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• W4379983514 abstract "<h3>Background</h3> Chemoradiotherapy treatment (CRT) for head and neck cancer (HNC) is associated with toxicities such as mucositis and dysphagia. Oropharyngeal microbiota may play a role in these toxicities, however, the causative link and clinical relevance remain unclear. Aims: 1) determine if dysbiosis is present in HNC and the impact of CRT on the course of the dysbiosis during and after treatment; 2) investigate whether mucositis and associated dysbiosis after CRT are risk factors for long-term dysphagia. <h3>Methods</h3> Prospective longitudinal observational study to analyse the diversity and composition of saliva microbiome samples collected from 47 HNC patients (age 64, SD±12.2) undergoing CRT and 20 non-HNC controls (age 68, SD±10.5) using metagenomics sequencing. HNC samples were collected before CRT, immediately and 12 months after completion of CRT. Mucositis was assessed using the WHO Oral Mucositis Grading Scale. Dysphagia was assessed using Sydney Swallow Questionnaire (SSQ). <h3>Results</h3> The salivary microbiome in HNC pre-treatment was compositionally different and exhibited decreased diversity compared to controls. During treatment, α-diversity decreased significantly, and β-diversity showed a significant compositional change from pre-treatment and healthy controls (p<0.05). Twelve months post-treatment, the microbiome showed a significant recovery in diversity and a shift in composition (IDDF2023-ABS-0249 Figure 1. Alpha diversity comparison and beta diversity analysis between healthy controls and HNC patients at 3 microbiome collection points before during and 12 months post CRT). Severe mucositis during treatment was associated with a higher prevalence of long-term dysphagia (IDDF2023-ABS-0249 Figure 2 (A) Comparison of SSQ score at 12 months between HNC patients with mild moderate and severe mucositis during treatment). Microbiome analysis revealed no difference in α-diversity between severe and mild-moderate mucositis groups before treatment but marked differences immediately after CRT. At twelve months, the severe group microbiome diversity remained low, while the mild-moderate group recovered significantly (IDDF2023-ABS-0249 Figure 2 (B) Longitudinal microbiome alpha diversity based on mucos). β-diversity showed a more profound microbiome shift in the severe group at 12 months compared to the mild-moderate group. Dysphagic patients at 12 months had lower diversity (IDDF2023-ABS-0249 Figure 2C) than non-dysphagic patients, while the composition shift was not significant. <h3>Conclusions</h3> Results demonstrate the presence of dysbiosis in HNC and the impact of CRT on the oropharyngeal microbiome. Results also suggest that severe mucositis and associated dysbiosis after CRT may contribute to long-term dysphagia. These findings may help to develop strategies for microbiome-based interventions to improve treatment outcomes and reduce complications." @default.
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• W4379983514 date "2023-06-01" @default.
• W4379983514 modified "2023-09-22" @default.
• W4379983514 title "IDDF2023-ABS-0249 Implications of oro-pharyngeal dysbiosis in head and neck cancer: oral microbiome and chemoradiation-related complications" @default.
• W4379983514 doi "https://doi.org/10.1136/gutjnl-2023-iddf.101" @default.
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