Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379981972> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4379981972 abstract "Abstract The key ingredient in Nigella sativa , thymoquinone (TQ), has several advantageous qualities, particularly antioxidant and anti-inflammatory ones. Recent research studies have shown the beneficial effects of thymoquinone, and this study aimed to look into how it affected vitamin D metabolism in populations with insulin resistance. Male Wistar-Albino rats were employed in the study as the subject matter for this reason. TQ was administered as a therapy, and prophylaxis and treatment with metformin were set up for the groups in which insulin resistance had been developed. The gene groups implicated in vitamin D metabolism underwent RT-PCR gene expression analysis and western blot protein analysis. The analysis's findings show that the application of TQ reduced HOMA-IR values, a sign of insulin resistance. It was found that the expression of the VDR gene may be responsible for the effect of TQ administration for the treatment of insulin resistance on vitamin D metabolism in liver tissue. The evaluation of TQ's effects on the gene expression of the genes involved in vitamin D metabolism in liver tissue and their translation into a protein produced significant findings. It has been demonstrated that using TQ for therapeutic and preventive reasons is advantageous for regressing insulin resistance metrics. Also found to be impacted was serum vitamin D level, which was found to be directly related to the expression of several genes involved in vitamin D metabolism in the liver, although some of these genes were found to be relatively ineffective in the present study." @default.
- W4379981972 created "2023-06-10" @default.
- W4379981972 creator A5000378150 @default.
- W4379981972 creator A5092122525 @default.
- W4379981972 date "2023-06-09" @default.
- W4379981972 modified "2023-10-02" @default.
- W4379981972 title "The Effect of Tymoquinone on Vitamin D Metabolism in Glucocorticoid-Induced Insulin Resistance" @default.
- W4379981972 cites W2144702175 @default.
- W4379981972 cites W2600030322 @default.
- W4379981972 cites W2736457177 @default.
- W4379981972 cites W2754170368 @default.
- W4379981972 cites W2892144926 @default.
- W4379981972 cites W2942781754 @default.
- W4379981972 cites W2973122616 @default.
- W4379981972 cites W3084021424 @default.
- W4379981972 cites W3136508952 @default.
- W4379981972 cites W3173987594 @default.
- W4379981972 doi "https://doi.org/10.21203/rs.3.rs-3024468/v1" @default.
- W4379981972 hasPublicationYear "2023" @default.
- W4379981972 type Work @default.
- W4379981972 citedByCount "0" @default.
- W4379981972 crossrefType "posted-content" @default.
- W4379981972 hasAuthorship W4379981972A5000378150 @default.
- W4379981972 hasAuthorship W4379981972A5092122525 @default.
- W4379981972 hasBestOaLocation W43799819721 @default.
- W4379981972 hasConcept C104317684 @default.
- W4379981972 hasConcept C126322002 @default.
- W4379981972 hasConcept C134018914 @default.
- W4379981972 hasConcept C150194340 @default.
- W4379981972 hasConcept C17093226 @default.
- W4379981972 hasConcept C2776782570 @default.
- W4379981972 hasConcept C2776940978 @default.
- W4379981972 hasConcept C2777391703 @default.
- W4379981972 hasConcept C2777551382 @default.
- W4379981972 hasConcept C2778004101 @default.
- W4379981972 hasConcept C2779034068 @default.
- W4379981972 hasConcept C2779306644 @default.
- W4379981972 hasConcept C2993714443 @default.
- W4379981972 hasConcept C4733338 @default.
- W4379981972 hasConcept C55493867 @default.
- W4379981972 hasConcept C556039675 @default.
- W4379981972 hasConcept C62231903 @default.
- W4379981972 hasConcept C71924100 @default.
- W4379981972 hasConcept C86803240 @default.
- W4379981972 hasConcept C98274493 @default.
- W4379981972 hasConceptScore W4379981972C104317684 @default.
- W4379981972 hasConceptScore W4379981972C126322002 @default.
- W4379981972 hasConceptScore W4379981972C134018914 @default.
- W4379981972 hasConceptScore W4379981972C150194340 @default.
- W4379981972 hasConceptScore W4379981972C17093226 @default.
- W4379981972 hasConceptScore W4379981972C2776782570 @default.
- W4379981972 hasConceptScore W4379981972C2776940978 @default.
- W4379981972 hasConceptScore W4379981972C2777391703 @default.
- W4379981972 hasConceptScore W4379981972C2777551382 @default.
- W4379981972 hasConceptScore W4379981972C2778004101 @default.
- W4379981972 hasConceptScore W4379981972C2779034068 @default.
- W4379981972 hasConceptScore W4379981972C2779306644 @default.
- W4379981972 hasConceptScore W4379981972C2993714443 @default.
- W4379981972 hasConceptScore W4379981972C4733338 @default.
- W4379981972 hasConceptScore W4379981972C55493867 @default.
- W4379981972 hasConceptScore W4379981972C556039675 @default.
- W4379981972 hasConceptScore W4379981972C62231903 @default.
- W4379981972 hasConceptScore W4379981972C71924100 @default.
- W4379981972 hasConceptScore W4379981972C86803240 @default.
- W4379981972 hasConceptScore W4379981972C98274493 @default.
- W4379981972 hasLocation W43799819721 @default.
- W4379981972 hasOpenAccess W4379981972 @default.
- W4379981972 hasPrimaryLocation W43799819721 @default.
- W4379981972 hasRelatedWork W138803513 @default.
- W4379981972 hasRelatedWork W1986132654 @default.
- W4379981972 hasRelatedWork W1988439151 @default.
- W4379981972 hasRelatedWork W2026316039 @default.
- W4379981972 hasRelatedWork W2096423991 @default.
- W4379981972 hasRelatedWork W2120688902 @default.
- W4379981972 hasRelatedWork W2124038922 @default.
- W4379981972 hasRelatedWork W2375944679 @default.
- W4379981972 hasRelatedWork W2381618357 @default.
- W4379981972 hasRelatedWork W3028839963 @default.
- W4379981972 isParatext "false" @default.
- W4379981972 isRetracted "false" @default.
- W4379981972 workType "article" @default.