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- W4379984612 abstract "Abstract Very few researchers have focused on the biological efficacy of Limonium plants. In this concern, no investigations were commenced to delve into the in vitro and ex vivo biological actions of Limonium pruinosum in Egypt. Therefore, this work aims to assess for the first time the antimicrobial, antioxidant, and antitumor activities of Limonium pruinosum extract in addition to studying its ability to suppress the transcription of cell cycle–stimulating genes. L. pruinosum ethyl acetate extract exhibits considerable antibacterial and antibiofilm activity versus E. coli ATCC 25922 and Staphylococcus aureus ATCC 25923. Results revealed that L. pruinosum exerts antioxidant effectiveness concerning DPPH, nitric oxide (NO), and hydroxyl radical (OH) scavenging ability with an IC 50 (35.88 ± 2.2, 51.31 ± 1.06, and 65.87 ± 1.19 μg/mL) respectively. The results proved the effectiveness of L. pruinosum in closing wounds in gastric epithelial cells (GES-1) by (79.9343 ± 1.98%) compared with control (68.3637 ± 2.32%) in 48 h. Additionally, L. pruinosum had anticancer activity contrary to breast cancer MCF-7 and liver cancer HepG-2 cell lines with IC 50 values of 96.73 ± 2.18 and 81.81 ± 0.99 μg/mL, respectively, while it had no cytotoxic activity against (Wi-38) normal cells. Also, L. pruinosum extract provoked considerable early- and late-apoptotic cell populations and was effective in inducing cell death of MCF-7. Our findings evoked that L. pruinosum has promising antibacterial, antioxidant, and wound healing activities and a good breast tumor suppressor arresting the cell cycle-stimulating genes, which may be an auspicious approach for the treatment of breast cancer." @default.
- W4379984612 created "2023-06-10" @default.
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- W4379984612 date "2023-06-09" @default.
- W4379984612 modified "2023-10-14" @default.
- W4379984612 title "Biological activities and ecological aspects of Limonium pruinosum (L.) collected from Wadi Hof Eastern Desert, Egypt, as a promising attempt for potential medical applications" @default.
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- W4379984612 doi "https://doi.org/10.1007/s13399-023-04385-5" @default.
- W4379984612 hasPublicationYear "2023" @default.
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