FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379967411> ?p ?o ?g. }

• W4379967411 endingPage "1057" @default.
• W4379967411 startingPage "1048" @default.
• W4379967411 abstract "Key Points As a biomarker, urinary metabolites could bridge the gap between genetic abnormalities and phenotypes of diseases. We found that levels of betaine, choline, fumarate, citrate, and glucose were significantly correlated with kidney function and could predict kidney outcomes, providing prognostic biomarkers in CKD. Background Because CKD is caused by genetic and environmental factors, biomarker development through metabolomic analysis, which reflects gene-derived downstream effects and host adaptation to the environment, is warranted. Methods We measured the metabolites in urine samples collected from 789 patients at the time of kidney biopsy and from urine samples from 147 healthy participants using nuclear magnetic resonance. The composite outcome was defined as a 30% decline in eGFR, doubling of serum creatinine levels, or end-stage kidney disease. Results Among the 28 candidate metabolites, we identified seven metabolites showing ( 1 ) good discrimination between healthy controls and patients with stage 1 CKD and ( 2 ) a consistent change in pattern from controls to patients with advanced-stage CKD. Among the seven metabolites, betaine, choline, glucose, fumarate, and citrate showed significant associations with the composite outcome after adjustment for age, sex, eGFR, the urine protein–creatinine ratio, and diabetes. Furthermore, adding choline, glucose, or fumarate to traditional biomarkers, including eGFR and proteinuria, significantly improved the ability of the net reclassification improvement ( P < 0.05) and integrated discrimination improvement ( P < 0.05) to predict the composite outcome. Conclusion Urinary metabolites, including betaine, choline, fumarate, citrate, and glucose, were found to be significant predictors of the progression of CKD. As a signature of kidney injury–related metabolites, it would be warranted to monitor to predict the renal outcome." @default.
• W4379967411 created "2023-06-10" @default.
• W4379967411 creator A5002075968 @default.
• W4379967411 creator A5005659905 @default.
• W4379967411 creator A5009056330 @default.
• W4379967411 creator A5015505167 @default.
• W4379967411 creator A5022646032 @default.
• W4379967411 creator A5023568077 @default.
• W4379967411 creator A5023668588 @default.
• W4379967411 creator A5024161442 @default.
• W4379967411 creator A5025160124 @default.
• W4379967411 creator A5028024742 @default.
• W4379967411 creator A5033449275 @default.
• W4379967411 creator A5058857350 @default.
• W4379967411 creator A5061080152 @default.
• W4379967411 creator A5067309414 @default.
• W4379967411 creator A5072983360 @default.
• W4379967411 creator A5078265637 @default.
• W4379967411 creator A5079910160 @default.
• W4379967411 creator A5081833017 @default.
• W4379967411 creator A5083042968 @default.
• W4379967411 creator A5083466961 @default.
• W4379967411 date "2023-06-09" @default.
• W4379967411 modified "2023-10-06" @default.
• W4379967411 title "Urinary Metabolite Profile Predicting the Progression of CKD" @default.
• W4379967411 cites W1828622309 @default.
• W4379967411 cites W1962867466 @default.
• W4379967411 cites W1974739990 @default.
• W4379967411 cites W1991990460 @default.
• W4379967411 cites W2007023866 @default.
• W4379967411 cites W2012258975 @default.
• W4379967411 cites W2045824765 @default.
• W4379967411 cites W2053835433 @default.
• W4379967411 cites W2062222093 @default.
• W4379967411 cites W2084033659 @default.
• W4379967411 cites W2098397904 @default.
• W4379967411 cites W2115944543 @default.
• W4379967411 cites W2155965977 @default.
• W4379967411 cites W2207348770 @default.
• W4379967411 cites W2232990799 @default.
• W4379967411 cites W2292791349 @default.
• W4379967411 cites W2401621255 @default.
• W4379967411 cites W2565573690 @default.
• W4379967411 cites W2607031541 @default.
• W4379967411 cites W2791644192 @default.
• W4379967411 cites W2884738345 @default.
• W4379967411 cites W2920081892 @default.
• W4379967411 cites W3044888080 @default.
• W4379967411 cites W3045422450 @default.
• W4379967411 cites W3047297438 @default.
• W4379967411 cites W3080387067 @default.
• W4379967411 cites W3151400633 @default.
• W4379967411 cites W3157499485 @default.
• W4379967411 cites W3193644797 @default.
• W4379967411 doi "https://doi.org/10.34067/kid.0000000000000158" @default.
• W4379967411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37291728" @default.
• W4379967411 hasPublicationYear "2023" @default.
• W4379967411 type Work @default.
• W4379967411 citedByCount "1" @default.
• W4379967411 crossrefType "journal-article" @default.
• W4379967411 hasAuthorship W4379967411A5002075968 @default.
• W4379967411 hasAuthorship W4379967411A5005659905 @default.
• W4379967411 hasAuthorship W4379967411A5009056330 @default.
• W4379967411 hasAuthorship W4379967411A5015505167 @default.
• W4379967411 hasAuthorship W4379967411A5022646032 @default.
• W4379967411 hasAuthorship W4379967411A5023568077 @default.
• W4379967411 hasAuthorship W4379967411A5023668588 @default.
• W4379967411 hasAuthorship W4379967411A5024161442 @default.
• W4379967411 hasAuthorship W4379967411A5025160124 @default.
• W4379967411 hasAuthorship W4379967411A5028024742 @default.
• W4379967411 hasAuthorship W4379967411A5033449275 @default.
• W4379967411 hasAuthorship W4379967411A5058857350 @default.
• W4379967411 hasAuthorship W4379967411A5061080152 @default.
• W4379967411 hasAuthorship W4379967411A5067309414 @default.
• W4379967411 hasAuthorship W4379967411A5072983360 @default.
• W4379967411 hasAuthorship W4379967411A5078265637 @default.
• W4379967411 hasAuthorship W4379967411A5079910160 @default.
• W4379967411 hasAuthorship W4379967411A5081833017 @default.
• W4379967411 hasAuthorship W4379967411A5083042968 @default.
• W4379967411 hasAuthorship W4379967411A5083466961 @default.
• W4379967411 hasBestOaLocation W43799674111 @default.
• W4379967411 hasConcept C126322002 @default.
• W4379967411 hasConcept C126894567 @default.
• W4379967411 hasConcept C134018914 @default.
• W4379967411 hasConcept C159641895 @default.
• W4379967411 hasConcept C2777248517 @default.
• W4379967411 hasConcept C2777477808 @default.
• W4379967411 hasConcept C2778653478 @default.
• W4379967411 hasConcept C2779561371 @default.
• W4379967411 hasConcept C2780026642 @default.
• W4379967411 hasConcept C2780091579 @default.
• W4379967411 hasConcept C2780306776 @default.
• W4379967411 hasConcept C2781123555 @default.
• W4379967411 hasConcept C2781197716 @default.
• W4379967411 hasConcept C55493867 @default.
• W4379967411 hasConcept C555293320 @default.
• W4379967411 hasConcept C71924100 @default.
• W4379967411 hasConcept C77411442 @default.

• next