813758 @default.
• W4379883118 cites W2029032257 @default.
• W4379883118 cites W2033061169 @default.
• W4379883118 cites W2037984983 @default.
• W4379883118 cites W2040793307 @default.
• W4379883118 cites W2041003037 @default.
• W4379883118 cites W2047925917 @default.
• W4379883118 cites W2054981131 @default.
• W4379883118 cites W2058865733 @default.
• W4379883118 cites W2074396995 @default.
• W4379883118 cites W2076118376 @default.
• W4379883118 cites W2088242076 @default.
• W4379883118 cites W2108493892 @default.
• W4379883118 cites W2108615682 @default.
• W4379883118 cites W2115741721 @default.
• W4379883118 cites W2124684091 @default.
• W4379883118 cites W2142164810 @default.
• W4379883118 cites W2143463421 @default.
• W4379883118 cites W2156661377 @default.
• W4379883118 cites W2169764196 @default.
• W4379883118 cites W2169972304 @default.
• W4379883118 cites W2172812865 @default.
• W4379883118 cites W2236600025 @default.
• W4379883118 cites W2324499350 @default.
• W4379883118 cites W2396165980 @default.
• W4379883118 cites W2510556729 @default.
• W4379883118 cites W2529076618 @default.
• W4379883118 cites W2530865780 @default.
• W4379883118 cites W2532120864 @default.
• W4379883118 cites W2552653244 @default.
• W4379883118 cites W2606120703 @default.
• W4379883118 cites W2618037986 @default.
• W4379883118 cites W2727357448 @default.
• W4379883118 cites W2740867860 @default.
• W4379883118 cites W2754042219 @default.
• W4379883118 cites W2755451938 @default.
• W4379883118 cites W2765299354 @default.
• W4379883118 cites W2767724846 @default.
• W4379883118 cites W2769722271 @default.
• W4379883118 cites W2781676508 @default.
• W4379883118 cites W2783046994 @default.
• W4379883118 cites W2786238764 @default.
• W4379883118 cites W2786606492 @default.
• W4379883118 cites W2791898532 @default.
• W4379883118 cites W2794786866 @default.
• W4379883118 cites W2799569187 @default.
• W4379883118 cites W2803674762 @default.
• W4379883118 cites W2807410315 @default.
• W4379883118 cites W2809008737 @default.
• W4379883118 cites W2883251420 @default.
• W4379883118 cites W2890753467 @default.
• W4379883118 cites W2893249788 @default.
• W4379883118 cites W2895648077 @default.
• W4379883118 cites W2901811731 @default.
• W4379883118 cites W2913363035 @default.
• W4379883118 cites W2917829455 @default.
• W4379883118 cites W2942339986 @default.
• W4379883118 cites W2994772830 @default.
• W4379883118 cites W3009164764 @default.
• W4379883118 cites W3083864310 @default.
• W4379883118 cites W3135896406 @default.
• W4379883118 cites W3137706823 @default.
• W4379883118 cites W3164645880 @default.
• W4379883118 cites W3165436945 @default.
• W4379883118 cites W3206556946 @default.
• W4379883118 cites W4214924901 @default.
• W4379883118 cites W4281918491 @default.
• W4379883118 doi "https://doi.org/10.1016/j.jddst.2023.104624" @default.
• W4379883118 hasPublicationYear "2023" @default.
• W4379883118 type Work @default.
• W4379883118 citedByCount "1" @default.
• W4379883118 crossrefType "journal-article" @default.
• W4379883118 hasAuthorship W4379883118A5003523549 @default.
• W4379883118 hasAuthorship W4379883118A5012011033 @default.
• W4379883118 hasAuthorship W4379883118A5023571572 @default.
• W4379883118 hasAuthorship W4379883118A5027867925 @default.
• W4379883118 hasAuthorship W4379883118A5033544451 @default.
• W4379883118 hasAuthorship W4379883118A5047307154 @default.

• next