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• W4379932479 abstract "Background Sjogren’s syndrome (SS); is a chronic multisystem inflammatory autoimmune disease characterized by dry eyes and mouth, involving lymphocytic infiltration of the lacrimal and salivary glands. Glandular involvement and extraglandular symptoms involving various organs and systems can be seen in patients. It can be seen in all age groups, although it is most common in those aged 45-50 years. The average female/male incidence rate is 9/1. Objectives Our aim in this study is to present the demographic, clinical and serological characteristics of patients diagnosed with SS. Methods Our study included 466 patients diagnosed with SS according to the 2016 ACR/EULAR Classification Criteria. Age, gender, primary/secondary SS status of the patients; organ involvement, salivary gland biopsy and serological features were recorded. Descriptive statistics were given as mean±standard deviation, frequency (n), and percent (%). Results The mean age of 466 (433 females, 33 males) patients in the study was 55.4±13.5 years. The female/male ratio was 13/1. There were 408 (87.5%) patients with primary SS diagnosis and 58 (12.5%) patients with secondary SS diagnosis. 67% of patients with a diagnosis of secondary SS had rheumatoid arthritis. The most common clinical presentation complaints were dry eye (86%) and dry mouth (67.8%). In our study, anti-nuclear antibody positivity was found to be 83.4%, rheumatoid factor positivity was 22.1%. Ro-52 antibody was positive in 56.4% of the patients. As a result of the evaluation in terms of organ/system involvement; pulmonary involvement was found in 45 patients (9.6%). Moreover; primary biliary cirrhosis in 18 (3.8%) patients, adrenal insufficiency in 1 (0.2%) patient, chronic tubulointerstitial nephritis in 2 (0.4%) patients, crescentic glomerulonephritis in 1 (0.2%) patient, optic neuropathy was found in 1 (0.4%) patient, and lymphoma was found in 1 (0.2%) patient (Table 1). Conclusion Sjögren’s syndrome can affect almost any organ system, thus various systemic manifestations may occur. The disease is characterized by pleomorphic clinical manifestations, which can vary greatly in features and severity from one patient to another. Diagnosis of the disease is based on characteristic clinical signs and symptoms as well as specific tests including salivary gland histopathology and autoantibodies. Table 1. Demographic, Clinical and Serological Characteristics of Sjögren’s Syndrome Patients n % Primary SS 408 87,5 Secondary SS • Rheumatoid Arthritis • Systemic Sclerosis • Systemic Lupus Erythematosus 58 39 11 8 12,5 67,2 18,9 13,7 Salivary gland biopsy positivity 247 53 Dry mouth 316 67,8 Dry eye 401 86 Locomotor system • Arthritis/arthralgia 165 35,4 Organ/system involvement • Pulmonary İnvolvement • Primary Biliary Cirrhosis • Autoimmune Hepatitis • Vasculitis • Amyloidosis • Chronic Tubulointestial Nephritis • Kresentik Glomerülonefrit • Adrenal İnsufficiency • Optic Neuropathy • Lymphoma 45 18 3 4 1 2 1 1 1 9,6 3,8 0,6 0,8 0,2 0,4 0,2 0,2 0,2 Anti-Nuclear Antibody positivity 389 83,4 Ro-52 positivity 263 56,4 Rheumatoid factor positivity 103 22,1 REFERENCES: NIL. Acknowledgements: NIL. Disclosure of Interests None Declared." @default.
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• W4379932479 date "2023-05-30" @default.
• W4379932479 modified "2023-09-27" @default.
• W4379932479 title "AB0629 DEMOGRAPHIC, CLINICAL AND SEROLOGICAL CHARACTERISTICS OF SJÖGREN’S SYNDROME PATIENTS" @default.
• W4379932479 doi "https://doi.org/10.1136/annrheumdis-2023-eular.1179" @default.
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