FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379883130> ?p ?o ?g. }

• W4379883130 abstract "Abstract Oncogenic Kaposi’s sarcoma-associated herpesvirus (KSHV) consists of latent and lytic replication phases, both of which are important for the development of KSHV- related cancers. As one of the most abundant RNA modifications, N 6 -methyladenosine (m 6 A) and its related complexes regulate KSHV life cycle. However, the role of METTL16, a new RNA methyltransferase, in KSHV life cycle remains unknown. In this study, we have identified a suppressive role of METTL16 in KSHV lytic replication. METTL16 knockdown increased while METTL16 overexpression reduced KSHV lytic replication. METTL16 binding to and writing of m 6 A on MAT2A transcript are essential for its splicing, maturation and expression. As a rate-limiting enzyme in the methionine- S -adenosylmethionine (SAM) cycle, MAT2A catalyzes the conversion of L-methionine to SAM required for the transmethylation of protein, DNA and RNA, transamination of polyamines, and transsulfuration of cystathionine. Consequently, knockdown or chemical inhibition of MAT2A reduced intracellular SAM level and enhanced KSHV lytic replication. In contrast, SAM treatment was sufficient to inhibit KSHV lytic replication and reverse the effect of the enhanced KSHV lytic program caused by METTL16 or MAT2A knockdown. Mechanistically, METTL16 or MAT2A knockdown increased while SAM treatment decreased the intracellular reactive oxygen species level by altering glutathione level, which is essential for efficient KSHV lytic replication. These findings demonstrate that METTL16 suppresses KSHV lytic replication by modulating the SAM cycle to maintain intracellular SAM level and redox homeostasis, thus illustrating the linkage of KSHV life cycle with specific m 6 A modifications, and cellular metabolic and oxidative conditions." @default.
• W4379883130 created "2023-06-09" @default.
• W4379883130 creator A5010896860 @default.
• W4379883130 creator A5021032519 @default.
• W4379883130 creator A5025300076 @default.
• W4379883130 creator A5054856339 @default.
• W4379883130 creator A5055448380 @default.
• W4379883130 creator A5061582217 @default.
• W4379883130 creator A5068887242 @default.
• W4379883130 creator A5084681608 @default.
• W4379883130 date "2023-06-07" @default.
• W4379883130 modified "2023-10-02" @default.
• W4379883130 title "METTL16 Controls Kaposi’s Sarcoma-Associated Herpesvirus Replication by Regulating<i>S</i>-Adenosylmethionine Cycle" @default.
• W4379883130 cites W1541927927 @default.
• W4379883130 cites W1978001038 @default.
• W4379883130 cites W1981629946 @default.
• W4379883130 cites W1991807334 @default.
• W4379883130 cites W2010258747 @default.
• W4379883130 cites W2048349001 @default.
• W4379883130 cites W2051018605 @default.
• W4379883130 cites W2054101834 @default.
• W4379883130 cites W2066502941 @default.
• W4379883130 cites W2076378299 @default.
• W4379883130 cites W2082821736 @default.
• W4379883130 cites W2159051688 @default.
• W4379883130 cites W2165547003 @default.
• W4379883130 cites W2193471209 @default.
• W4379883130 cites W2327216023 @default.
• W4379883130 cites W2336857745 @default.
• W4379883130 cites W2462449071 @default.
• W4379883130 cites W2532091902 @default.
• W4379883130 cites W2538543247 @default.
• W4379883130 cites W2592780432 @default.
• W4379883130 cites W2616848081 @default.
• W4379883130 cites W2619595348 @default.
• W4379883130 cites W2749219966 @default.
• W4379883130 cites W2780168233 @default.
• W4379883130 cites W2803000225 @default.
• W4379883130 cites W2886443559 @default.
• W4379883130 cites W2892071256 @default.
• W4379883130 cites W2951335269 @default.
• W4379883130 cites W2953224225 @default.
• W4379883130 cites W2962780260 @default.
• W4379883130 cites W2981352311 @default.
• W4379883130 cites W3119450237 @default.
• W4379883130 cites W3133117790 @default.
• W4379883130 cites W3174703739 @default.
• W4379883130 cites W3186346120 @default.
• W4379883130 cites W3194230805 @default.
• W4379883130 cites W3207828662 @default.
• W4379883130 cites W4211169877 @default.
• W4379883130 cites W4226149484 @default.
• W4379883130 cites W4229642588 @default.
• W4379883130 cites W4291991161 @default.
• W4379883130 cites W4327683163 @default.
• W4379883130 cites W4375862389 @default.
• W4379883130 doi "https://doi.org/10.1101/2023.06.07.544118" @default.
• W4379883130 hasPublicationYear "2023" @default.
• W4379883130 type Work @default.
• W4379883130 citedByCount "0" @default.
• W4379883130 crossrefType "posted-content" @default.
• W4379883130 hasAuthorship W4379883130A5010896860 @default.
• W4379883130 hasAuthorship W4379883130A5021032519 @default.
• W4379883130 hasAuthorship W4379883130A5025300076 @default.
• W4379883130 hasAuthorship W4379883130A5054856339 @default.
• W4379883130 hasAuthorship W4379883130A5055448380 @default.
• W4379883130 hasAuthorship W4379883130A5061582217 @default.
• W4379883130 hasAuthorship W4379883130A5068887242 @default.
• W4379883130 hasAuthorship W4379883130A5084681608 @default.
• W4379883130 hasBestOaLocation W43798831301 @default.
• W4379883130 hasConcept C104317684 @default.
• W4379883130 hasConcept C140704245 @default.
• W4379883130 hasConcept C1491633281 @default.
• W4379883130 hasConcept C159047783 @default.
• W4379883130 hasConcept C173396325 @default.
• W4379883130 hasConcept C182615771 @default.
• W4379883130 hasConcept C2522874641 @default.
• W4379883130 hasConcept C2776409557 @default.
• W4379883130 hasConcept C2780727368 @default.
• W4379883130 hasConcept C2780797929 @default.
• W4379883130 hasConcept C29537977 @default.
• W4379883130 hasConcept C55493867 @default.
• W4379883130 hasConcept C86803240 @default.
• W4379883130 hasConcept C95444343 @default.
• W4379883130 hasConceptScore W4379883130C104317684 @default.
• W4379883130 hasConceptScore W4379883130C140704245 @default.
• W4379883130 hasConceptScore W4379883130C1491633281 @default.
• W4379883130 hasConceptScore W4379883130C159047783 @default.
• W4379883130 hasConceptScore W4379883130C173396325 @default.
• W4379883130 hasConceptScore W4379883130C182615771 @default.
• W4379883130 hasConceptScore W4379883130C2522874641 @default.
• W4379883130 hasConceptScore W4379883130C2776409557 @default.
• W4379883130 hasConceptScore W4379883130C2780727368 @default.
• W4379883130 hasConceptScore W4379883130C2780797929 @default.
• W4379883130 hasConceptScore W4379883130C29537977 @default.
• W4379883130 hasConceptScore W4379883130C55493867 @default.
• W4379883130 hasConceptScore W4379883130C86803240 @default.
• W4379883130 hasConceptScore W4379883130C95444343 @default.
• W4379883130 hasLocation W43798831301 @default.
• W4379883130 hasOpenAccess W4379883130 @default.

• next