FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379983903> ?p ?o ?g. }

• W4379983903 endingPage "1088" @default.
• W4379983903 startingPage "1088" @default.
• W4379983903 abstract "Abstract Purpose. Resistance to radiation, both intrinsic and acquired, remains a significant clinical challenge. It is therefore import to identify the underlying molecular and cellular features involved in this resistance. Materials and Methods. We generated genetically-matched counterparts of various degrees of radiation sensitivity in non-small cell lung carcinoma (NSCLC) tumor models to define characteristics of acquired resistance through repeated exposures to conventional X-ray radiation. Results. As assessed by cell viability and clonogenic assays murine Lewis lung carcinoma (LLC) and human A549 cell lines acquired an approximate 1.5 - 2-fold increase in radiation resistance (RR) as compared to its parental counterpart. Morphologically, we found that A549-RR exhibited a greater nucleus-to-cytosol (N/C) ratio as compared to its respective counterpart. Since the N/C ratio has been linked to the differentiation state, we next investigated the epithelial-to-mesenchymal transition (EMT) phenotype and cellular plasticity. We found that A549 have a greater radiation-induced plasticity, as measured by E-cadherin, vimentin and double positive (DP) modulation, as compared to LLC. Additionally, migration was suppressed in A549-RR, as compared to A549. Subsequently, we confirmed that the LLC-RR and A549-RR are also more resistant to radiotherapy than their isogenic-matched counterpart in vivo. Remarkably, we found that the acquired radiation resistance also induced resistance to first-line chemotherapeutic cisplatin, but not carboplatin or oxaliplatin. This cross-resistance was attributed to induced elevated thiol levels. Decreasing the amount of thiols with buthionine sulfoximine (BSO), a gamma-glutamylcysteine synthetase inhibitor, sensitized the resistant cells to cisplatin, to levels similar as parental cells. Conclusions. By generating genetically-matched radiation resistant NSCLC tumor models we were able to identify and overcome cisplatin cross-resistance. This is an important finding arguing for multi-modality treatment regimens with the potential of improving clinical outcomes in the future. Citation Format: Samir V. Jenkins, Shruti Shah, Azemat Jamshidi-Parsian, Amir Mortazavi, Gunnar Boysen, Kieng B. Vang, Robert J. Griffin, Narasimhan Rajaram, Ruud P. Dings. Acquired radiation resistance induces thiol-dependent cisplatin cross-resistance [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1088." @default.
• W4379983903 created "2023-06-10" @default.
• W4379983903 creator A5007185710 @default.
• W4379983903 creator A5034278848 @default.
• W4379983903 creator A5035086429 @default.
• W4379983903 creator A5037331031 @default.
• W4379983903 creator A5050152542 @default.
• W4379983903 creator A5060298788 @default.
• W4379983903 creator A5063122794 @default.
• W4379983903 creator A5066789164 @default.
• W4379983903 creator A5078568167 @default.
• W4379983903 date "2023-04-04" @default.
• W4379983903 modified "2023-09-23" @default.
• W4379983903 title "Abstract 1088: Acquired radiation resistance induces thiol-dependent cisplatin cross-resistance" @default.
• W4379983903 doi "https://doi.org/10.1158/1538-7445.am2023-1088" @default.
• W4379983903 hasPublicationYear "2023" @default.
• W4379983903 type Work @default.
• W4379983903 citedByCount "0" @default.
• W4379983903 crossrefType "journal-article" @default.
• W4379983903 hasAuthorship W4379983903A5007185710 @default.
• W4379983903 hasAuthorship W4379983903A5034278848 @default.
• W4379983903 hasAuthorship W4379983903A5035086429 @default.
• W4379983903 hasAuthorship W4379983903A5037331031 @default.
• W4379983903 hasAuthorship W4379983903A5050152542 @default.
• W4379983903 hasAuthorship W4379983903A5060298788 @default.
• W4379983903 hasAuthorship W4379983903A5063122794 @default.
• W4379983903 hasAuthorship W4379983903A5066789164 @default.
• W4379983903 hasAuthorship W4379983903A5078568167 @default.
• W4379983903 hasConcept C117262875 @default.
• W4379983903 hasConcept C126322002 @default.
• W4379983903 hasConcept C147447768 @default.
• W4379983903 hasConcept C153911025 @default.
• W4379983903 hasConcept C181199279 @default.
• W4379983903 hasConcept C185592680 @default.
• W4379983903 hasConcept C203014093 @default.
• W4379983903 hasConcept C204232928 @default.
• W4379983903 hasConcept C206684579 @default.
• W4379983903 hasConcept C207001950 @default.
• W4379983903 hasConcept C2776694085 @default.
• W4379983903 hasConcept C2777476445 @default.
• W4379983903 hasConcept C2778080818 @default.
• W4379983903 hasConcept C2778239845 @default.
• W4379983903 hasConcept C502942594 @default.
• W4379983903 hasConcept C509974204 @default.
• W4379983903 hasConcept C538909803 @default.
• W4379983903 hasConcept C54355233 @default.
• W4379983903 hasConcept C55493867 @default.
• W4379983903 hasConcept C71924100 @default.
• W4379983903 hasConcept C81729549 @default.
• W4379983903 hasConcept C81885089 @default.
• W4379983903 hasConcept C86803240 @default.
• W4379983903 hasConceptScore W4379983903C117262875 @default.
• W4379983903 hasConceptScore W4379983903C126322002 @default.
• W4379983903 hasConceptScore W4379983903C147447768 @default.
• W4379983903 hasConceptScore W4379983903C153911025 @default.
• W4379983903 hasConceptScore W4379983903C181199279 @default.
• W4379983903 hasConceptScore W4379983903C185592680 @default.
• W4379983903 hasConceptScore W4379983903C203014093 @default.
• W4379983903 hasConceptScore W4379983903C204232928 @default.
• W4379983903 hasConceptScore W4379983903C206684579 @default.
• W4379983903 hasConceptScore W4379983903C207001950 @default.
• W4379983903 hasConceptScore W4379983903C2776694085 @default.
• W4379983903 hasConceptScore W4379983903C2777476445 @default.
• W4379983903 hasConceptScore W4379983903C2778080818 @default.
• W4379983903 hasConceptScore W4379983903C2778239845 @default.
• W4379983903 hasConceptScore W4379983903C502942594 @default.
• W4379983903 hasConceptScore W4379983903C509974204 @default.
• W4379983903 hasConceptScore W4379983903C538909803 @default.
• W4379983903 hasConceptScore W4379983903C54355233 @default.
• W4379983903 hasConceptScore W4379983903C55493867 @default.
• W4379983903 hasConceptScore W4379983903C71924100 @default.
• W4379983903 hasConceptScore W4379983903C81729549 @default.
• W4379983903 hasConceptScore W4379983903C81885089 @default.
• W4379983903 hasConceptScore W4379983903C86803240 @default.
• W4379983903 hasIssue "7_Supplement" @default.
• W4379983903 hasLocation W43799839031 @default.
• W4379983903 hasOpenAccess W4379983903 @default.
• W4379983903 hasPrimaryLocation W43799839031 @default.
• W4379983903 hasRelatedWork W2010133479 @default.
• W4379983903 hasRelatedWork W2042329227 @default.
• W4379983903 hasRelatedWork W2070775673 @default.
• W4379983903 hasRelatedWork W2079161724 @default.
• W4379983903 hasRelatedWork W2085871240 @default.
• W4379983903 hasRelatedWork W2328719907 @default.
• W4379983903 hasRelatedWork W2411145041 @default.
• W4379983903 hasRelatedWork W2757419532 @default.
• W4379983903 hasRelatedWork W4379983903 @default.
• W4379983903 hasRelatedWork W1648648517 @default.
• W4379983903 hasVolume "83" @default.
• W4379983903 isParatext "false" @default.
• W4379983903 isRetracted "false" @default.
• W4379983903 workType "article" @default.