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- W4379980776 abstract "The vertebrate hypothalamus regulates physiological and behavioral responses to environmental stimuli through the function of evolutionarily-conserved neuronal subpopulations. Our previous work found that mutation of zebrafish lef1 , which encodes a transcriptional mediator of the Wnt signaling pathway, leads to the loss of hypothalamic neurons and behavioral phenotypes that are both associated with stress-related human mood disorders However, the specific Lef1 target genes that link neurogenesis to behavior remain unknown. One candidate is otpb , which encodes a transcription factor with known roles in hypothalamic development. Here we show that otpb expression in the posterior hypothalamus is Lef1-dependent, and that like lef1 , its function is required for the generation of crhbp + neurons in this region. Transgenic reporter analysis of a crhbp conserved noncoding element suggests that otpb participates in a transcriptional regulatory network with other Lef1 targets. Finally, consistent with a role for crhbp in inhibiting the stress response, zebrafish otpb mutants exhibit decreased exploration in a novel tank diving assay. Together our findings suggest a potential evolutionarily-conserved mechanism for the regulation of innate stress response behaviors through Lef1-mediated hypothalamic neurogenesis." @default.
- W4379980776 created "2023-06-10" @default.
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- W4379980776 date "2023-06-09" @default.
- W4379980776 modified "2023-09-27" @default.
- W4379980776 title "<i>otpb</i>functions in a Lef1-dependent transcriptional network required for expression of the stress response inhibitor<i>crhbp</i>in the zebrafish hypothalamus" @default.
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- W4379980776 doi "https://doi.org/10.1101/2023.06.07.544119" @default.
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