FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380028158> ?p ?o ?g. }

• W4380028158 abstract "<sec> <title>BACKGROUND</title> Drug-induced suicide (DIS) is a severe adverse drug reaction (ADR). Although clinical trials have provided evidence on DIS, limited investigations have been performed on rare ADRs, such as suicide. </sec> <sec> <title>OBJECTIVE</title> We aimed to systematically review case reports on DIS to provide evidence-based drug information. </sec> <sec> <title>METHODS</title> We searched PubMed to obtain case reports regarding DIS published until July 2021. Cases due to drugs that are no longer used or are nonapproved, substance use, and suicidal intentions were excluded. The quality of each case report was assessed using the CARE checklist. We extracted data regarding demographics, medication history, suicide symptoms, and symptom improvement and evaluated the causality of DIS using the Naranjo score. Furthermore, to identify the potential suicidal risk of the unknown drugs, we compared the results of the causality assessment with those of the approved drug labels. </sec> <sec> <title>RESULTS</title> In 83 articles, we identified 152 cases involving 61 drugs. Antidepressants were reported as the most frequent causative drugs of DIS followed by immunostimulants. The causality assessment revealed 61 cases having possible, 89 cases having probable, and 2 cases having definite relationships with DIS. For approximately 85% of suspected drugs, the risk of suicidal ADRs was indicated on the approved label; however, the approved labels for nine drugs, including lumacaftor/ivacaftor, doxycycline, clozapine, dextromethorphan, adalimumab, infliximab, piroxicam, paclitaxel, and formoterol, did not provide information about these risks. </sec> <sec> <title>CONCLUSIONS</title> We found several case reports involving drugs without suicide risk information on the drug label. Our findings might provide valuable insights into drugs that may cause suicidal ADRs. </sec>" @default.
• W4380028158 created "2023-06-10" @default.
• W4380028158 creator A5015598872 @default.
• W4380028158 creator A5041927706 @default.
• W4380028158 creator A5060860858 @default.
• W4380028158 creator A5077127136 @default.
• W4380028158 creator A5081599562 @default.
• W4380028158 date "2023-06-08" @default.
• W4380028158 modified "2023-09-24" @default.
• W4380028158 title "Drug-induced suicide: a systematic review of case reports and comparison of the safety information with the approved drug label (Preprint)" @default.
• W4380028158 doi "https://doi.org/10.2196/preprints.49755" @default.
• W4380028158 hasPublicationYear "2023" @default.
• W4380028158 type Work @default.
• W4380028158 citedByCount "0" @default.
• W4380028158 crossrefType "posted-content" @default.
• W4380028158 hasAuthorship W4380028158A5015598872 @default.
• W4380028158 hasAuthorship W4380028158A5041927706 @default.
• W4380028158 hasAuthorship W4380028158A5060860858 @default.
• W4380028158 hasAuthorship W4380028158A5077127136 @default.
• W4380028158 hasAuthorship W4380028158A5081599562 @default.
• W4380028158 hasConcept C118552586 @default.
• W4380028158 hasConcept C126322002 @default.
• W4380028158 hasConcept C190385971 @default.
• W4380028158 hasConcept C194828623 @default.
• W4380028158 hasConcept C197934379 @default.
• W4380028158 hasConcept C2776412080 @default.
• W4380028158 hasConcept C2776641880 @default.
• W4380028158 hasConcept C2779488553 @default.
• W4380028158 hasConcept C2780035454 @default.
• W4380028158 hasConcept C2780634440 @default.
• W4380028158 hasConcept C3017944768 @default.
• W4380028158 hasConcept C71924100 @default.
• W4380028158 hasConceptScore W4380028158C118552586 @default.
• W4380028158 hasConceptScore W4380028158C126322002 @default.
• W4380028158 hasConceptScore W4380028158C190385971 @default.
• W4380028158 hasConceptScore W4380028158C194828623 @default.
• W4380028158 hasConceptScore W4380028158C197934379 @default.
• W4380028158 hasConceptScore W4380028158C2776412080 @default.
• W4380028158 hasConceptScore W4380028158C2776641880 @default.
• W4380028158 hasConceptScore W4380028158C2779488553 @default.
• W4380028158 hasConceptScore W4380028158C2780035454 @default.
• W4380028158 hasConceptScore W4380028158C2780634440 @default.
• W4380028158 hasConceptScore W4380028158C3017944768 @default.
• W4380028158 hasConceptScore W4380028158C71924100 @default.
• W4380028158 hasLocation W43800281581 @default.
• W4380028158 hasOpenAccess W4380028158 @default.
• W4380028158 hasPrimaryLocation W43800281581 @default.
• W4380028158 hasRelatedWork W1965353955 @default.
• W4380028158 hasRelatedWork W1979295630 @default.
• W4380028158 hasRelatedWork W2048124537 @default.
• W4380028158 hasRelatedWork W2059773035 @default.
• W4380028158 hasRelatedWork W2132358484 @default.
• W4380028158 hasRelatedWork W2151384000 @default.
• W4380028158 hasRelatedWork W2276234421 @default.
• W4380028158 hasRelatedWork W2412173674 @default.
• W4380028158 hasRelatedWork W3043890169 @default.
• W4380028158 hasRelatedWork W4212785353 @default.
• W4380028158 isParatext "false" @default.
• W4380028158 isRetracted "false" @default.
• W4380028158 workType "article" @default.