FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379932503> ?p ?o ?g. }

• W4379932503 abstract "Abstract Glycolysis plays significant roles in reprogramming the metastatic tumor microenvironment. Many lncRNAs have been reported to function as oncogenes by regulating glycolysis. In the present study, we found that the expression of LINC02582 gradually increased from adjacent normal to colorectal cancer (CRC), especially in Stage IV tumor tissues, and high LINC02582 expression predicted poor survival, especially for patients with lung metastasis. Functionally, LINC02582 promoted the glycolysis and invasion of CRC cells in vitro and enhanced their lung metastasis in vivo. Mechanically, LINC02582 functioned as a ceRNA to regulate lactate dehydrogenase B (LDHB) expression via sponging miR-375, resulting in glycolysis of CRC cells and leading to their invasion and lung metastasis. Clinically, high LINC02582 and LDHB expression predicted poor survival of CRC patients. In conclusion, the present study identified LINC02582 as an onco-lncRNA in CRC and demonstrated that the combination of LINC02582 /miR375/LDHB may be a potential prognostic biomarker of CRC with lung metastasis." @default.
• W4379932503 created "2023-06-09" @default.
• W4379932503 creator A5002773556 @default.
• W4379932503 creator A5004095985 @default.
• W4379932503 creator A5011159665 @default.
• W4379932503 creator A5021201432 @default.
• W4379932503 creator A5026160567 @default.
• W4379932503 creator A5061293176 @default.
• W4379932503 creator A5077030865 @default.
• W4379932503 creator A5092120446 @default.
• W4379932503 date "2023-06-07" @default.
• W4379932503 modified "2023-09-27" @default.
• W4379932503 title "LINC02582 Sponges MiR-375 To Promote The Lung Metastasis Of Colorectal Cancer Via Lactate Dehydrogenase B Dependent Glycolysis" @default.
• W4379932503 cites W2054212408 @default.
• W4379932503 cites W2103502575 @default.
• W4379932503 cites W2105532921 @default.
• W4379932503 cites W2106030955 @default.
• W4379932503 cites W2160068229 @default.
• W4379932503 cites W2198153867 @default.
• W4379932503 cites W2234115940 @default.
• W4379932503 cites W2335029242 @default.
• W4379932503 cites W2519942994 @default.
• W4379932503 cites W2537551256 @default.
• W4379932503 cites W2557222435 @default.
• W4379932503 cites W2930633744 @default.
• W4379932503 cites W2932887409 @default.
• W4379932503 cites W2936931130 @default.
• W4379932503 cites W2937032868 @default.
• W4379932503 cites W2969489705 @default.
• W4379932503 cites W2969744316 @default.
• W4379932503 cites W2971469357 @default.
• W4379932503 cites W2979655074 @default.
• W4379932503 cites W3030244026 @default.
• W4379932503 cites W3155448088 @default.
• W4379932503 cites W3167964895 @default.
• W4379932503 doi "https://doi.org/10.21203/rs.3.rs-3017664/v1" @default.
• W4379932503 hasPublicationYear "2023" @default.
• W4379932503 type Work @default.
• W4379932503 citedByCount "0" @default.
• W4379932503 crossrefType "posted-content" @default.
• W4379932503 hasAuthorship W4379932503A5002773556 @default.
• W4379932503 hasAuthorship W4379932503A5004095985 @default.
• W4379932503 hasAuthorship W4379932503A5011159665 @default.
• W4379932503 hasAuthorship W4379932503A5021201432 @default.
• W4379932503 hasAuthorship W4379932503A5026160567 @default.
• W4379932503 hasAuthorship W4379932503A5061293176 @default.
• W4379932503 hasAuthorship W4379932503A5077030865 @default.
• W4379932503 hasAuthorship W4379932503A5092120446 @default.
• W4379932503 hasBestOaLocation W43799325031 @default.
• W4379932503 hasConcept C104317684 @default.
• W4379932503 hasConcept C121608353 @default.
• W4379932503 hasConcept C126322002 @default.
• W4379932503 hasConcept C145059251 @default.
• W4379932503 hasConcept C1491633281 @default.
• W4379932503 hasConcept C181199279 @default.
• W4379932503 hasConcept C20251656 @default.
• W4379932503 hasConcept C2776256026 @default.
• W4379932503 hasConcept C2777318727 @default.
• W4379932503 hasConcept C2777714996 @default.
• W4379932503 hasConcept C2779013556 @default.
• W4379932503 hasConcept C502942594 @default.
• W4379932503 hasConcept C526805850 @default.
• W4379932503 hasConcept C55493867 @default.
• W4379932503 hasConcept C62231903 @default.
• W4379932503 hasConcept C71924100 @default.
• W4379932503 hasConcept C77255625 @default.
• W4379932503 hasConcept C86803240 @default.
• W4379932503 hasConceptScore W4379932503C104317684 @default.
• W4379932503 hasConceptScore W4379932503C121608353 @default.
• W4379932503 hasConceptScore W4379932503C126322002 @default.
• W4379932503 hasConceptScore W4379932503C145059251 @default.
• W4379932503 hasConceptScore W4379932503C1491633281 @default.
• W4379932503 hasConceptScore W4379932503C181199279 @default.
• W4379932503 hasConceptScore W4379932503C20251656 @default.
• W4379932503 hasConceptScore W4379932503C2776256026 @default.
• W4379932503 hasConceptScore W4379932503C2777318727 @default.
• W4379932503 hasConceptScore W4379932503C2777714996 @default.
• W4379932503 hasConceptScore W4379932503C2779013556 @default.
• W4379932503 hasConceptScore W4379932503C502942594 @default.
• W4379932503 hasConceptScore W4379932503C526805850 @default.
• W4379932503 hasConceptScore W4379932503C55493867 @default.
• W4379932503 hasConceptScore W4379932503C62231903 @default.
• W4379932503 hasConceptScore W4379932503C71924100 @default.
• W4379932503 hasConceptScore W4379932503C77255625 @default.
• W4379932503 hasConceptScore W4379932503C86803240 @default.
• W4379932503 hasLocation W43799325031 @default.
• W4379932503 hasOpenAccess W4379932503 @default.
• W4379932503 hasPrimaryLocation W43799325031 @default.
• W4379932503 hasRelatedWork W1074259872 @default.
• W4379932503 hasRelatedWork W1965848638 @default.
• W4379932503 hasRelatedWork W1975859778 @default.
• W4379932503 hasRelatedWork W2263214330 @default.
• W4379932503 hasRelatedWork W2282846405 @default.
• W4379932503 hasRelatedWork W2732735609 @default.
• W4379932503 hasRelatedWork W2979503114 @default.
• W4379932503 hasRelatedWork W3014489910 @default.
• W4379932503 hasRelatedWork W3024376740 @default.
• W4379932503 hasRelatedWork W3029765564 @default.
• W4379932503 isParatext "false" @default.
• W4379932503 isRetracted "false" @default.

• next