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- W4379980241 abstract "To investigate the association between lung function and the different species of bacteria colonizing people with Cystic Fibrosis (pwCF). This is a retrospective study. Data were retrieved from the medical files of patients that visited the CF Center on an outpatient basis over the years 2017–2021. Spirometry was performed 3–4 times yearly, while multiple breath washout test (MBW) was performed at least once a year. In addition, a cough swab or sputum specimen was collected 3–4 times yearly. An adjusted linear mixed model analysis was performed to assess the impact of transient or chronic colonization on the ppFEV1, ppFVC, ppFEF, and LCI over the study period. We evaluated 108 patients with a mean age of 11.8 years (range 0.1 to 29.5) at the first visit. The baseline mean LCI was 10.5 (5.7–23.9), and the ppFEV1 mean 94.3 (34.0–133.0). Furthermore, the most common bacteria identified were transient Non-Multi-Drug Resistant Pseudomonas Aeruginosa (N-MDR-PA) (24.06%), intermittent MSSA (30.72%), and intermittent Stenotrophomonas Maltophilia (10.54%). Mean LCI was significantly higher among patients with chronic MDR-PA (18,50), intermittent MDR-PA (17.11), chronic N-MDR-PA (11.85), intermittent N-MDR-PA (11.3), chronic MRSA (11.87), intermittent Stenotrophomonas Maltophilia (11.24), compared with patients with normal throat flora (9,70), (p < 0.05). Mean ppFEV1 was significantly lower among patients with chronic MDR-PA (54,53), intermittent MDR-PA (61.0), chronic N-MDRPA (74.02), and chronic MRSA (82.0), compared with patients with normal throat flora, (96,39%), (p < 0.05). LCI is a more sensitive tool than FEV1 to assess microbiological status among pwCF. LCI differentiates among different stages of Pseudomonas infection (intermittent, chronic, and MDR-PA vs. N-MDR-PA) among pwCF." @default.
- W4379980241 created "2023-06-10" @default.
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- W4379980241 date "2023-06-01" @default.
- W4379980241 modified "2023-09-27" @default.
- W4379980241 title "P192 Change in lung clearance index with microbiological status in patients with cystic fibrosis" @default.
- W4379980241 doi "https://doi.org/10.1016/s1569-1993(23)00567-2" @default.
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